综述 Review

脱氧雪腐镰刀菌烯醇的代谢特征

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  • 中国农业科学院农业质量标准与检测技术研究所, 农业部农产品质量安全重点实验室, 北京 100081
张志岐(1983-),女,山东德州人,博士后,主要从事饲料安全与质量控制方向的研究。E-mail:zzq19830619@163.com

收稿日期: 2015-09-15

  网络出版日期: 2016-03-14

基金资助

"十二五"农村领域国家科技计划(2011BAD26B0450);公益性行业(农业)科研专项经费(20120388-01)

Metabolic Characteristics of Deoxynivalenol

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  • Institute of Quality Standards and Testing Technology for Agricultural Products, Chniese Academy of Agricultural Science, Key Laboratory of Agrifood Safety and Quality, Ministry of Agriculture, Beijing 100081, China

Received date: 2015-09-15

  Online published: 2016-03-14

摘要

脱氧雪腐镰刀菌烯醇(DON)对以谷物为基础的食物和饲料的污染是一个全球性问题,严重危害了人和动物的健康。DON在人和动物体内的代谢特征是开展DON暴露评估、毒性作用机制和干预技术等研究的基础。近年来有关DON的吸收、分布、代谢和排泄等毒物动力学的研究引起了国内外广泛关注。本文将DON代谢特征的最新进展进行了全面的综述。

本文引用格式

张志岐, 王瑞国, 张维, 王培龙, 苏晓鸥 . 脱氧雪腐镰刀菌烯醇的代谢特征[J]. 动物营养学报, 2016 , 28(3) : 641 -651 . DOI: 10.3969/j.issn.1006-267x.2016.03.002

Abstract

Deoxynivalenol (DON) contamination of food and feed based on grain is a global problem, and it causes serious damage to human and animal health. Metabolic characteristics of DON in humans and animals are the foundation of the DON exposure assessment, toxicology mechanism and intervention technique research. In recent years, the absorption, distribution, metabolism and excretion of DON have caused wide public concern. This paper reviewed the latest research progress of the metabolic characteristics of DON.

参考文献

[1] BENNETT J W,KLICH M.Mycotoxins[J].Clinical Microbiology Reviews,2003,16(3):497-516.  

[2] WU Q H,LOHREY L,CRAMER B,et al.Impact of physicochemical parameters on the decomposition of deoxynivalenol during extrusion cooking of wheat grits[J].Journal of Agricultural and Food Chemistry,2011,59(23):12480-12485.  

[3] MONTES R,SEGARRA R,CASTILLO M Á.Trichothecenes in breakfast cereals from the Spanish retail market[J].Journal of Food Composition and Analysis,2012,27(1):38-44.  

[4] JAJI? I,JURI? V,ABRAMOVI? B.First survey of deoxynivalenol occurrence in crops in Serbia[J].Food Control,2008,19(6):545-550.  

[5] MALACHOVA A,DZUMAN Z,VEPRIKOVA Z,et al.Deoxynivalenol,deoxynivalenol-3-glucoside,and enniatins:the major mycotoxins found in cereal-based products on the czech market[J].Journal of Agricultural and Food Chemistry,2011,59(24):12990-12997.

[6] TRAN S T,SMITH T K,GIRGIS G N.A survey of free and conjugated deoxynivalenol in the 2008 corn crop in Ontario,Canada[J].Journal of the Science of Food and Agriculture,2012,92(1):37-41.  

[7] TRAN S T,SMITH T K.A survey of free and conjugated deoxynivalenol in the 2009,2010 and 2011 cereal crops in Australia[J].Animal Production Science,2013,53(5):407-412.  

[8] CUI L,SELVARAJ J N,XING F G,et al.A minor survey of deoxynivalenol in Fusarium infected wheat from Yangtze-Huaihe river basin region in China[J].Food Control,2013,30(2):469-473.  

[9] BENSASSI F,ZAIED C,ABID S,et al.Occurrence of deoxynivalenol in durum wheat in Tunisia[J].Food Control, 2010,21(3):281-285.  

[10] SHEPHARD G S,WESTHUIZEN L V D,KATERERE D R,et al.Preliminary exposure assessment of deoxynivalenol and patulin in South Africa[J].Mycotoxin Research,2010,26(3):181-185.

[11] LOMBAERT G A,PELLAERS P,ROSCOE V,et al.Mycotoxins in infant cereal foods from the Canadian retail market[J].Food Additives & Contaminants,2003,20(5):494-504.  

[12] BRYDEN W L.Mycotoxins in the food chain:human health implications[J].Asia Pacific Journal of Clinical Nutrition,2007,16:95-101.

[13] CHAYTOR A C,HANSEN J A,VAN HEUGTEN E,et al.Occurrence and decontamination of mycotoxins in swine feed[J].Asian-Australasian Journal of Animal Sciences,2011,24(5): 723-738.  

[14] WU Q H,DOHNAL V,HUANG L L,et al.Metabolic pathways of trichothecenes[J].Drug Metabolism Reviews,2010,42(2):250-267.  

[15] MEKY F A,TURNER P C,ASHCROFT A E,et al.Development of a urinary biomarker of human exposure to deoxynivalenol[J].Food and Chemical Toxicology,2003,41(2):265-273.  

[16] WARTH B,SILYOK M,FRUHMANN P,et al.Development and validation of a rapid multi-biomarker liquid chromatography/tandem mass spectrometry method to assess human exposure to mycotoxins[J].Rapid Communications in Mass Spectrometry,2012,26(13):1533-1540.  

[17] SCHOTHORST R C,VAN EGMOND H P.Report from SCOOP task 3.2.10 "collection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU member states"-Subtask: trichothecenes[J].Toxicology Letters,2004,153(1):133-143.  

[18] MONBALIU S,VAN POUCKE C,DETAVEMIER C L,et al.Occurrence of mycotoxins in feed as analyzed by a multi-mycotoxin LC-MS/MS method[J].Journal of Agricultural and Food Chemistry,2010,58(1):66-71.  

[19] SCHENZEL J,HUNGERBVHLER K,BUCHELI T D.Mycotoxins in the environment:Ⅱ.Occurrence and origin in swiss river waters[J].Environmental Science & Technology,2012,46(24):13076-13084.  

[20] BRYDEN W L.Mycotoxin contamination of the feed supply chain: implications for animal productivity and feed security[J].Animal Feed Science and Technology,2012,173(1/2):134-158.

[21] CUNDLIFFE E,CANNON M,DAVIES J.Mechanism of inhibition of eukaryotic protein synthesis by trichothecene fungal toxins[J].Proceedings of the National Academy of Sciences of the United States of America,1974,71(1):30-34.  

[22] BIN-UMER M A,MCLAUGHLIN J E,BASU D,et al.Trichothecene mycotoxins inhibit mitochondrial translation-implication for the mechanism of toxicity[J].Toxins,2011,3(12):1484-1501.  

[23] PESTKA J J,ZHOU H R,MOON Y,et al.Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes:unraveling a paradox[J].Toxicology Letters,2004,153(1):61-73.  

[24] PESTKA J J,ISLAM Z,AMUZIE C J.Immunochemical assessment of deoxynivalenol tissue distribution following oral exposure in the mouse[J].Toxicology Letters,2008,178(2):83-87.  

[25] PESTKA J J.Deoxynivalenol:mechanisms of action,human exposure,and toxicological relevance[J].Archives of Toxicology,2010,84(9):663-679.  

[26] PESTKA J J.Deoxynivalenol-induced proinflammatory gene expression: mechanisms and pathological sequelae[J].Toxins,2010,2(6):1300-1317.  

[27] SUNDSTØL ERIKSEN G,PETTERSSON H,LUNDH T.Comparative cytotoxicity of deoxynivalenol,nivalenol,their acetylated derivatives and de-epoxy metabolites[J].Food and Chemical Toxicology,2004,42(4):619-624.  

[28] DÄNICKE S,GOYARTS T,DÖLL S,et al.Effects of the Fusarium toxin deoxynivalenol on tissue protein synthesis in pigs[J].Toxicology Letters,2006,165(3):297-311.  

[29] BARNETT A M,ROY N C,McNABB W C,et al.The interactions between endogenous bacteria, dietary components and the mucus layer of the large bowel[J].Food & Function,2012,3(7):690-699.  

[30] SMITH H W.Observations on the flora of the alimentary tract of animals and factors affecting its composition[J].Journal of Pathology and Bacteriology,1965,89(1):95-122.  

[31] PRELUSKY D B,VEIRA D M,TREMHOLM H L.Plasma pharmacokinetics of the mycotoxin deoxynivalenol following oral and intravenous administration to sheep[J].Journal of Environmental Science and Health,Part B:Pesticides,Food Contaminants and Agricultural Wastes,1985,20(6):603-624.  

[32] OSSELAERE A,DEVREESE M,GOOSSENS J,et al.Toxicokinetic study and absolute oral bioavailability of deoxynivalenol,T-2 toxin and zearalenone in broiler chickens[J].Food and Chemical Toxicology,2013,51:350-355.

[33] ROHWEDER D,KERSTEN S,VALENTA H,et al.Bioavailability of the Fusarium toxin deoxynivalenol (DON) from wheat straw and chaff in pigs[J].Archives of Animal Nutrition,2013,67(1):37-47.  

[34] PRELUSKY D B,TRENHOLM H L,LAWRENCE G A,et al.Nontransmission of deoxynivalenol (vomitoxin) to milk following oral administration to dairy cows[J].Journal of Environmental Science and Health,PartB:Pesticides,Food Contaminants and Agricultural Wastes,1984,19(7):593-609.  

[35] FREY J C,PELL A N,BERTHIAUME R,et al.Comparative studies of microbial populations in the rumen,duodenum,ileum and faeces of lactating dairy cows[J].Journal of Applied Microbiology,2010,108(6):1982-1993.

[36] FARNER D S.The hydrogen ion concentration in avian digestive tracts[J].Poultry Science,1942,21:445-450.

[37] AO T,CANTOR A H,PESCATORE A J,et al.In vitro evaluation of feed-grade enzyme activity at pH levels simulating various parts of the avian digestive tract[J].Animal Feed Science and Technology,2008,140(3/4):462-468.

[38] ROTTER B A,PRELUSKY D B,PESTKA J J.Toxicology of deoxynivalenol (vomitoxin)[J].Journal of Toxicology and Environmental Health,1996,48(1):1-34.  

[39] ERIKSEN G S,PETTERSSON H,JOHNSEN K,et al.Transformation of trichothecenes in ileal digesta and faeces from pigs[J].Archives of Animal Nutrition,2002, 56(4):263-274.

[40] DÄNICKE S,VALENTA H,DÖLL S.On the toxicokinetics and the metabolism of deoxynivalenol (DON) in the pig[J].Archives of Animal Nutrition,2004,58(2):169-180.  

[41] PRELUSKY D B,HARTIN K E,TRENHOLM H L,et al.Pharmacokinetic fate of 14C-labeled deoxynivalenol in swine[J].Fundamental and Applied Toxicology,1988,10(2):276-286.  

[42] AWAD W A,ASCHENBACH J R,SETYABUDI F M,et al.In vitro effects of deoxynivalenol on small intestinal D-glucose uptake and absorption of deoxynivalenol across the isolated jejunal epithelium of laying hens[J].Poultry Science,2007,86(1):15-20.  

[43] SERGENT T,PARYS M,GARSOU S,et al.Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellular metabolism at realistic intestinal concentrations[J].Toxicology Letters,2006,164(2):167-176.

[44] MARESCA M,FANTINI J.Some food-associated mycotoxins as potential risk factors in humans predisposed to chronic intestinal inflammatory diseases[J].Toxicon,2010,56(3):282-294.  

[45] SCHULZKE J D,GVENZEL D,JOHN L J,et al.Perspectives on tight junction research[J].Annals of the New York Academy of Sciences,2012,1257:1-19.

[46] TAKAHASHI A,KONDOH M,SUZUKI H,et al.Pathological changes in tight junctions and potential applications into therapies[J].Drug Discovery Today,2012,17(13/14):727-732.

[47] GOYARTS T,DÄNICKE S.Bioavailability of the Fusarium toxin deoxynivalenol (DON) from naturally contaminated wheat for the pig[J].Toxicology Letters,2006,163(3):171-182.  

[48] DIESING A K,NOSSOL C,DANICKE S,et al.Vulnerability of polarised intestinal porcine epithelial cells to mycotoxin deoxynivalenol depends on the route of application[J].PLoS One,2011,6(2):e17472.

[49] PINTON P,BRAICU C,NOUGAYREDE J P,et al.Deoxynivalenol impairs porcine intestinal barrier function and decreases the protein expression of claudin-4 through a mitogen-activated protein kinase-dependent mechanism[J].Journal of Nutrition,2010,140(11):1956-1962.  

[50] DIESING A K,NOSSOL C,PANTHER P,et al.Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2[J].Toxicology Letters,2011,200(1/2):8-18.

[51] YNUNS A W,BLAJET-KOSICKA A,KOSICKI R,et al.Deoxynivalenol as a contaminant of broiler feed:intestinal development, absorptive functionality, and metabolism of the mycotoxin[J].Poultry Science,2012,91(4):852-861.  

[52] OSSELAERE A,DEVEREESE M,WATTEYN A,et al.Efficacy and safety testing of mycotoxin-detoxifying agents in broilers following the European Food Safety Authority guidelines[J].Poultry Science,2012,91(8):2046-2054.  

[53] PRELUSKY D B,HARTIN K E,TRENHOLM H L.Distribution of deoxynivalenol in cerebral spinal fluid following administration to swine and sheep[J].Journal of Environmental Science and Health,Part B:Pesticides,Food Contaminants, and Agricultural Wastes,1990,25(3):395-413.  

[54] VIDEMANN B,TEP J,CAVERT S,et al.Epithelial transport of deoxynivalenol:involvement of human P-glycoprotein (ABCB1) and multidrug resistance-associated protein 2 (ABCC2)[J]. Food and Chemical Toxicology,2007,45(10):1938-1947.  

[55] DÄNICKE S,BREZINA U.Kinetics and metabolism of the Fusarium toxin deoxynivalenol in farm animals: consequences for diagnosis of exposure and intoxication and carry over[J].Food and Chemical Toxicology,2013,60:58-75.

[56] DÄNICKE S,BROSIG B,KAHLERT S,et al.The plasma clearance of the Fusarium toxin deoxynivalenol (DON) is decreased in endotoxemic pigs[J].Food and Chemical Toxicology,2012, 50(12):4405-4411.  

[57] GOYARTS T,BRVSSOW K P,VALENTA H,et al.On the effects of the Fusarium toxin deoxynivalenol (DON) administered per os or intraperitoneal infusion to sows during days 63 to 70 of gestation[J].Mycotoxin Research,2010,26(2):119-131.  

[58] WU Q H,WANG X,YANG W,et al.Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans:an update[J].Archives of Toxicology,2014,88(7):1309-1326.  

[59] YOSHIZAWA T,TAKEDA H,OHI T.Structure of a novel metabolite from deoxynivalenol, a trichothecene mycotoxin,in animals[J].Agricultural and Biological Chemistry,1983,47(9):2133-2135.  

[60] WORRELL N R,MALLETT A K,COOK W M,et al.The role of gut micro-organisms in the metabolism of deoxynivalenol administered to rats[J].Xenobiotica,1989,19(1):25-32.  

[61] SWANSON S P,NICOLETTI J,ROOD H D,Jr,et al.Metabolism of three trichothecene ycotoxins,T-2 toxin,diacetoxyscirpenol and deoxynivalenol,by bovne rumen microorganisms[J].Journal of Chromatography B: Biomedical Sciences and Applications,1987,414:335-342.

[62] HEDMAN R,PETTERSSON H.Transformation of nivalenol by gastrointestinal microbes[J].Archives of Animal Nutrition,1997,50(4):321-329.

[63] SEELING K,DÄNICKE S,VALENTAET H,et al.Effects of Fusarium toxin-contaminated wheat and feed intake level on the biotransformation and carry-over of deoxynivalenol in dairy cows[J].Food Additives and Contaminants, 2006,23(10):1008-1020.  

[64] GRATZ S W,DUNCAN G,RICHARDSON A J.The human fecal microbiota metabolizes deoxynivalenol and deoxynivalenol-3-glucoside and may be responsible for urinary deepoxy-deoxynivalenol[J].Applied and Environmental Microbiology,2013,79(6):1821-1825.  

[65] ITO M,SATO I,ISHIZAKA M,et al.Bacterial cytochrome P450 system catabolizing the Fusarium toxin deoxynivalenol[J].Applied and Environmental Microbiology,2013,79(5):1619-1628.  

[66] WU X,MURPHY P,CUNNICK J,et al.Synthesis and characterization of deoxynivalenol glucuronide:its comparative immunotoxicity with deoxynivalenol[J].Food and Chemical Toxicology,2007,45(10):1846-1855.  

[67] TUKEY R H,STRASSBURG C P.Human UDP-glucuronosyltransferases:metabolism,expression,and disease[J].Annual Review of Pharmacology and Toxicology,2000,40:581-616.

[68] MAUL R,WARTH B,KANT J S,et al.Investigation of the hepatic glucuronidation pattern of the Fusarium mycotoxin deoxynivalenol in various species[J].Chemical Research in Toxicology, 2012,25(12):2715-2717.  

[69] UHLIG S,IVANOVA L,FAESTE C K.Enzyme-assisted synthesis and structural characterization of the 3-,8-,and 15-glucuronides of deoxynivalenol[J].Journal of Agricultural and Food Chemistry,2013,61(8):2006-2012.  

[70] YOUNG J C,TRENHOLM H L,FRIEND D W,et al.Detoxification of deoxynivalenol with sodium bisulfite and evaluation of the effects when pure mycotoxin or contaminated corn was treated and given to pigs[J].Journal of Agricultural and Food Chemistry,1987,35(2):259-261.  

[71] DÄNICKE S,HEGEWALD A K,KAHLERT S,et al.Studies on the toxicity of deoxynivalenol (DON),sodium metabisulfite,DON-sulfonate (DONS) and de-epoxy-DON for porcine peripheral blood mononuclear cells and the Intestinal Porcine Epithelial Cell lines IPEC-1 and IPEC-J2,and on effects of DON and DONS on piglets[J].Food and Chemical Toxicology,2010,48(8/9):2154-2162.

[72] WAN D,HUANG L L,PAN Y H,et al.Metabolism, distribution, and excretion of deoxynivalenol with combined techniques of radiotracing, high-performance liquid chromatography ion trap time-of-flight mass spectrometry,and online radiometric detection[J].Journal of Agricultural and Food Chemistry,2014,62(1):288-96.  

[73] SALIM R.Effect of adsorption on calibration graphs obtained for lead,cadmium and copper in natural water samples[J].Journal of Environmental Science and Health,Part A:Environmental Science and Engineering,1987,22(2):125-139.  

[74] TURNER P C,HOPTON R P,WHITE K L M,et al.Assessment of deoxynivalenol metabolite profiles in UK adults[J].Food and Chemical Toxicology,2011,49(1):132-135.

[75] WARTH B,SULYOK M,FRUHMANN P,et al.Assessment of human deoxynivalenol exposure using an LC-MS/MS based biomarker method[J].Toxicology Letters,2012,211(1):85-90.  

[76] LI Y Q,WANG H,JIA B X,et al.Study of the interaction of deoxynivalenol with human serum albumin by spectroscopic technique and molecular modelling[J].Food Additives and Contaminants,Part A:Chemistry Analysis Control Exposure & Risk Assessment,2013,30(2):356-364.  

[77] VALENTA H,DÄNICKE S.Study on the transmission of deoxynivalenol and de-epoxy-deoxynivalenol into eggs of laying hens using a high-performance liquid chromatography-ultraviolet method with clean-up by immunoaffinity columns[J].Molecular Nutrition & Food Research,2005,49(8):779-785.  

[78] GOYARTS T,DÄNICKE S,VALENTA H,et al.Carry-over of Fusarium toxins (deoxynivalenol and zearalenone) from naturally contaminated wheat to pigs[J].Food Additives & Contaminants,2007,24(4):369-380.  

[79] GOYARTS T,DÄNICKE S,BRVSSOW K P,et al.On the transfer of the Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) from sows to their fetuses during days 35-70 of gestation[J].Toxicology Letters,2007,171(1/2):38-49.
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