综述 Review

miRNAs对热应激畜禽调控的分子机制

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  • 1. 湖南农业大学动物科学技术学院, 长沙 410128;
    2. 中国农业科学院北京畜牧兽医研究所, 动物营养学国家重点实验室, 北京 100193;
    3. 中国农业科学院与世界农用林业中心农用林业与 可持续畜牧业联合实验室, 北京 100193;
    4. 东北农业大学食品安全与 营养协同创新中心, 哈尔滨 150030
郭江(1986-),男,福建三明人,博士研究生,研究方向为动物生理学。E-mail:zhouhui163521@163.com

收稿日期: 2015-10-13

  网络出版日期: 2016-03-14

基金资助

国家自然科学基金(31372341);十二五国家科技支撑计划(2012BAD12B02-05);动物营养学国家重点实验室自主课题(2004DA125184G1103)

Anti-Heatstress Mechanism of miRNAs in Livestock and Poultry

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  • 1. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
    2. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    3. CAAS-ICRAF Joint Laboratory on Agroforestry and Sustainable Animal Husbandry, Beijing 100193, China;
    4. Synergetic Innovation Center of Food Safety and Nutrition, Harbin 150030, China

Received date: 2015-10-13

  Online published: 2016-03-14

摘要

热应激改变动物行为和生理机能,miRNAs作为22个核苷酸左右的非编码RNA,在转录后水平通过抑制靶基因参与机体的热应激调控。本文就miRNAs对热应激细胞生长、凋亡以及对热应激畜禽免疫、抗应激、器官损伤、生长性能和繁殖性能等方面所起作用及其机制进行综述。

关键词: miRNAs; 热应激; 畜禽; 调控

本文引用格式

郭江, 高胜涛, 权素玉, 南雪梅, 卜登攀 . miRNAs对热应激畜禽调控的分子机制[J]. 动物营养学报, 2016 , 28(3) : 652 -658 . DOI: 10.3969/j.issn.1006-267x.2016.03.003

Abstract

Animal behavior and physiological function were changed under heat stress. miRNAs contained approximately 22 nucleotides in length regulated target gene of heat-stressed animal at the post-transcriptional level. This article mainly reviewed the effects of differential miRNAs expression on growth and apoptosis of heat stress cell, and the regulation of miRNAs on immunity, anti-stress responses, organic damage, performance and fertility, etc, and their mechanisms.

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