综述 Review

白藜芦醇对动物表观遗传学调控的作用机制

  • 张卫兵 ,
  • 张蓉 ,
  • 屠焰 ,
  • 刁其玉
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  • 中国农业科学院饲料研究所, 农业部饲料生物技术重点实验室, 奶牛营养学北京市重点实验室, 北京 100081

收稿日期: 2015-11-23

  网络出版日期: 2016-05-24

基金资助

公益性行业(农业)科研专项"南方地区幼龄草食畜禽饲养技术研究(201303143)";奶牛产业技术体系北京市创新团队营养岗位

The Mechanism of Resveratrol in Epigenetics Regulation in Animals

  • ZHANG Weibing ,
  • ZHANG Rong ,
  • TU Yan ,
  • DIAO Qiyu
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  • Feed Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Feed Biotechnology of the Ministry of Agriculture, Beijing Key Laboratory for Dairy Cow Nutrition, Beijing 100081, China

Received date: 2015-11-23

  Online published: 2016-05-24

摘要

白藜芦醇是一种非黄酮类多酚物质,也是一种天然的植物抗毒素,广泛存在于多种植物中。白藜芦醇具有多种生物活性和药理作用,如抗氧化、抗肿瘤、神经及心血管保护和抗衰老等作用。新近研究表明白藜芦醇的这些作用与表观遗传学修饰调控基因的内在表达密切相关。本文总结了表观遗传学主要修饰机制以及白藜芦醇参与动物和人基因DNA甲基化、组蛋白乙酰化、微小RNA等方面的研究进展,从表观遗传学修饰水平方面综述了白藜芦醇在动物和人体内发挥作用的途径。

本文引用格式

张卫兵 , 张蓉 , 屠焰 , 刁其玉 . 白藜芦醇对动物表观遗传学调控的作用机制[J]. 动物营养学报, 2016 , 28(5) : 1302 -1308 . DOI: 10.3969/j.issn.1006-267x.2016.05.003

Abstract

Resveratrol is a kind of non-flavonoid phenolic compounds, and is a kind of natural plant anti-toxin, which widely exists in many plants. Resveratrol has various bioactivities and pharmacological effects, such as antioxidant activity, anticancer activity, neuroprotective activity, cardioprotective capacity and anti-aging activity. Recent studies indicated that these activities were largely accomplished by epigenetic modifications in the regulation of gene expression. In this paper, we summarized the main mechanism of epigenetic modification and the research progress of resveratrol in animals and humans gene DNA methylation, histone acetylation and miRNA. From the aspects of epigenetic modification, we reviewed the pathway of resveratrol in animals and humans.

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