综述 Review

乳腺内氨基酸调控乳蛋白合成的分子作用机制

  • 张牧臣 ,
  • 高海娜 ,
  • 赵圣国 ,
  • 王珊珊 ,
  • 郑楠 ,
  • 王加启
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  • 1. 中国农业科学院北京畜牧兽医研究所, 农业部奶产品质量安全风险评估实验室(北京), 农业部奶及奶制品质量监督检验测试中心(北京), 动物营养学国家重点实验室, 北京 100193;
    2. 甘肃农业大学动物科学技术学院, 兰州 730070;
    3. 内蒙古农业大学动物科学学院, 呼和浩特 010018

收稿日期: 2015-12-01

  网络出版日期: 2016-05-24

基金资助

现代农业产业技术体系专项资金(nycytx-04-01);中国农业科学院科技创新工程(ASTIP-IAS12)

Molecular Mechanisms in Regulation of Milk Protein Synthesis by Amino Acids in Mammary Gland

  • ZHANG Muchen ,
  • GAO Haina ,
  • ZHAO Shengguo ,
  • WANG Shanshan ,
  • ZHENG Nan ,
  • WANG Jiaqi
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  • 1. Ministry of Agriculture-Milk Risk Assessment Laboratory, Ministry of Agriculture-Milk and Dairy Product Inspection Center, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    2. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China;
    3. College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China

Received date: 2015-12-01

  Online published: 2016-05-24

摘要

作为维持哺乳动物生命活动重要的"生物工厂",乳腺利用从流经血液中摄取的氨基酸等营养物质为底物合成乳蛋白。研究证实,氨基酸还可作为一种信号因子,通过乳腺内多种信号级联传导通路,调控乳蛋白基因的转录及翻译过程,从而影响乳腺中乳蛋白的合成。酪氨酸蛋白激酶-信号转导子和转录激活子(JAK-STAT)信号通路和哺乳动物雷帕霉素靶蛋白(mTOR)信号通路是乳蛋白基因转录和翻译过程中的主要调控路径。本文综述了乳腺JAK-STAT和mTOR信号通路的分子机制及氨基酸通过这些通路调控乳蛋白合成的研究进展,旨在进一步阐明氨基酸调控乳蛋白合成的作用机理。

本文引用格式

张牧臣 , 高海娜 , 赵圣国 , 王珊珊 , 郑楠 , 王加启 . 乳腺内氨基酸调控乳蛋白合成的分子作用机制[J]. 动物营养学报, 2016 , 28(5) : 1309 -1316 . DOI: 10.3969/j.issn.1006-267x.2016.05.004

Abstract

As an important ‘biological factory’ to maintain life activities of mammalian, the mammary gland utilizes nutrients, such as amino acids, that uptake from blood as substrates to synthesize milk protein. Studies confirmed that amino acids also can be used as a signal factor to regulate milk protein gene transcription and translation through the signaling cascade pathways in the mammary gland, which affects milk protein synthesis. Janus kinase-signal transducer and activator of transcription (JAK-STAT) and mammalian target of rapamycin (mTOR) signaling pathways are the main regulatory pathways in the process of milk protein gene transcription and translation. The molecular mechanism of the JAK-STAT and mTOR signaling pathways in the mammary gland and research progress on regulation of milk protein synthesis by amino acids through these pathways were reviewed in this paper, with the aim to further clarify the mechanism in regulation of milk protein synthesis by amino acids.

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