综述 Review

肠道内分泌与营养素感应系统

  • 高侃 ,
  • 慕春龙 ,
  • 余凯凡 ,
  • 朱伟云
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  • 江苏省消化道营养与动物健康重点实验室, 南京农业大学消化道微生物研究室, 南京 210095

收稿日期: 2015-12-29

  网络出版日期: 2016-06-27

基金资助

国家重点基础研究发展计划项目(973项目)(2013CB127300);江苏省自然科学基金(BK20130058);教育部博士点基金项目(20130097130005)

Enteroendocrine and Nutrient Sensing System

  • GAO Kan ,
  • MU Chunlong ,
  • YU Kaifan ,
  • ZHU Weiyun
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  • Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, Laboratory of Gastrointestinal Microbiology, Nanjing Agricultural University, Nanjing 210095, China

Received date: 2015-12-29

  Online published: 2016-06-27

摘要

动物肠道内消化代谢产生的各种营养素或其他化学物质,能够通过肠道内分泌和营养素感应系统发挥生理效应。作为肠道内分泌和营养素感应系统重要的组成部分,肠道内分泌细胞通过表面的感应受体(氨基酸感应受体、脂肪酸感应受体和葡萄糖感应受体等),识别感应肠道内各类营养素,不仅调节营养素吸收和代谢,同时能够分泌脑肠肽(胰高血糖素样肽-1、酪酪肽、胆囊收缩素等)。脑肠肽通过由中枢神经系统、自主神经系统以及肠神经系统构成的脑肠神经网络,参与调控机体摄食行为及其他生理功能。本文就动物肠道内分泌系统、脑肠轴以及营养素感应受体等方面研究进展进行综述。

本文引用格式

高侃 , 慕春龙 , 余凯凡 , 朱伟云 . 肠道内分泌与营养素感应系统[J]. 动物营养学报, 2016 , 28(6) : 1633 -1640 . DOI: 10.3969/j.issn.1006-267x.2016.06.001

Abstract

A variety of nutrients and chemicals in the gastrointestinal (GI) tract exert physiologic effects via enteroendocrine and nutrient sensing system. As a part of enteroendocrine and nutrient sensing system, enteroendocrine cells can detect luminal nutrients via nutrient sensing receptors (amino acids sensing receptors, fatty acids sensing receptors, glucose sensing receptors, etc.). Enteroendocrine cells not only can regulate nutrient absorption and metabolism, but also can secret kinds of gut-brain peptides (glucagon-like peptide-1, peptide YY and cholecystokinin, etc.). Gut-brain peptides through the gut-brain axis, which is composed of central neuron system, automatic nervous system and enteric nervous system, regulate host feeding behaviors and other physiologic functions. This review summarized recent advances on animal enteroendocrine system, gut-brain axis and nutrient sensing receptors.

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