综述 Review

抵抗素诱导肥胖机体胰岛素抵抗的炎症机制

  • 王正义 ,
  • 甘霖莉 ,
  • 左之才
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  • 四川农业大学动物医学院, 雅安 625014

收稿日期: 2015-12-17

  网络出版日期: 2016-06-27

基金资助

四川省科技厅支撑项目(2013NZ0032)

Inflammatory Mechanism of Resistin Induced Insulin Resistance in Obesity

  • WANG Zhengyi ,
  • GAN Linli ,
  • ZUO Zhicai
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  • Key Laboratory of Environmental Hazard and Animal Disease of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China

Received date: 2015-12-17

  Online published: 2016-06-27

摘要

抵抗素是一种脂肪因子,被证明与胰岛素抵抗密切相关,但其作用机制尚不明确。近年研究表明抵抗素参与了肥胖有关的炎症进程,对胰岛素敏感组织(脂肪、肝脏)炎症状态起到重要调控作用。肥胖诱导的慢性低度炎症是导致机体胰岛素抵抗的重要因素,抵抗素通过对炎症的调控参与肥胖机体胰岛素抵抗的发生。本文主要从组织及分子层面探讨抵抗素诱导胰岛素抵抗的炎症机制,为进一步了解抵抗素在肥胖相关疾病病理机制中的作用提供一些思路。

本文引用格式

王正义 , 甘霖莉 , 左之才 . 抵抗素诱导肥胖机体胰岛素抵抗的炎症机制[J]. 动物营养学报, 2016 , 28(6) : 1670 -1676 . DOI: 10.3969/j.issn.1006-267x.2016.06.006

Abstract

Resistin is regarded as being closely related with insulin resistance, but its mechanism is still unclear. Recent studies have indicated that resistin plays an important role in obesity-related subclinical inflammation, especially in insulin sensitive tissues, such as fat and liver. Obesity-induced chronic low-grade inflammation is one of the important factors leading to insulin resistance, and resistin promotes insulin resistance may partly through its inflammatory effects. To provide new ideas for further understanding the effects of resistin on the pathological mechanism of obesity-related diseases, the inflammatory mechanism of resistin-induced insulin resistance in cellular and molecular levels were reviewed in this article.

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