综述 Review

microRNA在反刍动物中的研究进展

  • 翟博 ,
  • 张立春 ,
  • 李旭 ,
  • 王春昕 ,
  • 赵云辉 ,
  • 张明新
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  • 吉林省农业科学院畜牧科学分院, 公主岭 136100

收稿日期: 2016-01-29

  网络出版日期: 2016-07-28

基金资助

国家863资助项目(2013AA102506);国家绒毛用羊产业技术体系(CARS40-16);国家科技支撑计划子课题(2011BAD28B05-1-5);吉林省博士后科研人员科研项目资助(0010424);吉林省农业科学院博士后科研项目资助(2060599)

Research Progress of MicroRNA in Ruminants

  • ZHAI Bo ,
  • ZHANG Lichun ,
  • LI Xu ,
  • WANG Chunxin ,
  • ZHAO Yunhui ,
  • ZHANG Mingxin
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  • Branch of Animal Husbandry, Jilin Academy of Agricultural Sciences, Gongzhuling 136100, China

Received date: 2016-01-29

  Online published: 2016-07-28

摘要

微小RNA(microRNA,miRNA)是一类长度在22个核苷酸左右的小分子非编码RNA,通过与3’端非翻译区的碱基配对靶向调节mRNA的表达从而抑制其翻译或降解。miRNA广泛存在于动物和植物中,可以参与调节多种发育调控和生物学过程,本文在总结miRNA的来源、作用机制、预测方法及其基因表达与功能的基础上,综述了其在反刍动物中的研究进展。

本文引用格式

翟博 , 张立春 , 李旭 , 王春昕 , 赵云辉 , 张明新 . microRNA在反刍动物中的研究进展[J]. 动物营养学报, 2016 , 28(7) : 1975 -1980 . DOI: 10.3969/j.issn.1006-267x.2016.07.001

Abstract

MicroRNAs (miRNAs) are around 22 nucleotides non-coding RNA that target to the base-pairing 3' untranslated region (UTR) of specific mRNAs and inhibit their translation or degradation. MiRNAs widely exist in animals and plants and may play important roles in the regulations of developmental and physiological processes. This review summarized the biogenesis, mechanism and prediction methods of miRNAs, and their gene expressions and functions, and focused on research progress in ruminants.

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