李美荃 , 刘红 , 张春勇 , 安清聪 , 骆雪 , 陈克嶙 , 郭荣富 . 防御素基因在乌金猪与约大乌猪组织中的表达及东亚飞蝗抗菌活性物质对防御素基因表达的调节作用[J]. 动物营养学报, 2016 , 28(7) : 2096 -2105 . DOI: 10.3969/j.issn.1006-267x.2016.07.014

[1] YANG D,BIRAGYN A,KWAK L W,et al.Mammalian defensins in immunity:more than just microbicidal[J].Trends in Immunology,2002,23(6):291-296.  
[2] DIAMOND G,ZASLOFF M,ECK H,et al.Tracheal antimicrobial peptide,a cysteine-rich peptide from mammalian tracheal mucosa:peptide isolation and cloning of a cDNA[J].Proceedings of the National Academy of Sciences of the United States of America,1991,88(9):3952-3956.  
[3] HERRERA R,MORRIS M,ROSBE K,et al.Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cells[J].Virology,2016,487:172-187.
[4] KALLó G,CHATTERJEE A,TóTH M,et al.Relative quantification of human β-defensins by a proteomics approach based on selected reaction monitoring[J].Rapid Communications in Mass Spectrometry,2015,29(18):1623-1631.  
[5] 骆雪,张春勇,陈克嶙,等.东亚飞蝗抗菌活性物质的萃取及抗菌效应研究[J].家畜生态学报,2013,34(2):53-57.
[6] 温刘发,张常明,付林,等.抗菌肽制剂代替抗生素在断奶仔猪饲粮中的应用效果[J].中国饲料,2001(18):13-14.
[7] PFAFFL M W.A new mathematical model for relative quantification in real-time RT-PCR[J].Nucleic Acids Research,2001,29(9):e45.
[8] 何万涛,舒永霞.人免疫球蛋白外敷治疗皮肤过敏的疗效观察[J].内蒙古中医药,2011,30(18):103-104.
[9] 卢亚萍,潘宏涛,纪孙瑞.溶菌酶对仔猪生长性能及血清生化指标的影响[J].养猪,2010(4):30-31.
[10] VELDHUIZEN E J,VAN DIJK A,TERSTEEG M H G,et al.Expression of β-defensins pBD-1 and pBD-2 along the small intestinal tract of the pig:lack of upregulation in vivo upon Salmonella typhimurium infection[J].Molecular Immunology,2007,44(4):276-283.  
[11] SANG Y M,PATIL A A,ZHANG G L,et al.Bioinformatic and expression analysis of novel porcine β-defensins[J].Mammalian Genome,2006,17(4):332-339.  
[12] CAVERLY J M,DIAMOND G,GALLUP J M,et al.Coordinated expression of tracheal antimicrobial peptide and inflammatory-response elements in the lungs of neonatal calves with acute bacterial pneumonia[J].Infection and Immunity,2003,71(5):2950-2955.  
[13] MEYERHOLZ D K,GALLUP J M,GRUBOR B M,et al.Developmental expression and distribution of sheep β-defensin-2[J].Developmental & Comparative Immunology,2004,28(2):171-178.  
[14] 安沙,韩菲菲,高彦华,等.β-防御素在金华猪和长白猪肠道中表达规律的研究[J].动物营养学报,2011,23(10):1762-1768.
[15] 邹锋.家蝇抗菌肽生产及制剂研究[D].硕士学位论文.长沙:湖南农业大学,2007.
[16] 索相敏,陆秀君,董建臻,等.2种昆虫高活性抗菌肽制备方法的优化[J].华北农学报,2007,22(3):119-122.
[17] 骆雪,张春勇,安清聪,等.L-精氨酸对猪胎儿皮肤成纤维细胞免疫应激参数和β防御素基因mRNA表达的影响[J].动物营养学报,2013,25(5):1037-1044.
[18] MCCAFFERTY D M,MUDGETT J S,SWAIN M G,et al.Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation[J].Gastroenterology,1997,112(3):1022-1027.  
[19] JANEWAY C A,J.,MEDZHITOV R.Innate immune recognition[J].Annual Review of Immunology,2002,20:197-216.
[20] RUSSELL J P,BEVINS C L.Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells[J].Proceedings of the National Academy of Sciences of the United States of America,1996,93(10):5156-5160.  
[21] RATHINAKUMAR R,WIMLEY W C.High-throughput discovery of broad-spectrum peptide antibiotics[J].The FASEB Journal,2010,24(9):3232-3238.