饲料营养 Feed Science and Technology

阿魏酸对ob/ob小鼠脂肪沉积及腹脂脂肪酸组成的影响

  • 潘奕鸥 ,
  • 王薇薇 ,
  • 李爱科 ,
  • 张卫卫 ,
  • 韩四海 ,
  • 刘建学
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  • 1. 河南科技大学食品与生物工程学院, 洛阳 471023;
    2. 国家粮食局科学研究院, 北京 100037;
    3. 河南省食品原料工程技术研究中心, 洛阳 471023

收稿日期: 2016-01-25

  网络出版日期: 2016-07-28

基金资助

公益性(粮食)行业专项“粮油营养健康特性研究与基础参数数据库的构建”(201313011-6);河南省重点攻关项目“农产品加工副产物的高效增值和循环利用关键技术研究”(142102310262)

Effects of Ferulic Acid on Lipid Deposition and Fatty Acid Composition in Abdominal Lipid of ob/ob Mice

  • PAN Yiou ,
  • WANG Weiwei ,
  • LI Aike ,
  • ZHANG Weiwei ,
  • HAN Sihai ,
  • LIU Jianxue
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  • 1. College and Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China;
    2. Academy of State of Administration of Grain, Beijing 100037, China;
    3. Henan Engineering Research Center of Food Material, Luoyang 471023, China

Received date: 2016-01-25

  Online published: 2016-07-28

摘要

本试验旨在研究阿魏酸对ob/ob小鼠脂肪沉积和腹脂脂肪酸组成的影响。选取5周龄的雄性ob/ob小鼠30只,随机分为3组(n=10),分别饲喂在基础饲粮中添加0(对照组)、0.25%和0.50%阿魏酸的试验饲粮,试验期9周。结果表明:与对照组相比,饲粮中添加0.25%和0.50%的阿魏酸显著降低了ob/ob小鼠的总增重、腹脂率(P<0.05),显著降低了血清甘油三酯及肝脏甘油三酯和总胆固醇水平(P<0.05),减少了肝脏脂滴积累,显著降低了腹脂中棕榈油酸和油酸的含量(P<0.05),显著降低了腹脂中棕榈油酸/棕榈酸和油酸/硬脂酸(P<0.05)。由此得出,阿魏酸可以抑制ob/ob小鼠的脂肪沉积,改善其腹脂脂肪酸组成,减重降脂效果明显。

本文引用格式

潘奕鸥 , 王薇薇 , 李爱科 , 张卫卫 , 韩四海 , 刘建学 . 阿魏酸对ob/ob小鼠脂肪沉积及腹脂脂肪酸组成的影响[J]. 动物营养学报, 2016 , 28(7) : 2140 -2146 . DOI: 10.3969/j.issn.1006-267x.2016.07.019

Abstract

This experiment was conducted to study the effects of ferulic acid (FA) on lipid deposition and fatty acid composition in abdominal lipid of ob/ob mice. A total of 30 male ob/ob mice at 5 weeks old were randomly divided into 3 groups (n=10). ob/ob mice in the 3 groups were fed the basal diets supplemented with 0 (control group), 0.25% and 0.50% FA, respectively. The experiment lasted for 9 weeks. The results showed that compared with control group, FA significantly reduced the total weight gain and abdomen fat percentage (P<0.05), significantly lessened the serum TG and liver TG and TC levels (P<0.05), attenuated accumulation of lipid droplet, significantly suppressed the contents of palmitoleic acid and oleic acid in abdominal lipid(P<0.05), and significantly decreased the desaturation indexes-palmitoleic acid/palmitic acid and oleic acid/ stearic acid in abdominal lipid (P<0.05). It is concluded that FA can inhibit the lipid deposition and ameliorate the fatty acid composition in abdominal lipid, and the weight-reducing and lipid-lowering effect is obvious.

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