综述 Review

氧化应激与自噬

  • 吴艳萍 ,
  • 王阳 ,
  • 李雅丽 ,
  • 曹雪芳 ,
  • 李卫芬
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  • 浙江大学动物科学学院饲料科学研究所, 教育部动物分子营养学重点实验室, 杭州 310058

收稿日期: 2016-03-21

  网络出版日期: 2016-09-08

基金资助

国家863计划项目(2013AA102800);国家自然科学基金项目(31472128)

Oxidative Stress and Autophagy

  • WU Yanping ,
  • WANG Yang ,
  • LI Yali ,
  • CAO Xuefang ,
  • LI Weifen
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  • Key Laboratory of Molecular Animal Nutrition of Ministry of Education, Institute of Feed Science, College of Animal Science, Zhejiang University, Hangzhou 310058, China

Received date: 2016-03-21

  Online published: 2016-09-08

摘要

自噬是细胞依赖溶酶体对蛋白质和细胞器进行降解的过程,能帮助细胞适应各种不良刺激,在维持细胞内环境稳态和实现自我更新中起着重要作用。氧化应激是机体氧化和抗氧化系统之间的稳态被破坏而造成的应激状态。大量研究表明,氧化应激中产生的活性氧能诱导自噬产生,而自噬能缓解氧化应激造成的损伤,从而保护细胞存活。本文主要对自噬的形成过程、氧化应激诱导自噬产生机制以及自噬缓解氧化应激的途径等进行综述,以期为畜牧生产中通过调控自噬缓解氧化应激提供理论依据。

本文引用格式

吴艳萍 , 王阳 , 李雅丽 , 曹雪芳 , 李卫芬 . 氧化应激与自噬[J]. 动物营养学报, 2016 , 28(9) : 2673 -2680 . DOI: 10.3969/j.issn.1006-267x.2016.09.002

Abstract

Autophagy is a lysosome-dependent process aimed at degrading proteins and damaged organelles, in order to preserve cellular homeostasis and self-recycling in diverse conditions of stress. Oxidative stress, is a stress status when the balance of oxidation and anti-oxidation system breaks down, which subsequently cause cellular damage. A growing amount of evidence demonstrate that reactive oxygen species (ROS) generated in oxidative stress is a main inducer of autophagy, and autophagy, in turn, serves to reduce oxidative damage and enhances cell survival. This article mainly described the process of autophagy, the mechanism of autophagy induction by oxidative stress and the pathway of antioxidant function mediated by autophagy. We attempt to provide a theoretical basis of attenuating oxidative stress in livestock production through regulating autophagy.

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