综述 Review

脂联素及其受体对脂代谢信号转导通路的调控机制

  • 孟博 ,
  • 范芮铭 ,
  • 栾新红
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  • 沈阳农业大学畜牧兽医学院, 沈阳 110866

收稿日期: 2016-05-12

  网络出版日期: 2016-10-17

基金资助

国家自然科学基金项目(31372395)

Regulation Mechanism of Adiponectin and Its Receptors on Lipid Metabolism Signal Transduction Pathways

  • MENG Bo ,
  • FAN Ruiming ,
  • LUAN Xinhong
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  • College of Veterinary and Animal Science, Shenyang Agricultural University, Shenyang 110866, China

Received date: 2016-05-12

  Online published: 2016-10-17

摘要

脂联素(AdipoQ)是一种由脂肪组织分泌的细胞因子,在调节畜禽的脂代谢等方面具有重要作用。AdipoQ主要通过与脂联素受体1(AdipoR1)和脂联素受体2(AdipoR2)2种受体结合来调控腺苷酸活化蛋白激酶α(AMPKα)、p38丝裂原激活蛋白激酶(p38MARK)和过氧化物酶体增殖物激活受体α(PPARα)等信号转导通路,参与机体内的脂代谢途径。目前对AdipoQ介导的脂代谢信号转导通路的研究已有了一定进展。本文就AdipoQ及其受体的结构,以及AdipoQ及其受体对脂代谢的调控机制进行了综述。

本文引用格式

孟博 , 范芮铭 , 栾新红 . 脂联素及其受体对脂代谢信号转导通路的调控机制[J]. 动物营养学报, 2016 , 28(10) : 3059 -3063 . DOI: 10.3969/j.issn.1006-267x.2016.10.006

Abstract

Adiponectin (AdipoQ) is one of cytokines secreted by adipose tissue, which plays an important role in regulating lipid metabolism of livestock and poultry. AdipoQ regulates adenosine 5'-monophosphate-activated protein kinase α (AMPKα), p38 mitogen-activated protein kinase (p38MARK) and peroxisome proliferator activated receplor-α (PPARα)to participate their signal transduction pathways mainly through binding adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2), which is associated with regulating lipid metabolism. At present, there has been some progress in the research on the lipid metabolism signaling transduction pathways mediated by AdipoQ. In this paper, the structures of AdipoQ and its receptors, as well as the regulation mechanism of lipid metabolism mediated by AdipoQ and its receptors were reviewed.

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