综述 Review

Wnt/β-连环蛋白信号通路在哺乳动物子宫发育中的调控作用及其机制

  • 杨立杰 ,
  • 杨维仁 ,
  • 黄丽波 ,
  • 冯强 ,
  • 姜淑贞 ,
  • 杨在宾
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  • 1. 山东农业大学动物科技学院, 泰安 271018;
    2. 泰安市中心医院, 泰安 271000

收稿日期: 2016-03-28

  网络出版日期: 2016-10-17

基金资助

国家自然科学基金资助项目(31572441)

Regulation and Mechanism of Wnt/β-Catenin on the Development of Uterus in Mammals

  • YANG Lijie ,
  • YANG Weiren ,
  • HUANG Libo ,
  • FENG Qiang ,
  • JIANG Shuzhen ,
  • YANG Zaibin
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  • 1. College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China;
    2. Tai'an Central Hospital, Tai'an 271000, China

Received date: 2016-03-28

  Online published: 2016-10-17

摘要

机体内生理活动程序化的有序运行均依赖于不同信号传导通路之间的相互协调,其中Wnt(名称来源于果蝇无翅基因Wingless和小鼠致癌基因int-1)信号通路受到学者们的广泛关注,已经成为分子生物学和细胞生物学领域的研究热点。本文研究了Wnt/β-连环蛋白(β-catenin)信号通路在哺乳动物子宫发育中的调控作用及其机制,综述了糖原合酶激酶-3β(GSK-3β)、结肠腺瘤样息肉基因(APC)、支架蛋白(Axin)和成骨细胞抑制因子(Dkk)对Wnt/β-catenin信号通路的调控机制及Wnt/β-catenin信号通路的核内激活,旨在进一步揭示子宫内调节机制,并为子宫疾病的治疗提供借鉴。

本文引用格式

杨立杰 , 杨维仁 , 黄丽波 , 冯强 , 姜淑贞 , 杨在宾 . Wnt/β-连环蛋白信号通路在哺乳动物子宫发育中的调控作用及其机制[J]. 动物营养学报, 2016 , 28(10) : 3070 -3075 . DOI: 10.3969/j.issn.1006-267x.2016.10.008

Abstract

The orderly operation of the physiological activity program within the body depends on the coordination among different signal transduction pathways. Wnt (name derived from the Drosophila gene Wingless and mouse oncogene int-1) signaling pathway has received extensive attention of scholars and became a research hotspots in the fields of molecular biology and cell biology. In this paper, regulation and mechanism of Wnt/β-catenin signaling pathway on development of uterus in mammals were studied. The paper reviewed the regulating mechanism of glycogen synthase kinase 3β (GSK-3β), adenomatous polyposis coli (APC), scaffold protein (Axin) and osteoblast inhibitory factor (Dkk) on Wnt/β-catenin signaling pathway and intranuclear activated of Wnt/β-catenin signaling pathway, to further revealed the regulating mechanism in the uterus, and provided reference for the treatment of uterine diseases.

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