[1] BOISEN S,HVELPLUND T,WEISBJERG M R.Ideal amino acid profiles as a basis for feed protein evaluation[J].Livestock Production Science,2000,64(2/3):239-251.
[2] SHRIVER J A,CARTER S D,SUTTON A L,et al.Effects of adding fiber sources to reduced-crude protein,amino acid-supplemented diets on nitrogen excretion,growth performance,and carcass traits of finishing pigs[J].Journal of Animal Science,2003,81(2):492-502.
[3] LORDELO M M,GASPAR A M,LE BELLEGO L,et al.Isoleucine and valine supplementation of a low-protein corn-wheat-soybean meal-based diet for piglets:growth performance and nitrogen balance[J].Journal of Animal Science,2008,86(11):2936-2941.
[4] YIN Y L,HUANG R L,LI T J,et al.Amino acid metabolism in the portal-drained viscera of young pigs:effects of dietary supplementation with chitosan and pea hull[J].Amino Acids,2010,39(5):1581-1587.
[5] ZHANG G J,SONG Q L,XIE C Y,et al.Estimation of the ideal standardized ileal digestible tryptophan to lysine ratio for growing pigs fed low crude protein diets supplemented with crystalline amino acids[J].Livestock Science,2012,149(3):260-266.
[6] GALLO L,DALLA MONTÀ G,CARRARO L,et al.Growth performance of heavy pigs fed restrictively diets with decreasing crude protein and indispensable amino acids content[J].Livestock Science,2014,161:130-138.
[7] GLOAGUEN M,LE FLOCH N,CORRENT E,et al.The use of free amino acids allows formulating very low crude protein diets for piglets[J].Journal of Animal Science,2014,92(3):637-644.
[8] GALASSI G,COLOMBINI S,MALAGUTTI L,et al.Effects of high fibre and low protein diets on performance,digestibility,nitrogen excretion and ammonia emission in the heavy pig[J].Animal Feed Science and Technology,2010,161(3/4):140-148.
[9] PATRÁŠ P,NITRAYOVÁ S,BRESTENSKŸ M,et al.Effect of dietary fiber and crude protein content in feed on nitrogen retention in pigs[J].Journal of Animal Science,2015,90(S4):158-160.
[10] ROTZ C A.Management to reduce nitrogen losses in animal production[J].Journal of Animal Science,2004,82(E-Suppl):E119-E137.
[11] PUIMAN P,STOLL B,MØLBAK L,et al.Modulation of the gut microbiota with antibiotic treatment suppresses whole body urea production in neonatal pigs[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2013,304(3):G300-G310.
[12] HITOSUGI T,FAN J,CHUNG T W,et al.Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism[J].Molecular Cell,2011,44(6):864-877.
[13] NYACHOTI C M,OMOGBENIGUN F O,RADEMACHER M,et al.Performance responses and indicators of gastrointestinal health in early-weaned pigs fed low-protein amino acid-supplemented diets[J].Journal of Animal Science,2006,84(1):125-134.
[14] SHIRALI M,DOESCHL-WILSON A,KNAP P W,et al.Nitrogen excretion at different stages of growth and its association with production traits in growing pigs[J].Journal of Animal Science,2012,90(6):1756-1765.
[15] JØRGENSEN H,PRAPASPONGSA T,VAN THI K V,et al.Models to quantify excretion of dry matter,nitrogen,phosphorus and carbon in growing pigs fed regional diets[J].Journal of Animal Science and Biotechnology,2013,4:42.
[16] KIRCHGESSNER A L.Glutamate in the enteric nervous system[J].Current Opinion in Pharmacology,2001,1(6):591-596.
[17] STOLL B,BURRIN D G.Measuring splanchnic amino acid metabolism
in vivo using stable isotopic tracers[J].Journal of Animal Science,2006,84(Suppl):E60-E72.
[18] ROMERO-GÓMEZ M,JOVER M,GALÁN J J.Gut ammonia production and its modulation[J].Metabolic Brain Disease,2009,24(1):147-157.
[19] WU G.Amino acids:metabolism,functions,and nutrition[J].Amino Acids,2009,37(1):1-17.
[20] EL-SABAGH M,SUGINO T,OBITSU T,et al.Effects of forage intake level on nitrogen net flux by portal-drained viscera of mature sheep with abomasal infusion of an amino acid mixture[J].Animal,2013,7(10):1614-1621.
[21] WU G Y.Functional amino acids in growth,reproduction,and health[J].Advances in Nutrition,2010,1:31-37.
[22] DAM G,KEIDING S,MUNK O L,et al.Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2011,301(2):G269-G277.
[23] 陈澄.日粮蛋白水平对仔猪肝脏氨基酸代谢转化的影响研究[D].硕士学位论文.重庆:西南大学,2015:21-24
[24] REZAEI R,WANG W W,WU Z L,et al.Biochemical and physiological bases for utilization of dietary amino acids by young pigs[J].Journal of Animal Science and Biotechnology,2013,4:7.
[25] BERTHIAUME R,THIVIERGE M C,PATTON R A,et al.Effect of ruminally protected methionine on splanchnic metabolism of amino acids in lactating dairy cows[J].Journal of Dairy Science,2006,89(5):1621-1634.
[26] DOEPEL L,LOBLEY G E,BERNIER J F,et al.Effect of glutamine supplementation on splanchnic metabolism in lactating dairy cows[J].Journal of Dairy Science,2007,90(9):4325-4333.
[27] ROSE C F.Ammonia-lowering strategies for the treatment of hepatic encephalopathy[J].Clinical Pharmacology & Therapeutics,2012,92:321-331.
[28] WIECHETEK M,SOUFFRANT W B,GARWACKI S.Utilization of nitrogen from
15NH
4Cl and[
15N]alanine for urea synthesis in hepatocytes from fed and starved rats[J].International Journal of Biochemistry,1986,18(7):653-657.
[29] KRISTIANSEN R G,ROSE C F,FUSKEVÅG O M,et al.
L-ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation:a novel ammonia-lowering pathway[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2014,307(10):G1024-G1031.
[30] 杨静.甘氨酸和丙氨酸在肝脏中的代谢去向研究[D].硕士学位论文.重庆:西南大学,2016:27-35.
[31] KIGHT C E,FLEMING S E.Oxidation of glucose carbon entering the TCA cycle is reduced by glutamine in small intestine epithelial cells[J].The American Journal of Physiology,1995,268(6):G879-G888.
[32] DIENEL G A,CRUZ N F.Astrocyte activation in working brain:energy supplied by minor substrates[J].Neurochemistry International,2006,48(6/7):586-595.
[33] TORRES F V,HANSEN F,LOCKS-COELHO L D.Increase of extracellular glutamate concentration increases its oxidation and diminishes glucose oxidation in isolated mouse hippocampus:reversible by TFB-TBOA[J].Journal of Neuroscience Research,2013,91(8):1059-1065.
[34] EL BACHA T,LUZ M,DA POIAN A.Dynamic adaptation of nutrient utilization in humans[J].Nature Education,2010,3(9):8.
[35] DEFRONZO R A,TRIPATHY D.Skeletal muscle insulin resistance is the primary defect in type 2 diabetes[J].Diabetes Care,2009,32(Suppl. 2):S157-S163.
[36] KERR D S.Review of clinical trials for mitochondrial disorders:1997-2012[J].Neurotherapeutics,2013,10(2):307-319.
[37] FILLMORE N,LOPASCHUK G D.Targeting mitochondrial oxidative metabolism as an approach to treat heart failure[J].Biochimica et Biophysica Acta (BBA)-Molecular Cell Research,2013,1833(4):857-865.
[38] YAO J,RETTBERG J R,KLOSINSKI L P,et al.Shift in brain metabolism in late onset Alzheimer's disease:implications for biomarkers and therapeutic interventions[J].Molecular Aspects of Medicine,2011,32(4/5/6):247-257.
[39] TENNANT D A,DURÁN R V,GOTTLIEB E.Targeting metabolic transformation for cancer therapy[J].Nature Reviews Cancer,2010,10(4):267-277.
[40] BRICKER D K,TAYLOR E B,SCHELL J C,et al.A mitochondrial pyruvate carrier required for pyruvate uptake in yeast,Drosophila,and humans[J].Science,2012,337(6090):96-100.
[41] VACANTI N M,DIVAKARUNI A S,GREEN C R,et al.Regulation of substrate utilization by the mitochondrial pyruvate carrier[J].Molecular Cell,2014,56(3):425-435.
[42] GRAY L R,SULTANA M R,RAUCKHORST A J,et al.Hepatic mitochondrial pyruvate carrier 1 is required for efficient regulation of gluconeogenesis and whole-Body glucose homeostasis[J].Cell Metabolism,2015,22(4):669-681.
[43] PATEL M S,KOROTCHKINA L G.Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation:complexity of multiple phosphorylation sites and kinases[J].Experimental & Molecular Medicine,2001,33:191-197.
[44] ROCHE T E,BAKER J C,YAN X,et al.Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms[J].Progress in Nucleic Acid Research and Molecular Biology,2001,70:33-75.
[45] SHAN C L,KANG H B,ELF S,et al.Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth[J].Journal of Biological Chemistry,2014,289:21413-21422.
[46] STACPOOLE P W,NAGARAJA N V,HUTSON A D.Efficacy of dichloroacetate as a lactate-lowering drug[J].Journal of Clinical Pharmacology,2003,43(7):683-691.
[47] BONNET S,ARCHER S L,ALLALUNIS-TURNER J,et al.A mitochondria-K
+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth[J].Cancer Cell,2007,11(1):37-51.
[48] SUN Y,LI T,XIE C,et al.Dichloroacetate treatment improves mitochondrial metabolism and reduces brain injury in neonatal mice[J].Oncotarget,2016,doi:10.18632/oncotarget.9150.
[49] YANG C D,KO B,HENSLEY C T,et al.Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport[J].Molecular Cell,2014,56(3):414-424.
京公网安备 11010802041926号