综述

血根碱的作用机制及其在动物营养上的应用效果

  • 张卫兵 ,
  • 张蓉 ,
  • 屠焰 ,
  • 刁其玉
展开
  • 中国农业科学院饲料研究所, 农业部饲料生物技术重点实验室, 奶牛营养学北京市重点实验室, 北京 100081

收稿日期: 2016-07-04

  网络出版日期: 2017-01-16

基金资助

公益性行业(农业)科研专项“南方地区幼龄草食畜禽饲养技术研究(201303143)”;奶牛产业技术体系北京市创新团队营养岗位

Sanguinarine: Mechanism and Its Application in Animal Feeding

  • ZHANG Weibing ,
  • ZHANG Rong ,
  • TU Yan ,
  • DIAO Qiyu
Expand
  • Beijing Key Laboratory for Dairy Cow Nutrition, Key Laboratory of Feed Biotechnology of the Ministry of Agriculture, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China

Received date: 2016-07-04

  Online published: 2017-01-16

摘要

血根碱是一种苯菲啶异喹啉类生物碱,具有抗菌、抗氧化以及抗炎症的作用,并被用来控制血吸虫,此外血根碱还具有抗肿瘤特性。血根碱作为饲料添加剂,在猪禽饲养管理中替代抗生素已取得了良好效果。本文就对血根碱的主要作用及其机制,以及其在动物营养上的应用进行综述。

本文引用格式

张卫兵 , 张蓉 , 屠焰 , 刁其玉 . 血根碱的作用机制及其在动物营养上的应用效果[J]. 动物营养学报, 2017 , 29(1) : 27 -33 . DOI: 10.3969/j.issn.1006-267x.2017.01.004

Abstract

Sanguinarine is a benzene phenanthridine isoquinoline alkaloid which exhibits antimicrobial, anti-inflammatory and antioxidant properties, and is used to control schistosomiasisi. In addition, sanguinarine also has anti-tumor properties. As feed additives, in swine and poultry feeding, sanguinarine could replace antibiotics and achieve good results. This paper reviewed the main biological functions of sanguinarine and its mechanism of sanguinarine and its application in animal feeding.

参考文献

[1] CUSHNIE T P T,CUSHNIE B,LAMB A J.Alkaloids:an overview of their antibacterial,antibiotic-enhancing and antivirulence activities[J].International Journal of Antimicrobial Agents,2014,44(5):377-386.  
[2] LU J J,BAO J L,CHEN X P,et al.Alkaloids Isolated from natural herbs as the anticancer agents[J].Evidence-Based Complementary and Alternative Medicine,2012,2012:485042.
[3] 伍勇.血根碱在大鼠、猪和鸡的体外代谢研究[D].博士学位论文.长沙:湖南农业大学,2013.
[4] SINGH C K,KAUR S,GEORGE J,et al.Molecular signatures of sanguinarine in human pancreatic cancer cells:a large scale label-free comparative proteomics approach[J].Oncotarget,2015,6(12):10335-10348.  
[5] LIU Y,JIAO R,MA Z G,et al.Sanguinarine inhibits angiotensin Ⅱ induced apoptosis in H9c2 cardiac cells via restoring reactive oxygen species mediated decreases in the mitochondrial membrane potential[J].Molecular Medicine Reports,2015,12(3):3400-3408.
[6] MITSCHER L A,PARK Y H,CLARK D,et al.Antimicrobial agents from higher plants.An investigation of hunnemannia fumariaefolia pseudoalcoholates of sanguinarine and chelerythrine[J].Lloydia,1978,41(2):145-150.
[7] ARORA D,SHARMA A.A review on phytochemical and pharmacological potential of genus Chelidonium[J].Pharmacognosy Journal,2013,5(4):184-190.  
[8] OBIANG-OBOUNOU B W,KANG O H,CHOI J G,et al.The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus[J].The Journal of Toxicological Sciences,2011,36(3):277-283.  
[9] BOULWARE R T,SOUTHARD G L,YANKELL S L.Sanguinaria extract,a new agent for the control of volatile sulfur compounds in the oral cavity[J].Journal of the Society of Cosmetic Chemists,1985,36(4):297-302.
[10] 王静慧,韩剑众,曲道峰.血根碱体外抑菌作用及其对细菌生物被膜的影响[J].中国畜牧杂志,2012,48(19):67-70.
[11] BEURIA T K,SANTRA M K,PANDA D.Sanguinarine blocks cytokinesis in bacteria by inhibiting FtsZ assembly and bundling[J].Biochemistry,2005,44(50):16584-16593.  
[12] SAEIDNIA S,ABDOLLAHI M.Antioxidants:friends or foe in prevention or treatment of cancer:the debate of the century[J].Toxicology and Applied Pharmacology,2013,271(1):49-63.  
[13] BALDWIN A S,Jr.The NF-κB and IκB proteins:new discoveries and insights[J].Annual Review of Immunology,1996,14(1):649-681.  
[14] CHATURVEDI M M,KUMAR A,DARNAY B G,et al.Sanguinarine (Pseudochelerythrine) is a potent inhibitor of NF-κB activation,IkBα phosphorylation,and degradation[J].The Journal of Biological Chemistry,1997,272(48):30129-30134.  
[15] WHO.Cancer[EB/OL].2013-1-10[2016-06-01].http://www.who.int/mediacentre/factsheets/fs297/en/index.html.
[16] BADAL S,DELGODA R.Role of the modulation of CYP1A1 expression and activity in chemoprevention[J].Journal of applied Toxicology,2014,34(7):743-753.  
[17] AHSAN H,REAGAN-SHAW S,BREUR J.Sanguinarine induces apoptosis of human pancreatic carcinoma AsPC-1 and BxPC-3 cells via modulations in Bcl-2 family proteins[J].Cancer Letters,2007,249(2):198-208.  
[18] CHANG M C,CHAN C P,WANG Y J,et al.Induction of necrosis and apoptosis to KB cancer cells by sanguinarine is associated with reactive oxygen species production and mitochondrial membrane depolarization[J].Toxicology and Applied Pharmacology,2007,218(2):143-151.  
[19] KIM S,LEE T J,CHOI K S,et al.Sanguinarine-induced apoptosis:generation of ROS,down-regulation of Bcl-2,c-FLIP,and synergy with trail[J].Journal of Cellular Biochemistry,2008,104(3):895-907.  
[20] HUH J,LIEPINS A,ZIELONKA J,et al.Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity[J].Cancer Research,2006,66(7):3726-3736.  
[21] AHSAN H,REAGAN-SHAW S,EGGERT D M,et al.Protective effect of sanguinarine on ultraviolet B-mediated damages in SKH-1 hairless mouse skin:implications for prevention of skin cancer[J].Photochemistry and Photobiology,2007,83(4):986-993.  
[22] JANG B C,PARK J G,SONG D K,et al.Sanguinarine induces apoptosis in A549 human lung cancer cells primarily via cellular glutathione depletion[J].Toxicology in Vitro,2009,23(2):281-287.  
[23] VOGT A,TAMEWITZ A,SKOKO J,et al.The benzo[c]phenanthridine alkaloid,sanguinarine,is a selective,cell-active inhibitor of mitogen-activated protein kinase phosphatase-1[J].The Journal of Biological Chemistry,2005,280(19):19078-19086.  
[24] LOPUS M,PANDA D.The benzophenanthridine alkaloid sanguinarine perturbs microtubule assembly dynamics through tubulin binding:a possible mechanism for its antiproliferative activity[J].The FEBS Journal,2006,273(10):2139-2150.  
[25] HOLY J,LAMONT G,PERKINS E.Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase Ⅱ by sanguinarine[J].BMC Cell Biology,2006,7(1):13.
[26] SUN M,LIU C F,NADIMINTY N,et al.Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion[J].The Prostate,2012,72(1):82-89.  
[27] ADHAMI V M,AZIZ M H,MUKHTAR H,et al.Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes[J].Clinical Cancer Research,2003,9(8):3176-3182.
[28] 林海,薛立群,杨青.血根碱抗肿瘤作用研究进展[J].动物医学进展,2014,35(5):105-107.
[29] YANG S,XIANG J F,YANG Q F,et al.Distinct G-quadruplex structures of human telomeric DNA formed by the induction of sanguinarine and nitidine under salt-deficient condition[J].Fitoterapia,2010,81(8):1026-1032.  
[30] KAMINSKYY V,LIN K W,FILYAK Y,et al.Differential effect of sanguinarine,chelerythrine and chelidonine on DNA damage and cell viability in primary mouse spleen cells and mouse leukemic cells[J].Cell Biology International,2008,32(2):271-277.  
[31] CIRCU M L,AW T Y.Reactive oxygen species,cellular redox systems,and apoptosis[J].Free Radical Biology and Medicine,2010,48(6):749-762.  
[32] 赵保路.自由基、营养、天然抗氧化剂与衰老[J].生物物理学报,2010,26(1):26-36.
[33] 姚雯,杨天衡,刘学波.血根碱清除自由基及抑制生物大分子氧化的作用[J].食品科学,2014,35(9):137-141.
[34] VARGA Z,CZOMPA A,KAKUK G,et al.Inhibition of the superoxide anion release and hydrogen peroxide formation in PMNLs by flavonolignans[J].Phytotherapy Research,2001,15(7):608-612.  
[35] QIN F Z,PATEL R,YAN C,et al.NADPH oxidase is involved in angiotensin Ⅱ induced apoptosis in H9C2 cardiac muscle cells:effects of apocynin[J].Free Radical Biology and Medicine,2006,40(2):236-246.  
[36] 芦程.血根碱杀灭指环虫机制及对金鱼免疫毒理研究[D].硕士学位论文.杨凌:西北农林科技大学,2013.
[37] DE MORAES J.Natural products with antischistosomal activity[J].Future Medicinal Chemistry,2015,7(6):801-820.  
[38] ZHANG S M,COULTAS K A.Identification of plumbagin and sanguinarine as effective chemotherapeutic agents for treatment of schistosomiasis[J].International Journal for Parasitology:Drugs and Drug Resistance,2013,3:28-34.
[39] 刘铭,彭飞,刘年猛,等.血水草血根碱杀灭钉螺作用的研究[J].实用预防医学,2009,16(3):658-660.
[40] 孙文霞,袁仕善,黄琼瑶,等.血水草血根碱对钉螺肝脏损伤的研究[J].中国血吸虫病防治杂志,2011,23(1):82-84.
[41] ZDARILOVA A,VRUBLOVA E,VOSTALOVA J,et al.Natural feed additive of Macleaya cordata:safety assessment in rats a 90-day feeding experiment[J].Food and Chemical Toxicology,2008,46(12):3721-3726.  
[42] KANTAS D,PAPATSIROS V G,TASSIS P D,et al.The effect of a natural feed additive (Macleaya cordata),containing sanguinarine,on the performance and health status of weaning pigs[J].Animal Science Journal,2015,86(1):92-98.  
[43] 饶华,蔡鹏,周锡红,等.博落回提取物对断奶仔猪生长性能的影响[J].中国兽药杂,2009,43(11):42-45.
[44] 蔡鹏,孙志良,曾建国,等.不同剂量博落回提取物对断奶仔猪生长性能的影响[J].中国畜牧兽医,2010,37(5):41-43.
[45] 林谦,岳龙,刘耕,等.低蛋白饲粮条件下血根碱替代色氨酸对猪生长和代谢的影响[C]//2015中国猪业科技大会暨2015年学术年会.厦门:中国畜牧兽医学会,2015:142.
[46] LEE K W,KIM J S,OH S T,et al.Effects of dietary sanguinarine on growth performance,relative organ weight,cecal microflora,serum cholesterol level and meat quality in broiler chickens[J].The Journal of Poultry Science,2015,52(1):15-22.  
[47] VIEIRA S L,BERRES J,REIS R N,et al.Studies with sanguinarine like alkaloids as feed additive in broiler diets[J].Brazilian Journal of Poultry Science,2008,10(1):67-71.
[48] ABDELNABY E A,MOHAMED M F,GAMMAZ H A K.Pharmacological studies of feed additives (Sanguinarine and Saccharomyces cerevisiae) on growth performance,haematological and intestinal bacterial count with challenge test by Aeromonas hydrophila in Cyprinus carpio[J].Global Animal Science Journal,2013,1(1):1154-1172.
[49] DRSATA J,ULRICHOVÁ J,WALTEROVÁ D.Sanguinarine and chelerythrine as inhibitors of aromatic amino acid decarboxylase[J].Journal of Enzyme Inhibition,1996,10(4):231-237.  
[50] MELLOR S.Natural appetisers from plants[J].Feed Mix,2001,9(1):29-31.
[51] 贺喜,岳龙,张石蕊,等.低蛋白质饲粮中植物源血根碱替代色氨酸对仔猪门静脉血浆流率及氨基酸代谢的影响[J].动物营养学报,2015,27(6):1861-1867.
[52] SARKAR S N.Isolation from argemone oil of dihydrosanguinarine and sanguinarine:toxicity of sanguinarine[J].Nature,1948,162(4111):265-266.  
[53] 张乙涛,王慧.血根碱药理及毒理作用的研究进展[J].中国畜牧兽医,2012,39(7):214-217.
[54] KOSINA P,WALTEROVA D,ULRICHOVÁ J,et al.Sanguinarine and chelerythrine:assessment of safety on pigs in ninety days feeding experiment[J].Food and Chemical Toxicology,2004,42(1):85-91.  
文章导航

/