熊云霞, 马现永, 郑春田, 田志梅, 张健, 陈伟, 胡友军, 王丽 . 热应激对猪肠道健康、免疫系统和肉品质的影响及作用机制[J]. 动物营养学报, 2017 , 29(2) : 374 -381 . DOI: 10.3969/j.issn.1006-267x.2017.02.002

[1] COLLIN A,VAN MILGEN J,DUBOIS S,et al.Effect of high temperature on feeding behaviour and heat production in group-housed young pigs[J].British Journal of Nutrition,2001,86(1):63-70.  

[2] LE BELLEGO L,VAN MILGEN J,NOBLET J.Effect of high temperature and low-protein diets on the performance of growing-finishing pigs[J].Journal of Animal Science,2002,80(3):691-701.  

[3] LEE I K,KYE Y C,KIM G,et al.Stress,nutrition,and intestinal immune responses in pigs-a review[J].Asian Australasian Journal of Animal Sciences,2016,29(8):1075-1082.  

[4] 马现永,蒋宗勇,师子彪,等.热应激对猪生产性能、肉品质的影响及作用机制研究进展[C]//中国猪业科技大会暨中国畜牧兽医学会2015年学术年会论文集.厦门:中国畜牧兽医学会,2015:1.

[5] LAMBERT G P.Intestinal barrier dysfunction,endotoxemia,and gastrointestinal symptoms:the ‘canary in the coal mine’ during exercise-heat stress?[J].Medicine and Sport Science,2008,53(3):61-73.

[6] 贾丹,昝君兰,赵宏,等.热应激对猪小肠组织形态和细胞凋亡的影响[J].北京农学院学报,2012,27(1):36-38.

[7] 胡艳欣,肖冲,佘锐萍,等.热应激对猪肠道结构及功能的影响[J].科学技术与工程,2009,9(3):581-586.

[8] 王洋,杨树宝,董红艳,等.热应激对鹅小肠形态结构及肥大细胞影响的研究[C]//中国畜牧兽医学会动物解剖及组织胚胎学分会第十八次学术研讨会论文集.南京:中国畜牧兽医学会动物解剖及组织胚胎学分会,2014:8.

[9] DOKLADNY K,MOSELEY P L,MA T Y.Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2006,290(2):G204-G212.

[10] DOKLADNY K,YE D M,KENNEDY J C,et al.Cellular and molecular mechanisms of heat stress-induced up-regulation of occludin protein expression:regulatory role of heat shock factor-1[J].The American Journal of Pathology,2008,172(3):659-670.  

[11] PEARCE S C,MANI V,BODDICKER R L,et al.Heat stress reduces barrier function and alters intestinal metabolism in growing pigs[J].Journal of Animal Science,2012,90(Suppl.4):257-259.

[12] PEARCE S C,MANI V,BODDICKER R L,et al.Heat stress reduces intestinal barrier integrity and favors intestinal glucose transport in growing pigs[J].PLoS One,2013,8(8):e70215.

[13] PEARCE S C,MANI V,WEBER T E,et al.Heat stress and reduced plane of nutrition decreases intestinal integrity and function in pigs[J].Journal of Animal Science,2013,91(11):5183-5193.  

[14] YANG P C,HE S H,ZHENG P Y.Investigation into the signal transduction pathway via which heat stress impairs intestinal epithelial barrier function[J].Journal of Gastroenterology and Hepatology,2007,22(11):1823-1831.  

[15] 冯跃进.热应激对猪和大鼠肠道结构和功能的影响及其修复机制[D].硕士学位论文.北京:中国农业科学院,2014:10-27.

[16] MORALES A,HERNÁNDEZ L,BUENABAD L,et al.Effect of heat stress on the endogenous intestinal loss of amino acids in growing pigs[J].Journal of Animal Science,2016,94(1):165-172.  

[17] YU J,YIN P,LIU F H,et al.Effect of heat stress on the porcine small intestine:a morphological and gene expression study[J].Comparative Biochemistry and Physiology Part A:Molecular & Integrative Physiology,2010,156(1):119-128.  

[18] CUI Y J,GU X H.Proteomic changes of the porcine small intestine in response to chronic heat stress[J].Journal of Molecular Endocrinology,2015,55(3):277-293.

[19] PEARCE S C,MAIN V,WEBER T E,等.热应激和低营养摄入对猪肠道完整性和功能的影响[J].中国饲料,2016(3):36-43.

[20] PEARCE S C,LONERGAN S M,HUFF-LONERGAN E,et al.Acute heat stress and reduced nutrient intake alter intestinal proteomic profile and gene expression in pigs[J].PLoS One,2015,10(11):e0143099.

[21] 李永洙,陈常秀,CUI Y Q.热应激对蛋鸡肠道菌群结构、碱性磷酸酶活性及氨基酸转运载体mRNA表达丰度的影响[J].中国农业科学,2013,46(20):4378-4387.

[22] 李永洙,李进,张宁波,等.热应激环境下蛋鸡肠道微生物菌群多样性[J].生态学报,2015,35(5):1601-1609.

[23] 李永洙,陈常秀,金泽林,等.热应激环境下育成鸡肠道菌群多样性及黏膜结构的相关性分析[J].中国农业大学学报,2016,21(1):71-80.

[24] 彭骞骞,王雪敏,张敏红,等.持续偏热环境对肉鸡盲肠菌群多样性的影响[J].中国农业科学,2016,49(1):186-194.

[25] 张盼望.复合益生菌缓解蛋鸡热应激效果及机理研究[D].硕士学位论文.武汉:华中农业大学,2015:13-36.

[26] SONG J,XIAO K,KE Y L,et al.Effect of a probiotic mixture on intestinal microflora,morphology,and barrier integrity of broilers subjected to heat stress[J].Poultry Science,2014,93(3):581-588.  

[27] O'CONNOR T M,O'HALLORAN D J,SHANAHAN F.The stress response and the hypothalamic-pituitary-adrenal axis:from molecule to melancholia[J].QJM:Monthly Journal of the Association of Physicians,2000,93(6):323-333.  

[28] 胡艳欣,佘锐萍,张洪玉,等.热应激后猪血清中IL-2、IFN-γ及TNF-α水平的动态变化[J].畜牧兽医学报,2006,37(5):496-499.

[29] 巨向红,雍艳红,何健嫦,等.热应激对巴马香猪免疫和生化指标的影响[J].中国畜牧杂志,2009,45(13):51-54.

[30] CHEN W L,WANG J L,AN H Z,et al.Heat shock up-regulates TLR9 expression in human B cells through activation of ERK and NF-κB signal pathways[J].Immunology Letters,2005,98(1):153-159.  

[31] 徐汉进.热应激对巴马香猪PBMC TLRs mRNA及TLRs介导的炎症因子表达的影响[D].硕士学位论文.湛江:广东海洋大学,2010:52-84.

[32] JU X H,YONG Y H,XU H J,et al.Selection of reference genes for gene expression studies in PBMC from Bama miniature pig under heat stress[J].Veterinary Immunology and Immunopathology,2011,144(1/2):160-166.

[33] JU X H,YONG Y H,XU H J,et al.Impacts of heat stress on baseline immune measures and a subset of T cells in Bama miniature pigs[J].Livestock Science,2011,135(2/3):289-292.

[34] JU X H,XU H J,YONG Y H,et al.Heat stress upregulation of Toll-like receptors 2/4 and acute inflammatory cytokines in peripheral blood mononuclear cell (PBMC) of Bama miniature pigs:an in vivo and in vitro study[J].Animal,2014,8(9):1462-1468.  

[35] 赵三元,宋金祥,范春艳,等.热应激对肉仔鸡免疫器官发育的影响[J].养禽与禽病防治,2009(12):3-5.

[36] 刘思当,宁章勇,谭勋,等.实验性热应激对肉仔鸡免疫器官的影响[J].中国兽医学报,2003,23(3):281-283.

[37] CUI Y J,HAO Y,LI J L,et al.Chronic heat stress induces immune response,oxidative stress response,and apoptosis of finishing pig liver:a proteomic approach[J].International Journal of Molecular Sciences,2016,17(5):393.

[38] GREGORY N G.How climatic changes could affect meat quality[J].Food Research International,2010,43(7):1866-1873.  

[39] 冯跃进,顾宪红.热应激对猪肉品质的影响及其机制的研究进展[J].中国畜牧兽医,2013,40(2):96-99.

[40] ZHANG Z Y,JIA G Q,ZUO J J,et al.Effects of constant and cyclic heat stress on muscle metabolism and meat quality of broiler breast fillet and thigh meat[J].Poultry Science,2012,91(11):2931-2937.  

[41] SPORER K R,ZHOU H R,LINZ J E,et al.Differential expression of calcium-regulating genes in heat-stressed turkey breast muscle is associated with meat quality[J].Poultry Science,2012,91(6):1418-1424.  

[42] HAO Y,LIU J R,ZHANG Y,et al.The microRNA expression profile in porcine skeletal muscle is changed by constant heat stress[J].Animal Genetics,2016,47(3):365-369.  

[43] HAO Y,CUI Y J,GU X H.Genome-wide DNA methylation profiles changes associated with constant heat stress in pigs as measured by bisulfite sequencing[J].Scientific Reports,2016,6:27507.

[44] YAMAGUCHI T,SUZUKI T,ARAI H,et al.Continuous mild heat stress induces differentiation of mammalian myoblasts,shifting fiber type from fast to slow[J].American Journal of Physiology:Cell Physiology,2010,298(1):C140-C148.

[45] YAMAGUCHI T,OMORI M,TANAKA N,et al.Distinct and additive effects of sodium bicarbonate and continuous mild heat stress on fiber type shift via calcineurin/NFAT pathway in human skeletal myoblasts[J].American Journal of Physiology:Cell Physiology,2013,305(3):C323-C333.

[46] OHNO Y,YAMADA S,GOTO A,et al.Effects of heat stress on muscle mass and the expression levels of heat shock proteins and lysosomal cathepsin L in soleus muscle of young and aged mice[J].Molecular and Cellular Biochemistry,2012,369(1/2):45-53.

[47] 杨培歌,冯跃进,郝月,等.持续高温应激对肥育猪生产性能、胴体性状、背最长肌营养物质含量及肌纤维特性的影响[J].动物营养学报,2014,26(9):2503-2512.

[48] KOUBA M,HERMIER D,LE D J.Influence of a high ambient temperature on lipid metabolism in the growing pig[J].Journal of Animal Science,2001,79(1):81-87.  

[49] QU H,DONKIN S S,AJUWON K M.Heat stress enhances adipogenic differentiation of subcutaneous fat depot-derived porcine stromovascular cells[J].Journal of Animal Science,2015,93(8):3832-3842.  

[50] BAZIZ H A,GERAERT P A,PADILHA J C F,et al.Chronic heat exposure enhances fat deposition and modifies muscle and fat partition in broiler carcasses[J].Poultry Science,1996,75(4):505-513.  

[51] FERNANDEZ M V S,JOHNSON J S,ABUAJAMIEH M,et al.Effects of heat stress on carbohydrate and lipid metabolism in growing pigs[J].Physiological Reports,2015,3(2):e12315.

[52] QU H,YAN H,LU H,et al.Heat stress in pigs is accompanied by adipose tissue-specific responses that favor increased triglyceride storage[J].Journal of Animal Science,2016,94(5):1884-1896.  

[53] SPENCER J D,GAINES A M,BERG E P,et al.Diet modifications to improve finishing pig growth performance and pork quality attributes during periods of heat stress[J].Journal of Animal Science,2005,83(1):243-254.  

[54] 温昊,宋代军,郭志强,等.猪的热应激及营养水平调控[J].饲料工业,2008,29(13):15-18.

[55] 纪少丽,马学会,李爱花.减少猪热应激的营养策略与管理措施[J].中国畜牧杂志,2011,47(16):62-64,67.

[56] 赵洪进,郭定宗.硒和维生素E在热应激猪自由基代谢中的作用[J].中国兽医学报,2005,25(1):78-80.

[57] 杨建,肖芳,郑灿财,等.铬源和铬水平对1-3周龄热应激肉鸡生长性能、胴体性能及肉品质的影响[J].动物营养学报,2015,27(6):1908-1914.

[58] 王胜林,林映才,郑黎,等.抗热应激剂对肥育猪血清生化指标的影响[J].中国畜牧杂志,2003,39(1):11-12.

[59] 王胜林,林映才,蒋宗勇,等.抗热应激剂对高温条件下生长猪生产性能和代谢的影响[J].中国畜牧杂志,2004,40(10):28-30.

[60] 吕晨辉.富硒益生菌对高温条件下仔猪生产性能、抗氧化能力和肠道菌群的影响[D].硕士学位论文.南京:南京农业大学,2013:25-50.

[61] BROOM L J,MILLER H M,KERR K G,et al.Effects of zinc oxide and Enterococcus faecium SF68 dietary supplementation on the performance,intestinal microbiota and immune status of weaned piglets[J].Research in Veterinary Science,2006,80(1):45-54.  

[62] 师子彪.持续高温对肥育猪生产性能和肉质的影响及其机理[D].博士学位论文.广州:中山大学,2015:17-110.