综述 Review

霉菌毒素对多种细胞DNA损伤的研究进展

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  • 1. 中国农业科学院北京畜牧兽医研究所, 动物营养学国家重点实验室, 北京 100193;
    2. 吉林大学食品科学与工程学院, 长春 130022;
    3. 中国农业科学院北京畜牧兽医研究所, 农业部奶及奶制品质量监督检验测试中心, 北京 100193
张焕(1992-),女,吉林白山人,硕士研究生,研究方向为牛奶质量与安全。E-mail:735355610@qq.com

收稿日期: 2016-07-29

  网络出版日期: 2017-02-17

基金资助

国家自然科学基金资助项目(31501399);现代农业产业技术体系专项资金(nycytx-04-01);中国农业科学院科技创新工程(ASTIP-IAS12)

Research Progress of Mycotoxins on DNA Damage of Different Cells

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  • 1. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agriculture Sciences, Beijing 100193, China;
    2. College of Food Science and Engineering, Jilin University, Changchun 130022, China;
    3. Ministry of Agricultural Milk and Dairy Inspection and Supervision Center, Institute of Animal Science, Chinese Academy of Agriculture Sciences, Beijing 100193, China

Received date: 2016-07-29

  Online published: 2017-02-17

摘要

霉菌毒素广泛存在于饲料原料和人类食品中,会对动物和人类健康造成严重威胁,也会对经济效益产生负面影响。霉菌毒素影响细胞的生长,通过增加细胞内活性氧含量造成氧化应激,对细胞DNA造成损伤。本文在国内外已有研究的基础上,对霉菌毒素对肠、肝、肾和神经细胞DNA破坏作用进行综述。

关键词: 霉菌毒素; DNA损伤; 机理

本文引用格式

张焕, 王加启, 高亚男, 郑楠 . 霉菌毒素对多种细胞DNA损伤的研究进展[J]. 动物营养学报, 2017 , 29(2) : 403 -409 . DOI: 10.3969/j.issn.1006-267x.2017.02.006

Abstract

Mycotoxins widely exist in feed ingredients and human food, causing serious economic losses and posing a serious threat to animals or human health. Mycotoxins can affect cells growth, and result in oxidative stress through increase the generation of intracellular reactive oxygen species (ROS), causing DNA damage. Hence, this review summarized the effects of mycotoxins on DNA damage of intestinal, liver, kidney and nerve cells.

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