综述 Review

氨基酸缺乏诱导细胞自噬的哺乳动物雷帕霉素靶蛋白复合体C1信号通路机制研究进展

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  • 1. 四川农业大学动物营养研究所, 成都 611130;
    2. 西南民族大学生命科学与技术学院, 成都 610000;
    3. 教育部动物抗病营养研究重点实验室, 成都 611130
柏雪(1985-),女,四川广安人,博士研究生,从事饲料及畜产品安全研究。E-mail:287190724@qq.com

收稿日期: 2016-09-12

  网络出版日期: 2017-03-09

基金资助

国家自然科学基金青年项目(31402031);四川省教育厅青年基金(13ZB0290);科技部支撑计划(2014BAD13B04);四川省科技厅项目(2014NZ0043,2014NZ0002,2013NZ0054)

Advances in Lack of Amino Acid-Mediated Autophagy via Mammalian Target of Rapamycin Complex 1 Signal Pathway

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  • 1. Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China;
    2. College of Life Science and Technology, Southwest University for Nationalities, Chengdu 610000, China;
    3. Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu 611130, China

Received date: 2016-09-12

  Online published: 2017-03-09

摘要

自噬是机体维持自身稳态的一种重要生理活动,当体内氨基酸或葡萄糖等营养缺乏时,细胞会启动自噬。自噬受到多种信号通路的调节,哺乳动物雷帕霉素靶蛋白复合体C1(mTORC1)信号通路是其中重要的一条,它可以使自噬相关基因13(Atg13)磷酸化,抑制自噬起始。本文将围绕近年来报道的氨基酸缺乏诱导细胞自噬的mTORC1信号通路,包括小G蛋白、腺苷酸活化蛋白激酶(AMPK)、微小RNA(miRNA)、氨基酰-tRNA合成酶在其中的作用等研究进展进行综述。

关键词: 氨基酸; 自噬; mTORC1; 机制

本文引用格式

柏雪, 王建萍, 丁雪梅, 白世平, 曾秋凤, 张克英 . 氨基酸缺乏诱导细胞自噬的哺乳动物雷帕霉素靶蛋白复合体C1信号通路机制研究进展[J]. 动物营养学报, 2017 , 29(3) : 749 -754 . DOI: 10.3969/j.issn.1006-267x.2017.03.003

Abstract

Autophagy is an important physiological activity for keeping organism steady. Cell will active the autophagy when the nutrient as amino acid and glucose deficiency. The autophagy is regulated by many signal pathways, and mammalian target of rapamycin complex 1 (mTORC1) is one of the important pathway, it can make autophagy factor autophagy-related gene 13 (Atg13) phosphorylation to inhibit autophagy starting. In this review, we summarized the results and conclusions from recent works on amino acid-mediated autophagy via the mTORC1 signal pathway including small G protein, adenosine 5 monophosphate-activated protein kinase(AMPK), microRNA(miRNA), aminoacyl-tRNA synthetase.

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