[1] 戎芬.出生体重与环境因素对儿童青少年超重肥胖影响的队列研究[D].博士学位论文.上海:复旦大学,2012.
[2] KWON J M,GOATE A M.The candidate gene approach[J].Alcohol Research and Health,2000,24(3):164-168.
[3] KLEIN R J,ZEISS C,CHEW E Y,et al.Complement factor H polymorphism in age-related macular degeneration[J].Science,2005,308(5720):385-389.
[4] HERBERT A,GERRY N P,MCQUEEN M B,et al.A common genetic variant is associated with adult and childhood obesity[J].Science,2006,312(5771):279-283.
[5] SAXENA R,VOIGHT B F,LYSSENKO V,et al.Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels[J].Science,2007,316(5829):1331-1336.
[6] VAN DER HOEVEN F,SCHIMMANG T,VOLKMANN A,et al.Programmed cell death is affected in the novel mouse mutant Fused toes (Ft)[J].Development,1994,120(9):2601-2607.
[7] ANSELME I,LACLEF C,LANAUD M,et al.Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes[J].Developmental Biology,2007,304(1):208-220.
[8] PETERS T,SERTH K, RVTHER U.Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation[J].Mammalian Genome,1999,10(10):983-986.
[9] FRAYLING T M,TIMPSON N J,WEEDON M N,et al.A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity[J].Science,2007,316(5826):889-894.
[10] ROBBENS S,ROUZÉ P,COCK J M,et al.The FTO gene,implicated in human obesity,is found only in vertebrates and marine algae[J].Journal of Molecular Evolution,2008,66(1):80-84.
[11] OLSZEWSKI P K,FREDRIKSSON R,OLSZEWSKA A M,et al.Hypothalamic FTO is associated with the regulation of energy intake not feeding reward[J].BMC neuroscience,2009,10(1):129.
[12] STRATIGOPOULOS G,PADILLA S L,LEDUC C A,et al.Regulation of FTO/FTM gene expression in mice and humans[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,2008,294(4):R1185-R1196.
[13] JIA G F,YANG C G,YANG S D,et al.Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO[J].FEBS letters,2008,582(23/24):3313-3319.
[14] ZHENG G Q,FU Y,HE C.Nucleic acid oxidation in DNA damage repair and epigenetics[J].Chemical Reviews,2014,114(8):4602-4620.
[15] GERKEN T,GIRARD C A,TUNG Y C L,et al.The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase[J].Science,2007,318(5855):1469-1472.
[16] TIWARI A,KRZYSIK-WALKER S M,RAMACHANDRAN R.Cloning and characterization of chicken fat mass and obesity associated (Fto) gene:fasting affects Fto expression[J].Domestic Animal Endocrinology,2012,42(1):1-10.
[17] HAN Z F,NIU T H,CHANG J B,et al.Crystal structure of the FTO protein reveals basis for its substrate specificity[J].Nature,2010,464(7292):1205-1209.
[18] MADSEN M B,BIRCK M M,FREDHOLM M,et al.Expression studies of the obesity candidate gene FTO in pig[J].Animal Biotechnology,2009,21(1):51-63.
[19] 付言峰,李兰,王学敏,等.苏钟猪FTO基因的mRNA表达、克隆测序及其生物信息学分析[J].华北农学报,2013,28(1):128-134.
[20] DINA C,MEYRE D,GALLINA S,et al.Variation in FTO contributes to childhood obesity and severe adult obesity[J].Nature Genetics,2007,39(6):724-726.
[21] GONZÁLEZ-SÁNCHEZ J L,ZABENA C,MARTÍNEZ-LARRAD M T,et al.Variant rs9939609 in the FTO gene is associated with obesity in an adult population from Spain[J].Clinical Endocrinology,2009,70(3):390-393.
[22] CHA S W,CHOI S M,KIM K S,et al.Replication of genetic effects of FTO polymorphisms on BMI in a Korean population[J].Obesity,2008,16(9):2187-2189.
[23] HOTTA K,NAKATA Y,MATSUO T,et al.Variations in the FTO gene are associated with severe obesity in the Japanese[J].Journal of Human Genetics,2008,53(6):546-553.
[24] DO R,BAILEY S D,DESBIENS K,et al.Genetic variants of FTO influence adiposity,insulin sensitivity,leptin levels,and resting metabolic rate in the Quebec family study[J].Diabetes,2008,57(4):1147-1150.
[25] GRANT S F,LI M,BRADFIELD J P,et al.Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP[J].PLoS One,2008,3(3):e1746.
[26] SPEAKMAN J R,RANCE K A,JOHNSTONE A M.Polymorphisms of the FTO gene are associated with variation in energy intake,but not energy expenditure[J].Obesity,2008,16(8):1961-1965.
[27] HAUPT A,THAMER C,STAIGER H,et al.Variation in the FTO gene influences food intake but not energy expenditure[J].Experimental and Clinical Endocrinology & Diabetes:Official Journal,2009,117(4):194-197.
[28] CECIL J E,TAVENDALE R,WATT P,et al.An obesity-associated FTO gene variant and increased energy intake in children[J].The New England Journal of Medicine,2009,359(24):2558-2566.
[29] WARDLE J,CARNELL S,HAWORTH C M A,et al.Obesity associated genetic variation in FTO is associated with diminished satiety[J].The Journal of Clinical Endocrinology & Metabolis,2008,93(9):3640-3643.
[30] KARRA E,O'DALY O G,CHOUDHURY A I,et al.A link between FTO,ghrelin,and impaired brain food-cue responsivity[J].The Journal of Clinical Investigation,2013,123(8):3539-3551.
[31] CLARK J T,KALRA P S,CROWLEY W R,et al.Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats[J].Endocrinology,1984,115(1):427-429.
[32] WREN A M,SEAL L J,COHEN M E,et al.Ghrelin enhances appetite and increases food intake in humans[J].The Journal of Clinical Endocrinology & Metabolism,2001,86(12):5992.
[33] MORTON G,SCHWARTZ M.The NPY/AgRP neuron and energy homeostasis[J].International Journal of Obesity and Related Metabolic Disorder,2001,25(Suppl.5):S56-S62.
[34] GIBBS J,YOUNG R C,SMITH G P.Cholecystokinin decreases food intake in rats[J].Journal of Comparative and Physiological Psychology,1973,84(3):488-495.
[35] AHIMA R S,PRABAKARAN D,MANTZOROS C,et al.Role of leptin in the neuroendocrine response to fasting[J].Nature,1996,382(6588):250-252.
[36] SAHU A.Evidence suggesting that galanin (GAL),melanin-concentrating hormone (MCH),neurotensin (NT),proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus[J].Endocrinology,1998,139(2):795-798.
[37] KOJIMA M,HOSODA H,DATE Y,et al.Ghrelin is a growth-hormone-releasing acylated peptide from stomach[J].Nature,1999,402(6762):656-660.
[38] BENEDICT C,AXELSSON T,SÖDERBERG S,et al.Fat mass and obesity-associated gene (FTO) is linked to higher plasma levels of the hunger hormone ghrelin and lower serum levels of the satiety hormone leptin in older adults[J].Diabetes,2014,63(11):3955-3959.
[39] QI L,KANG K,ZHANG C L,et al.Fat Mass-and obesity-associated (FTO) gene variant is associated with obesity:longitudinal analyses in two cohort studies and functional test[J].Diabetes,2008,57(11):3145-3151.
[40] LABAYEN I,RUIZ J R,ORTEGA F B,et al.Association between the FTO rs9939609 polymorphism and leptin in European adolescents:a possible link with energy balance control.The HELENA study[J].International Journal of Obesity,2011,35(1):66-71.
[41] ARRIZABALAGA M,LARRARTE E,MARGARETO J,et al.Preliminary findings on the influence of FTO rs9939609 and MC4R rs17782313 polymorphisms on resting energy expenditure,leptin and thyrotropin levels in obese non-morbid premenopausal women[J].Journal of Physiology and Biochemistry,2014,70(1):255-262.
京公网安备 11010802041926号