综述 Review

绿原酸的生物活性及其作用机制

展开
  • 1. 湖南师范大学生命科学学院, 动物营养与人体健康实验室, 长沙 410006;
    2. 中国科学院亚热带农业生态研究所, 畜禽养殖污染控制与资源化技术国家工程实验室, 中国科学院亚热带农业生态过程重点实验室, 长沙 410125;
    3. 中国科学院大学研究生院, 北京 100049;
    4. 湖南畜禽安全生产协同创新中心, 长沙 410128
王文龙(1989—),男,河南平顶山人,博士研究生,从事动物营养与生理生化研究。E-mail:wangwenlong2012@yeah.net

收稿日期: 2016-12-14

  网络出版日期: 2017-07-05

基金资助

湖南省重大专项(2015NK1002);湖南省重点研发计划(2016NK2170);湖南省自然科学基金面上项目(S2014J504I);中国科学院青年创新促进会项目(2016326);湖南省研究生科研创新项目(CX2017B183)

Biological Properties of Chlorogenic Acid and Its Mechanism of Action

Expand
  • 1. Laboratory of Animal Nutrition and Human Health, School of Life Sciences, Hunan Normal University, Changsha 410006, China;
    2. Key Laboratory of Agro-Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Science, Changsha 410125, China;
    3. University of Chinese Academy of Science, Beijing 100049, China;
    4. Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China

Received date: 2016-12-14

  Online published: 2017-07-05

摘要

绿原酸(CGA)是一种广泛存在的多酚类物质,具有抗氧化、抗炎、抗菌和降糖降脂等多种生物学功能,在动物生产和人体健康领域具有广阔的应用前景。本文简要综述了CGA的来源与分布、理化性质、生物活性及其主要作用机制,为CGA的深入研究和进一步开发应用提供参考依据。

本文引用格式

王文龙, 文超越, 郭秋平, 段叶辉, 李颖慧, 何善平, 李凤娜 . 绿原酸的生物活性及其作用机制[J]. 动物营养学报, 2017 , 29(7) : 2220 -2227 . DOI: 10.3969/j.issn.1006-267x.2017.07.002

Abstract

Chlorogenic acid (CGA), as one of the most abundant polyphenol compounds, is widely distributed in nature. Its biological properties include antioxidant, anti-inflammatory, antibacterial, hypoglycemic, hypolipidemic activities and so on, which make it have broad scope in applications in the fields of animal production and human health care. This paper briefly summarized the source, distribution, physicochemical characters, biological properties of CGA and its mechanism of action, in order to provide a reference for further research and exploitation.

参考文献

[1] PCHELKIN V P.Natural phenolic and lipophilic complexes of chlorogenic acid[J].Pharmaceutical Chemistry Journal,2003,37(1):25-27.  

[2] BASSOLI B K,CASSOLLA P,BORBA-MURAD G R,et al.Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test:effects on hepatic glucose release and glycaemia[J].Cell Biochemistry and Function,2008,26(3):320-328.  

[3] DOS SANTOS M D,ALMEIDA M C,LOPES N P,et al.Evaluation of the anti-inflammatory,analgesic and antipyretic activities of the natural polyphenol chlorogenic acid[J].Biological and Pharmaceutical Bulletin,2006,29(11):2236-2240.  

[4] DE SOTILLO D V R,HADLEY M,SOTILLO J E.Insulin receptor exon 11+/- is expressed in Zucker (fa/fa) rats,and chlorogenic acid modifies their plasma insulin and liver protein and DNA[J].The Journal of Nutritional Biochemistry,2006,17(1):63-71.  

[5] NICASIO P,AGUILAR-SANTAMARÍA L,ARANDA E,et al.Hypoglycemic effect and chlorogenic acid content in two Cecropia species[J].Phytotherapy Research,2005,19(8):661-664.  

[6] DAAYF F,LATTANZIO V.Recent advances in polyphenol research Vol.1[M].New Jersey:Wiley-Blackwell,2009:311-351.

[7] KIMURA Y,OKUDA H,OKUDA T,et al.Studies on the activities of tannins and related compounds from medicinal plants and drugs.Ⅶ.Effects of extracts of leaves of Artemisia species,and caffeic acid and chlorogenic acid on lipid metabolic injury in rats fed peroxidized oil[J].Chemical and Pharmaceutical Bulletin,1985,33(5):2028-2034.  

[8] 周荣汉.中药资源学[M].北京:中国医药科技出版社,1993:240.

[9] MATTILA P,HELLSTRÖM J.Phenolic acids in potatoes,vegetables,and some of their products[J].Journal of Food Composition and Analysis,2007,20(3/4):152-160.

[10] 周志娥,罗秋水,熊建华,等.绿原酸、异绿原酸A对大肠杆菌的抑菌机制[J].食品科技,2014,39(3):228-232.

[11] 李淑媛,常翠青.氯原酸的生物活性与人体健康[J].卫生研究,2005,34(6):762-764.

[12] CLIFFORD M N.Chlorogenic acids and other cinnamates-nature,occurrence,dietary burden,absorption and metabolism[J].Journal of the Science of Food and Agriculture,2000,80(7):1033-1043.  

[13] DORRELL D G.Chlorogenic acid content of meal from cultivated and wild sunflowers[J].Crop Science,1976,16(3):422-424.  

[14] 宁正祥.食品生物化学[M].2版.广州:华南理工大学出版社,2006:356.

[15] JI L L,JIANG P,LU B,et al.Chlorogenic acid,a dietary polyphenol,protects acetaminophen-induced liver injury and its mechanism[J].The Journal of Nutritional Biochemistry,2013,24(11):1911-1919.  

[16] FENG R T,LU Y J,BOWMAN L L,et al.Inhibition of activator protein-1,NF-κB,and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid[J].Journal of Biological Chemistry,2005,280(30):27888-27895.  

[17] 李文娜,肖苑,陈阳,等.杜仲叶绿原酸提取物与绿原酸、维生素C体外抗氧化比较[J].食品工业科技,2012,33(11):137-140.

[18] BOETTLER U,VOLZ N,PAHLKE G,et al.Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase Ⅱ-enzymes via the Nrf2/ARE pathway in vitro and in vivo[J].Molecular Nutrition & Food Research,2011,55(5):798-802.  

[19] LOU L X,ZHOU J W,LIU Y J,et al.Chlorogenic acid induces apoptosis to inhibit inflammatory proliferation of IL-6-induced fibroblast-like synoviocytes through modulating the activation of JAK/STAT and NF-κB signaling pathways[J].Experimental and Therapeutic Medicine,2016,11(5):2054-2060.

[20] LAWRENCE T.The nuclear factor NF-κB pathway in inflammation[J].Cold Spring Harbor Perspectives in Biology,2009,1(6):a001651.

[21] SHAN J H,FU J,ZHAO Z H,et al.Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-κB and JNK/AP-1 activation[J].International Immunopharmacology,2009,9(9):1042-1048.  

[22] HWANG S J,KIM Y W,PARK Y,et al.Anti-inflammatory effects of chlorogenic acid in lipopolysaccharide-stimulated RAW 264.7 cells[J].Inflammation Research,2014,63(1):81-90.  

[23] YOON T,CHEON M S,LEE A Y,et al.Anti-inflammatory activity of methylene chloride fraction from Glehnia littoralis extract via suppression of NF-κB and mitogen-activated protein kinase activity[J].Journal of Pharmacological Sciences,2010,112(1):46-55.  

[24] MITJAVILA M T,MORENO J J.The effects of polyphenols on oxidative stress and the arachidonic acid cascade.Implications for the prevention/treatment of high prevalence diseases[J].Biochemical Pharmacology,2012,84(9):1113-1122.  

[25] SHI H T,DONG L,JIANG J,et al.Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway[J].Toxicology,2013,303:107-114.

[26] GAO R F,FU Y H,WEI Z K,et al.Chlorogenic acid attenuates lipopolysaccharide-induced mice mastitis by suppressing TLR4-mediated NF-κB signaling pathway[J].European Journal of Pharmacology,2014,729:54-58.

[27] GUO Y J,LUO T,WU F,et al.Involvement of TLR2 and TLR9 in the anti-inflammatory effects of chlorogenic acid in HSV-1-infected microglia[J].Life Sciences,2015,127:12-18.

[28] ZHENG Z Y,SHENG Y C,LU B,et al.The therapeutic detoxification of chlorogenic acid against acetaminophen-induced liver injury by ameliorating hepatic inflammation[J].Chemico-Biological Interactions,2015,238:93-101.

[29] ZHU X F,ZHANG H X,LO R.Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities[J].Journal of Agricultural and Food Chemistry,2004,52(24):7272-7278.  

[30] KONO Y,KOBAYASHI K,TAGAWA S,et al.Antioxidant activity of polyphenolics in diets:rate constants of reactions of chlorogenic acid and caffeic acid with reactive species of oxygen and nitrogen[J].Biochimica et Biophysica Acta:General Subjects,1997,1335(3):335-342.  

[31] LO H H,CHUNG J G.The effects of plant phenolics,caffeic acid,chlorogenic acid and ferulic acid on arylamine N-acetyltransferase activities in human gastrointestinal microflora[J].Anticancer Research,1999,19(1A):133-139.

[32] 罗艺晨,黄利明,杨颖,等.绿原酸抑制金黄色葡萄球菌机理研究[J].西南大学学报:自然科学版,2016,38(3):15-19.

[33] FRANCISCO V,COSTA G,FIGUEIRINHA A,et al.Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-κB pathway inhibition:contribution of chlorogenic acid[J].Journal of Ethnopharmacology,2013,148(1):126-134.  

[34] LOU Z X,WANG H X,ZHU S,et al.Antibacterial activity and mechanism of action of chlorogenic acid[J].Journal of Food Science,2011,76(6):M398-M403.

[35] REN S,WU M,GUO J Y,et al.Sterilization of polydimethylsiloxane surface with Chinese herb extract:a new antibiotic mechanism of chlorogenic acid[J].Scientific Reports,2015,5:10464.

[36] OJHA D,MUKHERJEE H,GHOSH S,et al.Evaluation of anti-infective potential of a tribal folklore Odina wodier Roxb against some selected microbes and herpes simplex virus associated with skin infection[J].Journal of Applied Microbiology,2013,115(6):1317-1328.  

[37] 潘曌曌,王雪峰,闫丽娟,等.金银花提取物体外抗甲型流感病毒FM1株的研究[J].中国中医药信息杂志,2007,14(6):37-38,51.

[38] 王学兵,崔保安,魏战勇,等.绿原酸对猪繁殖与呼吸综合征病毒体外作用的研究[J].中国农业科技导报,2008,10(3):107-110.

[39] 王学兵,魏战勇,崔保安,等.绿原酸的提取及其对猪细小病毒的体外作用研究[J].中国畜牧兽医,2008,35(12):123-125.

[40] 相婷,吴立军,董梅,等.西南忍冬化学成分的研究(Ⅰ)[J].中国药物化学杂志,1998,8(1):44-45,48.

[41] SCHINDLER P W,BELOW P,HEMMERLE H,et al.Identification of two new inhibitors of the hepatic glucose-6-phosphatase system[J].Drug Development Research,1998,44(1):34-40.  

[42] 邱阳阳.咖啡碱和绿原酸对小鼠和3T3-L1细胞脂肪代谢的影响[D].硕士学位论文.南昌:江西农业大学,2013:43-56.

[43] 吴铁梅,闫素梅,格日乐玛.脂肪细胞因子对动物脂类代谢的调控机理[J].动物营养学报,2016,28(10):3034-3041.

[44] ONG K W,HSU A,TAN B K H.Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation[J].Biochemical Pharmacology,2013,85(9):1341-1351.  

[45] ZHENG G D,QIU Y Y,ZHANG Q F,et al.Chlorogenic acid and caffeine in combination inhibit fat accumulation by regulating hepatic lipid metabolism-related enzymes in mice[J].British Journal of Nutrition,2014,112(6):1034-1040.  

[46] BIRARI R B,BHUTANI K K.Pancreatic lipase inhibitors from natural sources:unexplored potential[J].Drug Discovery Today,2007,12(19/20):879-889.

[47] DE LA GARZA A L,MILAGRO F I,BOQUE N,et al.Natural inhibitors of pancreatic lipase as new players in obesity treatment[J].Planta Medica,2011,77(8):773-785.  

[48] JOHNSTON K L,CLIFFORD M N,MORGAN L M.Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans:glycemic effects of chlorogenic acid and caffeine[J].The American Journal of Clinical Nutrition,2003,78(4):728-733.

[49] JUNG U J,LEE M K,PARK Y B,et al.Antihyperglycemic and antioxidant properties of caffeic acid in db/db mice[J].Journal of Pharmacology and Experimental Therapeutics,2006,318(2):476-483.  

[50] ONG K W,HSU A,TAN B K H.Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation:a contributor to the beneficial effects of coffee on diabetes[J].PLoS One,2012,7(3):e32718.

[51] 刘英,王之盛,周安国.橙皮苷、绿原酸对断奶仔猪生长、抗氧化和免疫机能的影响[J].中国兽医学报,2009,29(9):1233-1236.

[52] 黄少文,魏金涛,赵娜,等.绿原酸和维生素E对母猪繁殖和抗氧化性能的影响[J].中国畜牧杂志,2015,51(24):79-83.

[53] 周艳.杜仲叶多酚提取物对猪肉品质及绿原酸缓解肝-肠损伤研究[D].博士学位论文.南昌:南昌大学,2015:17-34.

[54] RUAN Z,LIU S Q,ZHOU Y,et al.Chlorogenic acid decreases intestinal permeability and increases expression of intestinal tight junction proteins in weaned rats challenged with LPS[J].PLoS One,2014,9(6):e97815.

[55] 陈玉敏,黄涛,宋小珍,等.饲粮中添加杜仲叶提取物对爱拔益加肉鸡生长性能及免疫功能的影响[J].动物营养学报,2015,27(7):2224-2230.

[56] 李乃顺,冷向军,李小勤,等.绿原酸对草鱼鱼种生长、非特异性免疫和肉质的影响[J].水生生物学报,2014,38(4):619-626.

[57] 温安祥,舒辉,肖洋.绿原酸对中华鳖生产性能及抗氧化能力的影响[J].动物营养学报,2010,22(3):729-733.

[58] LIANG N J,KITTS D D.Role of chlorogenic acids in controlling oxidative and inflammatory stress conditions[J].Nutrients,2015,8(1):16.
文章导航

/