综述 Review

乳及乳制品中黄曲霉毒素M1研究进展

展开
  • 1. 中国农业科学院北京畜牧兽医研究所, 动物营养学国家重点实验室, 北京 100193;
    2. 农业部奶及奶制品质量 监督检验测试中心(北京), 北京 100193;
    3. 农业部奶产品质量安全风险评估实验室(北京), 北京 100193
高亚男(1992—),女,山东威海人,博士研究生,动物营养与饲料科学专业。E-mail:gyn758521@126.com

收稿日期: 2016-12-19

  网络出版日期: 2017-07-05

基金资助

现代农业产业技术体系专项资金(nycytx-04-01);中国农业科学院科技创新工程(ASTIP-IAS12);国家自然科学基金资助项目(31501399)

Aflatoxin M1 in Milk and Dairy Products: A Review

Expand
  • 1. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    2. Ministry of Agriculture-Milk and Dairy Product Inspection Center, Beijing 100193, China;
    3. Ministry of Agriculture-Milk Risk Assessment Laboratory, Beijing 100193, China

Received date: 2016-12-19

  Online published: 2017-07-05

摘要

随着我国经济的发展与人们生活水平的提高,具有丰富营养价值的乳及乳制品逐渐成为人们日常生活的必需消费品。与此同时,人们对乳及乳制品的期待不再局限于量的提高,而是对其质量和安全提出了更高的要求。由于2011年发生的牛奶中黄曲霉毒素M1(AFM1)含量超标事件,以及相比于成人,婴幼儿更易受到牛奶中AFM1的损害,人们开始更加重视乳及乳制品中存在的AFM1污染问题。本文在国内外已有文献报道基础上,对乳及乳制品中AFM1的来源与生物学性质、污染与限量标准、检测与防控技术进行综述。

本文引用格式

高亚男, 王加启, 郑楠 . 乳及乳制品中黄曲霉毒素M1研究进展[J]. 动物营养学报, 2017 , 29(7) : 2228 -2236 . DOI: 10.3969/j.issn.1006-267x.2017.07.003

Abstract

With economic development and improvement of people's living standards in China, milk and dairy products, with rich nutritional value, have gradually become the people's daily necessities of life. At the same time, people become more attractive with the quality of milk and dairy products instead of the quantity. As a result of the occurrence of aflatoxin M1 (AFM1) in milk of a certain brand in 2011, and the fact that infants and young children are more vulnerable to AFM1 compared with adults, more attention has been paid to concerning the AFM1 pollution problems in milk and dairy products. This review summarized the origin and biological properties, pollution and limit regulations, detection and prevention technologies of AFM1 in milk and dairy products, based on the previous studies.

参考文献

[1] PRANDINI A,TANSINI G,SIGOLO S,et al.On the occurrence of aflatoxin M1 in milk and dairy products[J].Food Chemical Toxicology,2009,47(5):984-991.  

[2] 王蕾.牛奶中黄曲霉毒素M1检测方法的建立及饲料中黄曲霉毒素对牛奶品质的影响[D].硕士学位论文.郑州:河南农业大学,2008.

[3] FALLAH A A.Aflatoxin M1 contamination in dairy products marketed in Iran during winter and summer[J].Food Control,2010,21(11):1478-1481.  

[4] FALLAH A A.Assessment of aflatoxin M1 contamination in pasteurized and UHT milk marketed in central part of Iran[J].Food Chemical Toxicology,2010,48(3):988-991.  

[5] IQBAL S Z,PATERSON R R M,BHATTI I A,et al.Survey of aflatoxins in chillies from Pakistan produced in rural,semi-rural and urban environments[J].Food Additives & Contaminants:Part B,2010,3(4):268-274.  

[6] BOUDRA H,BARNOUIN J,DRAGACCI S,et al.Aflatoxin M1 and ochratoxin A in raw bulk milk from French dairy herds[J].Journal of Dairy Science,2007,90(7):3197-3201.  

[7] LANCASTER M C,JENKINS F P,PHILP J M.Toxicity ass ociated with certain samples of groundn uts[J].Nature,1961,192(4807):1095-1096.  

[8] ALLCROFT R,CARNAGHAN R B A.Groundnut toxicity:an examination for toxin in human food products from animals fed toxic groundnut meal[J].Veterinary Record,1963,75:259-263.

[9] WANG H F,DICK R,YIN H Q,et al.Structure-function relationships of human liver cytochromes P450 3A:aflatoxin B1 metabolism as a probe[J].Biochemistry,1998,37(36):12536-12545.  

[10] OVEISI M R,JANNAT B,SADEGHI N,et al.Presence of aflatoxin M1 in milk and infant milk products in Tehran,Iran[J].Food Control,2007,18(10):1216-1218.  

[11] 聂晶,刘兴玠.黄曲霉毒素M1研究进展[J].国外医学:卫生学分册,1992(3):159-161.

[12] RASTOGI S,DWIVEDI P D,KHANNA S K,et al.Detection of aflatoxin M1 contamination in milk and infant milk products from Indian markets by ELISA[J].Food Control,2004,15(4):287-290.  

[13] GALVANO F,GALOFARO V,RITIENI A,et al.Survey of the occurrence of aflatoxin M1 in dairy products marketed in Italy:second year of observation[J].Food Additives & Contaminants,2001,18(7):644-646.  

[14] SZAKÁCS G,VÁRADI A,ÖZVEGY-LACZKA C,et al.The role of ABC transporters in drug absorption,distribution,metabolism,excretion and toxicity (ADME-Tox)[J].Drug Discovery Today,2008,13(9/10):379-393.

[15] SHYU R H,SHYU H F,LIU H W,et al.Colloidal gold-based immunochromatographic assay for detection of ricin[J].Toxicon,2002,40(3):255-258.  

[16] SUN X L,ZHAO X L,TANG J,et al.Development of an immunochromatographic assay for detection of aflatoxin B1 in foods[J].Food Control,2006,17(4):256-262.  

[17] IARC.IARC monographs on the evaluation of cancinogenic risk to humans[M].Lyon:World Health Oranisation,2002:53-64.

[18] IARC.IARC monographs on the evaluation of carcinogenic risk to humans[M].Lyon:World Health Organization,1993:56.

[19] LUTZ W,JAGGI W,LVTHY J,et al.In vivo covalent binding of aflatoxin B1 and aflatoxin M1 to liver DNA of rat,mouse and pig[J].Chemico-Biological Interactions,1980,32(3):249-256.  

[20] 孙兴荣.黄曲霉毒素M1免疫亲和层析柱的研制[D].硕士学位论文.大庆:黑龙江八一农垦大学,2011.

[21] 杨其名.泔水猪肝脏、肾脏和瘦肉中黄曲霉毒素B1、M1含量的检测[D].硕士学位论文.兰州:甘肃农业大学,2004.

[22] 孙桂菊,钱耕荪,金锡鹏,等.肝癌高发地区人群黄曲霉毒素暴露水平的评估[J].东南大学学报:医学版,2002,21(1):118-122.

[23] 钱耕荪.黄曲霉毒素与人肝癌关系的最新研究进展[J].中国肿瘤,2002,11(11):633-636.

[24] TSAKIRIS I N,TZATZARAKIS M N,ALEGAKIS A K,et al.Risk assessment scenarios of children's exposure to aflatoxin M1 residues in different milk types from the Greek market[J].Food and Chemical Toxicology,2013,56:261-265.

[25] SANTINI A,RAIOLA A,FERRANTELLI V,et al.Aflatoxin M1 in raw,UHT milk and dairy products in Sicily (Italy)[J].Food Additives & Contaminants:Part B,2013,6(3):181-186.  

[26] EL-TRAS W F,EL-KADY N N,TAYEL A A.Infants exposure to aflatoxin M1 as a novel foodborne zoonosis[J].Food and Chemical Toxicology,2011,49(11):2816-2819.  

[27] ELZUPIR A O,ELHUSSEIN A M.Determination of aflatoxin M1 in dairy cattle milk in Khartoum State,Sudan[J].Food Control,2010,21(6):945-946.  

[28] ALONSO V A,MONGE M P,LARRIESTRA A,et al.Naturally occurring aflatoxin M1 in raw bulk milk from farm cooling tanks in Argentina[J].Food Additives & Contaminants:Part A,2010,27(3):373-379.  

[29] IHA M H,BARBOSA C B,OKADA I A,et al.Aflatoxin M1 in milk and distribution and stability of aflatoxin M1 during production and storage of yoghurt and cheese[J].Food Control,2013,29(1):1-6.  

[30] HAN R W,ZHENG N,WANG J Q,et al.Survey of aflatoxin in dairy cow feed and raw milk in China[J].Food Control,2013,34(1):35-39.  

[31] XIONG J L,WANG Y M,MA M R,et al.Seasonal variation of aflatoxin M1 in raw milk from the Yangtze River Delta region of China[J].Food Control,2013,34(2):703-706.  

[32] GUO L Y,ZHENG N,ZHANG Y D,et al.A survey of seasonal variations of aflatoxin M1 in raw milk in Tangshan region of China during 2012-2014[J].Food Control,2016,69:30-35.

[33] ASI M R,IQBAL S Z,ARIÑO A,et al.Effect of seasonal variations and lactation times on aflatoxin M1 contamination in milk of different species from Punjab,Pakistan[J].Food Control,2012,25(1):34-38.  

[34] GOLGE O.A survey on the occurrence of aflatoxin M1 in raw milk produced in Adana province of Turkey[J].Food Control,2014,45:150-155.

[35] KRBI? B,?IVAN?EV J,ANTI? I,et al.Levels of aflatoxin M1 in different types of milk collected in Serbia:assessment of human and animal exposure[J].Food Control,2014,40:113-119.

[36] 黄良策,郑楠,韩荣伟,等.牛奶中黄曲霉毒素M1检测方法研究进展[J].分析与检测2012(3):39-41.

[37] FALLAH A A,RAHNAMA M,JAFARI T,et al.Seasonal variation of aflatoxin M1 contamination in industrial and traditional Iranian dairy products[J].Food Control,2011,22(10):1653-1656.  

[38] CHIAVARO E,CACCHIOLI C,BERNI E,et al.Immunoaffinity clean-up and direct fluorescence measurement of aflatoxins B1 and M1 in pig liver:comparison with high-performance liquid chromatography determination[J].Food Additives & Contaminants,2005,22(11):1154-1161.  

[39] 中华人民共和国卫生部.GB 5413.37—2010食品安全国家标准 乳和乳制品中黄曲霉毒素M1的测定[S].北京:中国标准出版社,2010.

[40] 丁俭,李培武,李光明,等.在线固相萃取富集-高效液相色谱法快速测定牛奶中黄曲霉毒素 M1[J].食品科学,2013,34(10):289-293.

[41] 董彬,杨立新,李斌,等.多功能柱净化液相色谱-质谱-质谱法测定牛奶中黄曲霉毒素M1[J].现代农药,2011,10(4):38-40.

[42] ANFOSSI L,BAGGIANI C,GIOVANNOLI C,et al.Occurrence of aflatoxin M1 in Italian cheese:results of a survey conducted in 2010 and correlation with manufacturing,production season,milking animals,and maturation of cheese[J].Food Control,2012,25(1):125-130.  

[43] WANG J J,LIU B H,HSU Y T,et al.Sensitive competitive direct enzyme-linked immunosorbent assay and gold nanoparticle immunochromatographic strip for detecting aflatoxin M1 in milk[J].Food Control,2011,22(6):964-969.  

[44] 李鹏,王文杰.饲料中常见的霉菌毒素及防制[J].饲料研究,2009(4):13-17.

[45] 姜淼,邬本成,王改琴,等.物理过筛对玉米中霉菌毒素的去除效果[J].饲料工业,2013,34(6):45-48.

[46] 房祥军,邹晓庭.饲料霉菌毒素污染的危害及其防治[J].中国饲料,2006(11):34-37.

[47] 纪少丽,MOORE D,金立志.牛奶中黄曲霉毒素的残留与控制措施[J].中国奶牛,2012(24):36-40.

[48] 田维荣,代兴红,胡萍.牛奶中黄曲霉毒素的危害及质量控制[J].畜牧与饲料科学,2013,34(2):36-38.

[49] PHILLIPS T D,KUBENA L F,HARVEY R B,et al.Mycotoxin hazards in agriculture:new approach to control[J].Journal of the American Veterinary Medical Association,1987,12:1617.

[50] KUTZ R E,SAMPSON J D,POMPEU L B,et al.Efficacy of solis,novasil plus,and MTB-100 to reduce aflatoxin M1 levels in milk of early to mid lactation dairy cows fed aflatoxin B1[J].Journal of Dairy Science,2009,92(8):3959-3963.  

[51] DIAZ D E,HAGLER W M,Jr,BLACKWELDER J T,et al.Aflatoxin bindersⅡ:reduction of aflatoxin M1 in milk by sequestering agents oof cows consuming aflatoxin in feed[J].Mycopathologia,2004,157(2):233-241.  

[52] FIRMIN S,MORGAVI D P,YIANNIKOURIS A,et al.Effectiveness of modified yeast cell wall extracts to reduce aflatoxin B1 absorption in dairy ewes[J].Journal of Dairy Science,2011,94(11):5611-5619.  

[53] QUEIROZ O C M,HAN J H,STAPLES C R,et al.Effect of adding a mycotoxin-sequestering agent on milk aflatoxin M1 concentration and the performance and immune response of dairy cattle fed an aflatoxin B1-contaminated diet[J].Journal of Dairy Science,2012,95(10):5901-5908.  

[54] EL KHOURY A,ATOUI A,YAGHI J.Analysis of aflatoxin M1 in milk and yogurt and AFM1 reduction by lactic acid bacteria used in Lebanese industry[J].Food Control,2011,22(10):1695-1699.  

[55] ELSANHOTY R M,SALAM S A,RAMADAN M F,et al.Detoxification of aflatoxin M1 in yoghurt using probiotics and lactic acid bacteria[J].Food Control,2014,43:129-134
文章导航

/