综述 Review

转化生长因子β1/Smads信号传导通路在哺乳动物卵巢发育中的调控作用及其作用机制

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  • 1. 山东农业大学动物科技学院, 山东省动物生物工程与疾病防治重点实验室, 泰安 271018;
    2. 泰安市中心医院, 泰安 271000
周敏(1993—),女,山东淄博人,硕士研究生,动物营养与饲料科学专业。E-mail:1654233314@qq.com

收稿日期: 2017-01-15

  网络出版日期: 2017-07-05

基金资助

国家自然科学基金项目(31572441);山东省现代农业产业技术体系生猪创新团队建设项目(SDAIT-08-04);“双一流”奖补资金资助(FundsofShandong“DoubleTops”Program)

Regulation and Mechanism of Transforming Growth Factor-β1/Smads Signaling Pathway on Development of Ovaries in Mammalian

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  • 1. Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China;
    2. Tai'an Central Hospital, Tai'an 271000, China

Received date: 2017-01-15

  Online published: 2017-07-05

摘要

不同信号转导通路间的彼此协调保证了机体的正常运行。在众多的信号通路中,转化生长因子(TGF)β1/Smads信号传导通路越来越受到学者们的关注,已经成为分子生物学和细胞生物学研究的一大热点。已有研究证实,TGF-β1/Smads信号传导通路是调控卵泡发育的重要途径。本文就TGF-β1/Smads信号传导通路与哺乳动物卵巢卵泡的发育进行综述,分别从TGF-β受体、Smads蛋白、骨形态发生蛋白(BMP)、血小板反应蛋白1(THB-S1)、S期激酶相关蛋白1(SKP1)和其他调节机制阐述TGF-β1/Smads信号传导通路在哺乳动物卵巢发育中的调控作用及其机制,旨在引起人们对TGF-β1/Smads调控卵巢发育的关注,并为卵巢发育过程中某些疾病的治疗提供一些参考。

本文引用格式

周敏, 冯强, 黄丽波, 杨在宾, 杨维仁, 姜淑贞 . 转化生长因子β1/Smads信号传导通路在哺乳动物卵巢发育中的调控作用及其作用机制[J]. 动物营养学报, 2017 , 29(7) : 2283 -2288 . DOI: 10.3969/j.issn.1006-267x.2017.07.010

Abstract

The normally operation of the program within the body is depend on the coordination among different signal transduction pathways. transforming growth factor (TGF)-β1/Smads signaling pathway among numerous pathways has received increasing attention by scholars and became a research hot point in molecular and cell biology. It has been confirmed that TGF-β1/Smads signaling pathway is the indispensible way to regulate the development of ovarian follcles. In this paper, the regulatory role and mechanism of TGF-β1/Smads signaling pathway in mammalian ovarian development were reviewed in aspect of TGF-β receptor, Smads protein, bone morphogenetic protein (BMP), thrombospondin 1 (THB-S1), S-phase kinase association protein 1 (SKP1) and other regulatory mechanism. This review is aim to draw attention to the regulation of TGF-β1/Smads in ovarian development and provide some reference for the treatment of some diseases during ovarian development.

参考文献

[1] 金华,丁家怡,朱庆文.颗粒细胞在未成熟卵体外培养时对未成熟卵母细胞发育的影响[J].齐齐哈尔医学院学报,2006,27(3):309-310.

[2] SHULL M M,DOETSCHMAN T.Transforming growth factor-β1 in reproduction[J].Molecular Reproduction and Development,1994,39(2):239-246.  

[3] 郭永红,罗金燕.TGF-β超家族与Smad信号转导研究进展[J].医学综述,2005,11(8):685-688.

[4] DIJKE P T,GOUMANS M J,ITOH F,et al.Regulation of cell proliferation by Smad proteins[J].Journal of Cellular Physiology,2002,191(1):1-16.  

[5] GRÖNROOS E,KINGSTON IJ,RAMACHANDRAN A,et al. Transforming Growth Factor β inhibits Bone Morphogenetic Protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes[J].Molecular and Cellular Biology,2012,32(14):2904-2916.  

[6] 徐梦思.TGFβ-SMAD信号通路对猪颗粒细胞和繁殖性状的作用研究[D].硕士学位论文.石河子:石河子大学,2015:1-20.

[7] 赵瑛,罗玉玉,张文成.TGF-β1/Smads信号通路与eNOS在内皮细胞稳态及动脉粥样硬化发生中的作用[J].武警后勤学院学报:医学版,2013,22(6):560-563.

[8] 张勇,秦娜,于斌.TGF-β/Smads信号转导通路的研究进展[J].广西医科大学学报,2009,26(1):155-157.

[9] 高娜,吴涛.TGF-β在卵巢癌中作用的研究进展[J].大连医科大学学报,2012,34(4):409-413.

[10] LIU S J,DE BOECK M,VAN DAM H,et al.Regulation of the TGF-β pathway by deubiquitinases in cancer[J].The International Journal of Biochemistry & Cell Biology,2016,76:135-145.

[11] BORSUTZKY S,CAZAC B B,ROES J,et al.TGF-β receptor signaling is critical for mucosal IgA responses[J].Journal of Immunology,2004,173(5):3305-3309.  

[12] DE CAESTECKER M.The transforming growth factor-β superfamily of receptors[J].Cytokine and Growth Factor Reviews,2004,15(1):1-11.  

[13] WANG X F,LIN H Y,NG-EATON E,et al.Expression cloning and characterization of the TGF-β type Ⅲ receptor[J].Cell,1991,67(4):797-805.  

[14] 程敏,闻良珍.转化生长因子β及其受体与卵泡发育[J].国外医学:妇产科学分册,2001,28(5):261-264.

[15] PANGAS S A,MATZUK M M.Genetic models for transforming growth factor β superfamily signaling in ovarian follicle development[J].Molecular and Cellular Endocrinology,2004,225(1/2):83-91.

[16] 明佳.Smads蛋白家族与TGF-β的细胞内信号转导[J].国外医学:分子生物学分册,2003,25(2):89-93.

[17] 陈峰,郑敏,陈智.Smad2和Smad3在TGF-β1信号转导中的作用[J].国际流行病学传染病学杂志,2006,33(3):187-189.

[18] 陈骏,钱云良.TGF-β/Smads通路与增生性瘢痕肌成纤维细胞分化[J].中国美容医学杂志,2007,16(7):1000-1003.

[19] TOMIC D,MILLER K P,KENNY H A,et al.Ovarian follicle development requires Smad3[J].Molecular Endocrinology,2004,18(9):2224-2240.  

[20] SASSEVILLE M,RITTER L J,NGUYEN T M,et al.Growth differentiation factor 9 signaling requires ERK1/2 activity in mouse granulosa and cumulus cells[J].Journal of Cell Science,2010,123(18):3166-3176.  

[21] PANGAS S A,LI X H,ROBERTSON E J,et al.Premature luteinization and cumulus cell defects in ovarian-specific Smad4 knockout mice[J].Molecular Endocrinology,2006,20(6):1406-1422.  

[22] 安新玲,韩金祥,王世立.骨形态发生蛋白的研究进展[J].食品与药品,2009,11(6):69-73.

[23] 王伟.BMP/Smad信号通路对猪卵泡颗粒细胞的影响[D].博士学位论文.南京.南京农业大学,2010:1-13.

[24] 王伟,王少兵,徐银学.BMP/Smad信号通路与哺乳动物卵泡发生[J].遗传,2009,31(3):245-254.

[25] ERICKSON G F,SHIMASAKI S.The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle[J].Reproductive Biology and Endocrinology,2003,1(1):9.

[26] FENG N P,WANG Z F,ZHANG Z,et al.miR-487b promotes human umbilical vein endothelial cell proliferation,migration,invasion and tube formation through regulating THBS1[J].Neuroscience Letters,2015,591:1-7.

[27] ADAMS J C,LAWLER J.The thrombospondins[J].The International Journal of Biochemistry and Cell Biology,2004,36(6):961-968.  

[28] NAGANUMA H,SATOH E,KAWATAKI T,et al.Cell density regulates thrombospondin-1 production in malignant glioma cells[J].Journal of Neuro-Oncology,2003,63(2):147-153.  

[29] HUGO C,DANIEL C.Thrombospondin in renal disease[J].Nephron Experimental Nephrology,2009,111(3):e61-e66.

[30] LAWLER J.Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth[J].Journal of Cellular and Molecular Medicine,2002,6(1):1-12.  

[31] ZHOU Z Q,CAO W H,XIE J J,et al.Expression and prognostic significance of THBS1,Cyr61 and CTGF in esophageal squamous cell carcinoma[J].BMC Cancer,2009,9(1):291.

[32] MURPHY-ULLRICH J E,POCZATEK M.Activation of latent TGF-β by thrombospondin-1:mechanisms and physiology[J].Cytokine and Growth Factor Reviews,2000,11(1/2):59-69.

[33] LAWLER J,SUNDAY M,THIBERT V,et al.Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia[J].Journal of Clinical Investigation,1998,101(5):982-992.  

[34] BAI C,SEN P,HOFMANN K,et al.SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif,the F-box[J].Cell,1996,86(2):263-274.  

[35] FELDMAN R M R,CORRELL C C,KAPLAN K B,et al.A complex of Cdc4p,Skp1p,and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p[J].Cell,1997,91(2):221-230.  

[36] CONNELLY C,HIETER P.Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression[J].Cell,1996,86(2):275-285.  

[37] 王宇峰.Skp1蛋白在小鼠早期胚胎发育过程中的功能研究[D].硕士学位论文.南京:南京医科大学,2008.
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