综述 Review

成纤维细胞生长因子23在骨矿物质代谢中的作用及其调控机理

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  • 1. 沈阳农业大学畜牧兽医学院, 沈阳 110866;
    2. 沈阳204医院, 沈阳 110043
董中亮(1983-),男,河南郑州人,硕士研究生,从事动物生理学与生殖内分泌学研究。E-mail:57694996@qq.com.cn

收稿日期: 2017-03-12

  网络出版日期: 2017-09-28

基金资助

国家自然科学基金(31672510)

Fibroblast Growth Factor-23:Functions in Bone Mineral Metabolism and Regulation Mechanism

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  • 1. College of Veterinary and Animal Science, Shenyang Agricultural University, Shenyang 110866, China;
    2. Shenyang 204 Hospital, Shenyang 110043, China

Received date: 2017-03-12

  Online published: 2017-09-28

摘要

骨源性激素成纤维细胞生长因子23(FGF23)介导由甲状旁腺、肾脏、骨骼和维生素D组成的负反馈回路,建立"骨骼-肾脏-甲状旁腺"内分泌轴,参与骨矿物质代谢并发挥重要作用。钙、磷、铁、维生素D、甲状旁腺素(PTH)、成纤维细胞生长因子受体(FGFR)/FGF以及蛋白质翻译后修饰调控FGF23的分泌、活性和胞内过程。随着深入的研究,探索出了一些以FGF23为靶点治疗骨矿物质代谢障碍疾病的新疗法。本文综述了FGF23在骨矿物质代谢中的作用及其调控机理的研究进展,以期为相关研究提供参考依据。

本文引用格式

董中亮, 任晓曼, 卜舒扬, 闪爱婷, 王玉婷, 杨建成 . 成纤维细胞生长因子23在骨矿物质代谢中的作用及其调控机理[J]. 动物营养学报, 2017 , 29(10) : 3467 -3471 . DOI: 10.3969/j.issn.1006-267x.2017.10.006

Abstract

fibroblast growth factor-23 (FGF23) as a bone-derived hormone plays an important role in bone mineral metabolism by mediating the negative feedback loops formed by parathyroid gland, kidney, bone and vitamin D to constructing a bone-kidney-parathyroid gland endocrine axis. The secretion, activity and intracellular processes of FGF23 are regulated by calcium, phosphate, iron, vitamin D, parathyroid hormone (PTH), fibroblast growth factor receptor (FGFR)/FGF and posttranslational modifications. With the increase of study on FGF23, the researchers have explored new therapeutic interventions on bone mineral metabolism disorder. In order to provide reference for relevant research, functions and regulation mechanism of FGF23 in bone mineral metabolism were reviewed in this paper.

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