综述 Review

水产动物肠道健康与饲料添加剂

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  • 1. 长江大学动物科学学院水产系, 荆州 434025;
    2. 中国水产科学研究院长江水产研究所, 农业部淡水生物多样性保护重点实验室, 武汉 430223
田娟(1983-),女,湖北蕲春人,助理研究员,博士,主要从事鱼类营养学研究。E-mail:tianjuan@yfi.ac.cn

收稿日期: 2017-07-11

  网络出版日期: 2018-01-04

基金资助

现代农业产业技术体系建设专项资金项目(CARS-46);长江大学湿地生态与农业利用教育部工程研究中心开放课题(kf201611);湖北省教育厅项目(B2016035)

Research Advances: Intestinal Health and Feed Additives in Aquatic Animals

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  • 1. Department of Aquaculture, College of Animal Science, Yangtze University, Jingzhou 434025, China;
    2. Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China

Received date: 2017-07-11

  Online published: 2018-01-04

摘要

肠道健康水平决定着动物的健康状况,肠道健康是保障动物快速生长的关键因素之一,一些外源性饲料添加剂可以改善动物的肠道健康。本文总结了国内外在畜禽和水产动物上已报道的可改善动物肠道健康的添加剂,包括功能性氨基酸、锌、脂肪酸、益生菌、多糖等,综述了其对动物肠道结构和功能的影响,并阐述了部分作用机制,以期为改善水产动物肠道健康提供参考。

本文引用格式

田娟, 郜卫华, 文华 . 水产动物肠道健康与饲料添加剂[J]. 动物营养学报, 2018 , 30(1) : 7 -13 . DOI: 10.3969/j.issn.1006-267x.2018.01.002

Abstract

Intestinal health is vital for body health, therefore, it is one of the key factors in ensuring rapid growth of animals, and some exogenous feed additive can improve intestinal health in animals. This article reviewed the recent research progress of feed additives which could improve intestinal health of animals at home and abroad, including functional amino acids, zinc, fatty acids, probiotics, polysaccharide, etc, and reviewed the influence of them on animal intestinal structure and function, to provide theoretical basis and reference for aquatic animals health.

参考文献

[1] 周小秋.营养物质与鱼肠道健康的关系[C]//动物营养研究进展(2012年版).北京:中国畜牧兽医学会动物营养学分会,2012:246-260.

[2] 余冰,张克英,郑萍,等.猪营养与肠道健康[J].中国畜牧杂志,2010,46(15):73-76.

[3] 谷珉.影响海水鱼虾对植物蛋白利用的抗营养因子和蛋氨酸的研究[D].博士学位论文.青岛:中国海洋大学,2013:14.

[4] WU G Y.Functional amino acids in growth,reproduction,and health[J].Advances in Nutrition:An International Review Journal,2010,1(1):31-37.  

[5] CURI R,LAGRANHA C J,DOI S Q,et al.Molecular mechanisms of glutamine action[J].Journal of Cellular Physiology,2005,204(2):392-401.  

[6] XI P B,JIANG Z Y,ZHENG C T,et al.Regulation of protein metabolism by glutamine:implications for nutrition and health[J].Frontiers in Bioscience,2011,16(2):578-597.

[7] MARC R J,WU G Y.Glutamine,arginine,and leucine signaling in the intestine[J].Amino Acids,2009,37(1):111-122.  

[8] DAI Z L,LI X L,XI P B,et al.L-glutamine regulates amino acid utilization by intestinal bacteria[J].Amino Acids,2013,45(3):501-512.  

[9] YI G F,CARROLL J A,ALLEE G L,et al.Effect of glutamine and spray-dried plasma on growth performance,small intestinal morphology,and immune responses of Escherichia coli K88+-challenged weaned pigs[J].Journal of Animal Science,2005,83(3):634-643.  

[10] CHEN G,SHI J,QI M,et al.Glutamine decreases intestinal nuclear factor kappa B activity and pro-inflammatory cytokine expression after traumatic brain injury in rats[J].Inflammation Research,2008,57(2):57-64.  

[11] ZHOU Y X,ZHANG P S,DENG G C,et al.Improvements of immune status,intestinal integrity and gain performance in the early-weaned calves parenterally supplemented with L-alanyl-L-glutamine dipeptide[J].Veterinary Immunology and Immunopathology,2012,145(1/2):134-142.

[12] UENO P M,ORIÁ R B,MAIER E A,et al.Alanyl-glutamine promotes intestinal epithelial cell homeostasis in vitro and in a murine model of weanling undernutrition[J].American Journal of Physiology Gastrointestinal and Liver Physiology,2011,301(4):G612-G622.

[13] HAYNES T E,LI P,LI X L,et al.L-glutamine or L-alanyl-L-glutamine prevents oxidant-or endotoxin-induced death of neonatal enterocytes[J].Amino Acids,2009,37(1):131-142.  

[14] BRAGA-NETO M B,OLIVEIRA B M C,RODRIGUES R S,et al.Protective effects of alanyl-glutamine supplementation against nelfinavir-induced epithelial impairment in IEC-6 cells and in mouse intestinal mucosa[J].Cancer Biology & Therapy,2012,13(14):1482-1490.  

[15] AVISSAR N E,ZIEGLER T R,TOIA L,et al.ATB0/ASCT2 expression in residual rabbit bowel is decreased after massive enterectomy and is restored by growth hormone treatment[J].The Journal of Nutrition,2004,134(9):2173-2177.

[16] POHLENZ C,BUENTELLO A,BAKKE A M,et al.Free dietary glutamine improves intestinal morphology and increases enterocyte migration rates,but has limited effects on plasma amino acid profile and growth performance of channel catfish Ictalurus punctatus[J].Aquaculture,2012,370/371:32-39.

[17] YAN L,ZHOU X Q.Dietary glutamine supplementation improves structure and function of intestine of juvenile Jian carp (Cyprinus carpio var.Jian)[J].Aquaculture,2006,256(1/2/3/4):389-394.

[18] CHEN J,ZHOU X Q,FENG L,et al.Effects of glutamine on hydrogen peroxide-induced oxidative damage in intestinal epithelial cells of Jian carp (Cyprinus carpio var.Jian)[J].Aquaculture,2009,288(3/4):285-289.

[19] 徐贺,郑伟,陈秀梅,等.丙氨酰-谷氨酰胺和γ-氨基丁酸对建鲤生长、饲料利用及体成分的影响[J].华南农业大学学报,2016,37(2):7-13.

[20] 徐奇友,王常安,许红,等.丙氨酰-谷氨酰胺对哲罗鱼仔鱼生长和抗氧化能力的影响[J].动物营养学报,2009,21(6):1012-1017.

[21] WU G Y,BAZER F W,DAVIS T A,et al.Important roles for the arginine family of amino acids in swine nutrition and production[J].Livestock Science,2008,112(1/2):8-22.

[22] SUKHOTNIK I,HELOU H,MOGILNER J,et al.Oral arginine improves intestinal recovery following ischemia-reperfusion injury in rat[J].Pediatric Surgery International,2005,21(3):191-196.  

[23] ZHAN Z F,OU D Y,PIAO X S,et al.Dietary arginine supplementation affects microvascular development in the small intestine of early-weaned pigs[J].The Journal of Nutrition,2008,138(7):1304-1307.

[24] WU X,RUAN Z,GAO Y L,et al.Dietary supplementation with L-arginine or N-carbamylglutamate enhances intestinal growth and heat shock protein-70 expression in weanling pigs fed a corn-and soybean meal-based diet[J].Amino Acids,2010,39(3):831-839.  

[25] RHOADS J M,CHEN W,GOOKIN J,et al.Arginine stimulates intestinal cell migration through a focal adhesion kinase dependent mechanism[J].Gut,2004,53(4):514-522.  

[26] CHENG Z Y,BUENTELLO A,GATLIN D M.Effects of dietary arginine and glutamine on growth performance,immune responses and intestinal structure of red drum,Sciaenops ocellatus[J].Aquaculture,2011,319(1/2):247-252.

[27] JIANG J,SHI D,ZHOU X Q,et al.In vitro and in vivo protective effect of arginine against lipopolysaccharide induced inflammatory response in the intestine of juvenile Jian carp (Cyprinus carpio var.Jian)[J].Fish & Shellfish Immunology,2015,42(2):457-464.  

[28] HOERR R A,MATTHEWS D E,BIER D M,et al.Effects of protein restriction and acute refeeding on leucine and lysine kinetics in young men[J].American Journal of Physiology,1993,264(4 Pt 1):E567-E575.

[29] BERTOLO R F,CHEN C Z,LAW G,et al.Threonine requirement of neonatal piglets receiving total parenteral nutrition is considerably lower than that of piglets receiving an identical diet intragastrically[J].The Journal of Nutrition,1998,128(10):1752-1759.

[30] FAURE M,MOËNNOZ D F,MONTIGON F,et al.Dietary threonine restriction specifically reduces intestinal Mucin synthesis in rats[J].The Journal of Nutrition,2005,135(3):486-491.

[31] WANG W W,ZENG X F,MAO X B,et al.Optimal dietary true ileal digestible threonine for supporting the mucosal barrier in small intestine of weanling pigs[J].Journal of Nutrition,2010,140(5):981-986.  

[32] WANG X,QIAO S Y,YIN Y L,et al.A deficiency or excess of dietary threonine reduces protein synthesis in jejunum and skeletal muscle of young pigs[J].Journal of Nutrition,2007,137(6):1442-1446.

[33] RIEDIJK M A,VAN GOUDOEVER J B.Splanchnic metabolism of ingested amino acids in neonates[J].Current Opinion in Clinical Nutrition and Metabolic Care,2007,10(1):58-62.  

[34] STOLL B,HENRY J,REEDS P J,et al.Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk protein-fed piglets[J].Journal of Nutrition,1998,128(3):606-614.

[35] WEN H L,FENG L,JIANG W D,et al.Dietary tryptophan modulates intestinal immune response,barrier function,antioxidant status and gene expression of TOR and Nrf2 in young grass carp (Ctenopharyngodon idella)[J].Fish & Shellfish Immunology,2014,40(1):275-287.  

[36] 冯琳,彭艳,刘扬,等.晶体苏氨酸和微囊苏氨酸对幼建鲤生长性能和消化吸收能力影响的比较研究[J].动物营养学报,2011,23(5):771-780.

[37] LI X L,YIN J D,LI D F,et al.Dietary supplementation with zinc oxide increases IGF-Ⅰ and IGF-Ⅰ receptor gene expression in the small intestine of weanling piglets[J].The Journal of Nutrition,2006,136(7):1786-1791.

[38] OU D Y,LI D F,CAO Y H,et al.Dietary supplementation with zinc oxide decreases expression of the stem cell factor in the small intestine of weanling pigs[J].Journal of Nutritional Biochemistry,2007,18(12):820-826.  

[39] WANG X Q,OU D Y,YIN J D,et al.Proteomic analysis reveals altered expression of proteins related to glutathione metabolism and apoptosis in the small intestine of zinc oxide-supplemented piglets[J].Amino Acids,2009,37(1):209-218.  

[40] 谭丽娜.锌对幼建鲤消化吸收能力、免疫能力和抗氧化功能的影响[D].硕士学位论文.成都:四川农业大学,2009.

[41] JACOBSON K,MUNDRA H,INNIS S M.Intestinal responsiveness to experimental colitis in young rats is altered by maternal diet[J].American Journal of Physiology Gastrointestinal & Liver Physiology,2005,289(1):G13-G20.

[42] CAPLAN M S,JILLING T.The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis[J].Lipids,2001,36(9):1053-1057.  

[43] USAMI M,MURAKI K,IWAMOTO M,et al.Effect of eicosapentaenoic acid (EPA) on tight junction permeability in intestinal monolayer cells[J].Clinical Nutrition,2001,20(4):351-359.  

[44] DE QUELEN F,CHEVALIER J,ROLLI-DERKINDEREN M,et al.n-3 polyunsaturated fatty acids in the maternal diet modify the postnatal development of nervous regulation of intestinal permeability in piglets[J].Journal of Physiology,2011,589(17):4341-4352.  

[45] HANSEN G H,RASMUSSEN K,NIELS-CHRISTIANSEN L L,et al.Dietary free fatty acids form alkaline phosphatase-enriched microdomains in the intestinal brush border membrane[J].Molecular Membrane Biology,2011,28(2):136-144.  

[46] ZENTEK J,BUCHHEIT-RENKO S,MÄNNER K,et al.Intestinal concentrations of free and encapsulated dietary medium-chain fatty acids and effects on gastric microbial ecology and bacterial metabolic products in the digestive tract of piglets[J].Archives of Animal Nutrition,2012,66(1):14-26.  

[47] 王猛强,黄晓玲,金敏,等.饲料中添加植物精油对凡纳滨对虾生长性能及肠道健康的改善作用[J].动物营养学报,2015,27(4):1163-1171.

[48] 梁勇,秦环龙.益生菌调节肠内细胞信号通路研究进展[J].中华临床营养杂志,2012,20(2):112-116.

[49] 夏磊,赵明军,张洪玉,等.不同比例复合益生菌对凡纳滨对虾生长、免疫及抗氨氮能力的影响[J].中国水产科学,2015,22(6):1299-1307.

[50] 胡毅,谭北平,麦康森,等.饲料中益生菌对凡纳滨对虾生长、肠道菌群及部分免疫指标的影响[J].中国水产科学,2008,15(2):244-251.

[51] 马西艺,乐国伟,施用晖,等.乳杆菌肽聚糖对结肠癌细胞的抑制作用及其免疫机制研究[J].营养学报,2004,26(6):467-470.

[52] 王秀武,杜昱光,白雪芳,等.壳寡糖对肉仔鸡肠道主要菌群、小肠微绒毛密度、免疫功能及生产性能的影响[J].动物营养学报,2003,15(4):32-35.

[53] 盛清凯,姚惠源.低聚糖对肠道菌群的调节机理[J].动物科学与动物医学,2002,19(2):35-38.

[54] 韩立丽,王建发,王凤龙,等.黄芪多糖对肠道免疫功能影响的研究进展[J].中国畜牧兽医,2009,36(8):133-135.

[55] 黄玉章,林旋,王全溪,等.黄芪多糖对罗非鱼肠绒毛形态结构及肠道免疫细胞的影响[J].动物营养学报,2010,22(1):108-116.
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