综述 Review

脂多糖引起炎症反应的表观遗传学机制及其营养调控

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  • 西南大学动物科技学院, 重庆市牧草与草食家畜重点实验室, 重庆 400716
陈静波(1993-),男,四川乐山人,硕士研究生,从事动物营养与免疫研究。E-mail:1195246816@qq.com

收稿日期: 2017-06-14

  网络出版日期: 2018-01-04

基金资助

国家自然科学基金面上项目(31672448);重庆市科委社会民生科技创新专项(cstc2016shmszx80078)

Epigenetic Mechanisms of Lipopolysaccharide-Induced Inflammation and Their Nutritional Manipulations

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  • Chongqing Key Laboratory of Forage and Herbivores, College of Animal Science and Technology, Southwest University, Chongqing 400716, China

Received date: 2017-06-14

  Online published: 2018-01-04

摘要

在动物实际生产中,空气、饮水、饲料和粪便中广泛存在脂多糖,此外热应激和饲喂高精料饲粮等也使消化道产生较多脂多糖。脂多糖进入体内后可引起机体发生炎症反应。研究脂多糖引起炎症反应的分子机制及其调控途径,对于提高动物健康水平和生产性能具有重要的意义。从表观遗传学角度,可以在分子层面更加深入透彻地认识炎症反应的发生机制。另外,营养因素和表观遗传变化之间存在密切的关系。本文就脂多糖引起炎症反应的表观遗传学机制及其营养调控做一综述。

本文引用格式

陈静波, 董国忠, 孙雅望, 张翥 . 脂多糖引起炎症反应的表观遗传学机制及其营养调控[J]. 动物营养学报, 2018 , 30(1) : 59 -65 . DOI: 10.3969/j.issn.1006-267x.2018.01.009

Abstract

In practical animal production, lipopolysaccharide widely exists in air, drinking water, feed and feces. In addition, heat stress and the feeding of high concentrate diets also lead to release of more lipopolysaccharide in digestive tract. When lipopolysaccharide enters the body, it can cause inflammation. Studying molecular mechanisms and manipulative avenues of lipopolysaccharide-induced inflammation is of great significance for improving animal health and production performance. From an epigenetic point of view, mechanisms of inflammation may be better understood at the molecular level. Moreover, there is a close relationship between nutritional factors and epigenetic alterations. This article reviewed the epigenetic mechanisms of lipopolysaccharide-induced inflammation and their nutritional manipulations.

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