综述 Review

锌对哺乳动物卵母细胞质量的影响及其作用途径

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  • 1. 四川农业大学动物营养研究所, 成都 611130;
    2. 四川华德生物工程有限公司, 成都 610063
徐盛玉(1983-),女,四川自贡人,副研究员,博士,主要从事动物营养与饲料科学研究。E-mail:shengyuxu@sicau.edu.cn

收稿日期: 2017-08-25

  网络出版日期: 2018-03-05

基金资助

四川农业大学引进人才科研启动项目;四川农业大学"双支计划"项目

Effects and Action Pathway of Zinc on Mammalian Oocyte Quality

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  • 1. Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China;
    2. Sichuan Rota Bioengineering Co., Ltd., Chengdu 610063, China

Received date: 2017-08-25

  Online published: 2018-03-05

摘要

卵母细胞质量直接影响受精率、早期胚胎存活,甚至成年后的疾病。锌是动物必需微量元素之一,是迄今为止发现的动物必需微量元素中功能最多的一种,近年来科学家们发现其在卵母细胞质量调控上发挥了重要作用。研究表明,锌可通过影响成熟促进因子(MPF)活性和丝裂原活化蛋白激酶(MAPK)信号通路影响卵母细胞减数分裂,通过谷胱甘肽影响卵母细胞抗氧化功能,并能通过影响组蛋白和DNA甲基化水平等途径影响动物卵母细胞质量。本文就锌对哺乳动物卵母细胞质量的影响及其作用途径作一综述。

本文引用格式

徐盛玉, 吴小玲, 王定越 . 锌对哺乳动物卵母细胞质量的影响及其作用途径[J]. 动物营养学报, 2018 , 30(3) : 807 -812 . DOI: 10.3969/j.issn.1006-267x.2018.03.001

Abstract

The quality of the oocytes directly affects its fertilization rate, the survival of early embryos, and even the adult disease. Zinc, one of the essential trace elements in mammalian, is the most functional one in the trace elements till now. Recent researchers have found that zinc play important roles in the oocyte quality. It have indicated that zinc has the regulatory function in oocyte meiosis through maturation promoting factor (MPF) activity and mitogen-activated protein kinase (MAPK) signaling pathway. Zinc regulate oocyte antioxidant function through glutathione, and affect animal oocyte quality by influence the level of histone and DNA methylation. This paper will review the effects of zinc on the mammalian oocyte quality and its action pathway.

Key words: zinc; mammalian; oocyte; quality

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