综述 Review

肠道微生物对家禽肠道免疫功能的调节作用及其机制

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  • 上海市农业科学院畜牧兽医研究所, 国家家禽工程技术研究中心, 上海 201106
朱丽慧(1985-),女,江苏南通人,助理研究员,博士,主要从事家禽营养调控机制研究。E-mail:zlh309@163.com

收稿日期: 2017-07-11

  网络出版日期: 2018-03-05

基金资助

上海市农业科学院卓越团队建设计划;国家蛋鸡产业技术体系(CARS-40-K03);国家自然科学基金(31502056)

Immunity System Regulated by Gut Microbiota of Poultry and Its Mechanisms

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  • National Research Center of Poultry Engineering and Technology, Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China

Received date: 2017-07-11

  Online published: 2018-03-05

摘要

家禽肠道中定植了大量微生物,这些微生物及其代谢产物积极参与家禽的消化与免疫应答过程,对家禽健康发挥重要的调控作用。随着抗生素在全球范围内的限制或禁用,家禽肠道问题日益突出,给养殖者带来巨大经济损失。然而,对家禽肠道微生物菌群的研究还停留在相对初级的阶段。本文首先综述了家禽肠道微生物的组成以及家禽肠道健康营养调控措施的研究现状,并进一步深入探讨了肠道微生物基因组及其代谢产物对动物肠道免疫功能的调节作用,以及肠黏膜免疫系统对肠道微生物调控的潜在机制,旨在为进一步研究改善家禽肠道健康的营养措施提供参考。

本文引用格式

朱丽慧, 廖荣荣, 杨长锁 . 肠道微生物对家禽肠道免疫功能的调节作用及其机制[J]. 动物营养学报, 2018 , 30(3) : 820 -828 . DOI: 10.3969/j.issn.1006-267x.2018.03.003

Abstract

A vast diversity of microbes colonizes in the poultry gastrointestinal tract, referred to intestinal microbiota. Microbiota and products thereof are indispensable for shaping the functions of poultry digestive and immune system, thereby exerting multifaceted impacts in gut health. As antibiotics are restricted or disabled worldwide, the issue of the intestinal problems of poultry is becoming more and more serious, causing huge economic losses for the farmers. However, the researches on the intestinal microbial flora of poultry are still at a relatively early stage. This paper reviewed the composition of poultry gut microbiota and current nutrition studies on poultry gut health control. Then, we discussed the effects on immunity of gut microbe-derived nucleic acids and gut microbial metabolites, as well as the involvement of commensals in the gut homeostasis. In addition, we further focused on the recent findings with an intention to illuminate the mechanisms about how the gastrointestinal mucosa immunity system regulating gut microbiota, hoping to provide some evidences for further poultry gut health protection.

参考文献

[1] LEY R E,PETERSON D A,GORDON J I.Ecological and evolutionary forces shaping microbial diversity in the human intestine[J].Cell,2006,124(4):837-848.  

[2] ATARASHI K,HONDA K.Microbiota in autoimmunity and tolerance[J].Current Opinion in Immunology,2011,23(6):761-768.  

[3] YEGANI M,KORVER D R.Factors affecting intestinal health in poultry[J].Poultry Science,2008,87(10):2052-2063.  

[4] CHOCT M.Managing gut health through nutrition[J].British Poultry Science,2009,50(1):9-15.  

[5] REHMAN H U,VAHJEN W,AWAD W A,et al.Indigenous bacteria and bacterial metabolic products in the gastrointestinal tract of broiler chickens[J].Archives of Animal Nutrition,2007,61(5):319-335.  

[6] CHOI J H,KIM G B,CHA C J.Spatial heterogeneity and stability of bacterial community in the gastrointestinal tracts of broiler chickens[J].Poultry Science,2014,93(8):1942-1950.  

[7] QUINTEIRO-FILHO W M,RIBERIO A,FERRAZ-DE-PAULA V,et al.Heat stress impairs performance parameters,induces intestinal injury,and decreases macrophage activity in broiler chickens[J].Poultry Science,2010,89(9):1905-1914.  

[8] FRITZ J C,MISLIVEC P B,PLA G W,et al.Toxicogenicity of moldy feed for young chicks[J].Poultry Science,1973,52(4):1523-1530.  

[9] VAN IMMERSEEL F,DE BUCK J,PASMANS F,et al.Clostridium perfringens in poultry:an emerging threat for animal and public health[J].Avian Pathology,2004,33(6):537-549.  

[10] CRHANOVA M,HRADECKA H,FALDYNOVA M,et al.Immune response of chicken gut to natural colonization by gut microflora and to Salmonella enterica serovar enteritidis infection[J].Infection and Immunity,2011,79(7):2755-2763.  

[11] BRANTON S L,LOTT B D,DEATON J W,et al.The effect of added complex carbohydrates or added dietary fiber on necrotic enteritis lesions in broiler chickens[J].Poultry Science,1997,76(1):24-28.  

[12] FERNANDEZ F,SHARMA R,HINTON M,et al.Diet influences the colonisation of Campylobacter jejuni and distribution of mucin carbohydrates in the chick intestinal tract[J].Cellular and Molecular Life Sciences,2000,57(12):1793-17801.  

[13] PHILLIPS N D,LA T,PLUSKE J R,et al.A wheat-based diet enhances colonization with the intestinal spirochaete Brachyspira intermedia in experimentally infected laying hens[J].Avian Pathology,2004,33(4):451-457.  

[14] SIMON K,VERWOOLDE M B,ZHANG J,et al.Long-term effects of early life microbiota disturbance on adaptive immunity in laying hens[J].Poultry Science,2016,95(7):1543-1554.  

[15] KIM G B,Seo Y M,KIM C H,et al.Effect of dietary prebiotic supplementation on the performance,intestinal microflora,and immune response of broilers[J].Poultry Science,2011,90(1):75-82.  

[16] PENDER C M,KIM S,POTTER T D,et al.In ovo supplementation of probiotics and its effects on performance and immune-related gene expression in broiler chicks[J].Poultry Science,2017,96(5):1052-1062.

[17] KAREEM K Y,LOH T C,FOO H L,et al.Effects of dietary postbiotic and inulin on growth performance,IGF1 and GHR mRNA expression,faecal microbiota and volatile fatty acids in broilers[J].BMC Veterinary Research,2016,12:163.

[18] KIARIE E,ROMERO L F,NYACHOTI C M.The role of added feed enzymes in promoting gut health in swine and poultry[J].Nutrition Research Reviews,2013,26(1):71-88.  

[19] ZHANG W H,JIANG Y,ZHU Q F,et al.Sodium butyrate maintains growth performance by regulating the immune response in broiler chickens[J].British Poultry Science,2011,52(3):292-301.  

[20] RINTTILÄ T,APAJALAHTI J.Intestinal microbiota and metabolites-implications for broiler chicken health and performance[J].The Journal of Applied Poultry Research,2013,22(3):647-658.  

[21] O'NEILL L A.The interleukin-1 receptor/toll-like receptor superfamily:10 years of progress[J].Immunological Reviews,2008,226(1):10-18.  

[22] KAWASAKI T,KAWAI T,AKIRA S.Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity[J].Immunological Reviews,2011,243(1):61-73.  

[23] KRIEG A M,VOLLMER J.Toll-like receptors 7,8,and 9:linking innate immunity to autoimmunity[J].Immunological Reviews,2007,220(1):251-269.  

[24] HALL J A,BOULADOUX N,SUN C M,et al.Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses[J].Immunity,2008,29(4):637-649.  

[25] LAMPHIER M S,SIROIS C M,VERMA A,et al.TLR9 and the recognition of self and non-self nucleic acids[J].Annals of the New York Academy of Sciences,2006,1082:31-43.

[26] BOULADOUX N,HALL J A,GRAINGER J R,et al.Regulatory role of suppressive motifs from commensal DNA[J].Mucosal Immunology,2012,5(6):623-634.  

[27] TROY E B,KASPER D L.Beneficial effects of Bacteroides fragilis polysaccharides on the immune system[J].Frontiers in Bioscience,2010,15(1):25-34.  

[28] HORAI R,SEN H N,CASPI R R.Commensal microbiota as a potential trigger of autoimmune uveitis[J].Expert Review of Clinical Immunology,2017,13(4):291-293.  

[29] DEN BESTEN G,VAN EUNRN K,GROEN A K,et al.The role of short-chain fatty acids in the interplay between diet,gut microbiota,and host energy metabolism[J].Journal of Lipid Research,2013,54(9):2325-2340.  

[30] MACFARLANE S,MACFARLANE G T.Regulation of short-chain fatty acid production[J].Proceedings of the Nutrition Society,2003,62(1):67-72.  

[31] CHANG P V,HAO L M,OFFERMANNS S,et al.The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition[J].Proceedings of the National Academy of Sciences of the United States of America,2014,111(6):2247-2252.  

[32] KOH A,DE VADDER F,KOVATCHEVA-DATCHARY P,et al.From dietary fiber to host physiology:short-chain fatty acids as key bacterial metabolites[J].Cell,2016,165(6):1332-1345.  

[33] SEGAIN J P,DE LA BLÉTIÈRE D R,BOURREILLE A,et al.Butyrate inhibits inflammatory responses through NF-κB inhibition:implications for Crohn's disease[J].Gut,2000,47(3):397-403.  

[34] BROWN C T,DAVIS-RICHARDSON A G,GIONGO A,et al.Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes[J].PLoS One,2011,6(10):e25792.

[35] ARTIS D.Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut[J].Nature Reviews Immunology,2008,8(6):411-420.  

[36] LEWIS K,LUTGENDORFF F,PHAN V,et al.Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate[J].Inflammatory Bowel Diseases,2010,16(7):1138-1148.  

[37] RAQIB R,SARKER P,MILY A,et al.Efficacy of sodium butyrate adjunct therapy in shigellosis:a randomized,double-blind,placebo-controlled clinical trial[J].BMC Infectious Diseases,2012,12(1):111.

[38] ARPAIA N,CAMPBELL C,FAN X Y,et al.Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation[J].Nature,2013,504(7480):451-455.  

[39] BROWN A J,GOLDSWORTHY S M,BARNES A A,et al.The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids[J].The Journal of Biological Chemistry,2003,278(13):11312-11319.  

[40] TOLHUSST G,HEFFRON H,LAM Y S,et al.Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2[J].Diabetes,2012,61(2):364-371.  

[41] KIM M H,KANG S G,PARK J H,et al.Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice[J].Gastroenterology,2013,145(2):396-406.e10.  

[42] DE VADDER F,KOVATCHEVA-DATCHARY P,GONCALVES D,et al.Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits[J].Cell,2014,156(1/2):84-96.

[43] MILLER M B,BASSLER B L.Quorum sensing in bacteria[J].Annual Review of Microbiology,2001,55(1):165-199.  

[44] WATERS C M,BASSLER B L.Quorum sensing:cell-to-cell communication in bacteria[J].Annual Review of Cell and Developmental Biology,2005,21(1):319-346.  

[45] DIGGLE S P,WINZER K,LAZDUNSKI A,et al.Advancing the quorum in Pseudomonas aeruginosa:MvaT and the regulation of N-acylhomoserine lactone production and virulence gene expression[J].Journal of Bacteriology,2002,184(10):2576-2586.  

[46] KIMURA N.Metagenomic approaches to understanding phylogenetic diversity in quorum sensing[J].Virulence,2014,5(3):433-442.  

[47] XAVIER K B,BASSLER B L.LuxS quorum se
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