综述 Review

过瘤胃蛋氨酸对围产期奶牛代谢及健康的调控作用及机理

展开
  • 1. 西北农林科技大学动物科技学院, 杨陵 712100;
    2. 陕西省商洛市畜牧产业发展中心, 商洛 726000
孙博非(1988-),男,山东淄博人,博士,从事反刍动物营养研究和技术服务工作。E-mail:sunfeifei2011@sina.com

收稿日期: 2017-09-04

  网络出版日期: 2018-03-05

基金资助

国家重点研发计划(2017YFD0500500);国家自然科学基金面上项目(31472122,31672451)

Methionine Regulates the Metabolism and Health of Transition Dairy Cows and Its Mechanism

Expand
  • 1. College of Animal Science and Technology, Northwest A & F University, Yangling 712100, China;
    2. The Development Centre of Animal Husbandry in Shangluo City of Shanxi Province, Shangluo 726000, China

Received date: 2017-09-04

  Online published: 2018-03-05

摘要

受多种因素影响,奶牛围产期处于能量和其他营养物质的负平衡状态,多发营养代谢病。研究表明,蛋氨酸可调控奶牛围产期能量和脂质代谢,改善肝脏功能,并可增强机体抗氧化和免疫功能。本文综述了蛋氨酸调控奶牛围产期代谢和机体健康的相关进展,探讨奶牛围产期过瘤胃蛋氨酸的适宜添加量,旨在为蛋氨酸在奶牛围产期的基础研究和应用提供参考。

本文引用格式

孙博非, 余超, 曹阳春, 蔡传江, 李生祥, 姚军虎 . 过瘤胃蛋氨酸对围产期奶牛代谢及健康的调控作用及机理[J]. 动物营养学报, 2018 , 30(3) : 829 -836 . DOI: 10.3969/j.issn.1006-267x.2018.03.004

Abstract

The negative balances of energy and other nutrients usually occur during the transition period because of a series of factors, thereby inducing many metabolic disorders. It is reported that dietary supplementation of rumen-protected methionine can regulate energy and lipid metabolism, improve liver health, and enhance the antioxidant capacity and immune function of transition dairy cows. In this article, the physiological metabolism and body health of transition dairy cows regulated by rumen-protected methionine were reviewed, and the appropriate supplementation doses were discussed as well. Hence, this review could provide references for the fundamental research and application of methionine in transition dairy cows.

参考文献

[1] 余超.生物素对围产期奶牛泌乳净能和代谢蛋白平衡及生产性能的影响[D].硕士学位论文.杨凌:西北农林科技大学,2016.

[2] 孙菲菲,曹阳春,李生祥,等.胆碱对奶牛围产期代谢的调控[J].动物营养学报,2014,26(1):26-33.

[3] 孙菲菲.胆碱和蛋氨酸对奶牛围产期营养平衡和机体健康的影响及机制[D].博士学位论文.杨凌:西北农林科技大学,2017.

[4] LI C,BATISTEL F,OSORIO J S,et al.Peripartal rumen-protected methionine supplementation to higher energy diets elicits positive effects on blood neutrophil gene networks,performance and liver lipid content in dairy cows[J].Journal of Animal Science and Biotechnology,2016,7(1):18.

[5] OSORIO J,TREVISI E,JI P,et al.Biomarkers of inflammation,metabolism,and oxidative stress in blood,liver,and milk reveal a better immunometabolic status in peripartal cows supplemented with Smartamine M or MetaSmart[J].Journal of Dairy Science,2014,97(12):7437-7450.  

[6] OSORIO J,JI P,DRACKLEY J,et al.Smartamine M and MetaSmart supplementation during the peripartal period alter hepatic expression of gene networks in 1-carbon metabolism,inflammation,oxidative stress,and the growth hormone-insulin-like growth factor 1 axis pathways[J].Journal of Dairy Science,2014,97(12):7451-7464.  

[7] JACOMETO C B,ZHOU Z,LUCHINI D,et al.Maternal supplementation with rumen-protected methionine increases prepartal plasma methionine concentration and alters hepatic mRNA abundance of 1-carbon,methionine,and transsulfuration pathways in neonatal Holstein calves[J].Journal of Dairy Science,2017,100(4):3209-3219.  

[8] NAN X M,BU D P,LI X Y,et al.Ratio of lysine to methionine alters expression of genes involved in milk protein transcription and translation and mTOR phosphorylation in bovine mammary cells[J].Physiological Genomics,2014,46(7):268-275.  

[9] 胡诚军,江青艳,孔祥峰.畜禽蛋氨酸代谢及其生理功能研究进展[J].饲料工业,2016,37(15):23-27.

[10] ARDALAN M,DEHGHAN-BANADAKY M,REZAYAZDI K,et al.The effect of rumen-protected methionine and choline on plasma metabolites of Holstein dairy cows[J].The Journal of Agricultural Science,2011,149(5):639-646.  

[11] SUN F F,CAO Y C,CAI C J,et al.Regulation of nutritional metabolism in transition dairy cows:energy homeostasis and health in response to post-ruminal choline and methionine[J].PLoS One,2016,11(8):e0160659.

[12] ZHOU Z,BULGARI O,VAILATI-RIBONI M,et al.Rumen-protected methionine compared with rumen-protected choline improves immunometabolic status in dairy cows during the peripartal period[J].Journal of Dairy Science,2016,99(11):8956-8969.  

[13] SAHOO A,SOREN N.Nutrition for wool production[J].Webmedcentral Nutrition,2011,2(10):WMC002384.

[14] ZHOU Z,VAILATI-RIBONI M,TREVISI E,et al.Better postpartal performance in dairy cows supplemented with rumen-protected methionine compared with choline during the peripartal period[J].Journal of Dairy Science,2016,99(11):8716-8732.  

[15] SINCLAIR K D,GARNSWORTHY P C,MANN G E,et al.Reducing dietary protein in dairy cow diets:implications for nitrogen utilization,milk production,welfare and fertility[J].Animal,2014,8(2):262-274.  

[16] WANG C,LIU H Y,WANG Y M,et al.Effects of dietary supplementation of methionine and lysine on milk production and nitrogen utilization in dairy cows[J].Journal of Dairy Science,2010,93(8):3661-3670.  

[17] HUANG X,ZANG Y L,ZHANG M H,et al.Nuclear factor of κB1 is a key regulator for the transcriptional activation of milk synthesis in bovine mammary epithelial cells[J].DNA and Cell Biology,2017,36(4):295-302.  

[18] OSORIO J S,JACOMETO C B,ZHOU Z,et al.Hepatic global DNA and peroxisome proliferator-activated receptor alpha promoter methylation are altered in peripartal dairy cows fed rumen-protected methionine[J].Journal of Dairy Science,2016,99(1):234-244.  

[19] ZHOU Z,GARROW T A,DONG X W,et al.Hepatic activity and transcription of betaine-homocysteine methyltransferase,methionine synthase,and cystathionine synthase in periparturient dairy cows are altered to different extents by supply of methionine and choline[J].The Journal of Nutrition,2017,147(1):11-19.  

[20] CHANDLER T L,WHITE H M.Choline and methionine differentially alter methyl carbon metabolism in bovine neonatal hepatocytes[J].PLoS One,2017,12(2):e0171080.

[21] SODER K J,HOLDEN L A.Lymphocyte proliferation response of lactating dairy cows fed varying concentrations of rumen-protected methionine[J].Journal of Dairy Science,1999,82(9):1935-1942.  

[22] OSORIO J,JI P,DRACKLEY J K,et al.Supplemental Smartamine M or MetaSmart during the transition period benefits postpartal cow performance and blood neutrophil function[J].Journal of Dairy Science,2013,96(10):6248-6263.  

[23] DENG Q,MA D,SHI Z,et al.Effects of β-hydroxybutyricacid on the synthesis and assembly of very low-density lipoprotein in bovine hepatocytes in vitro[J].Journal of Animal Physiology and Animal Nutrition,2016,100(2):331-336.  

[24] LI Y,DING H Y,WANG X C,et al.High levels of acetoacetate and glucose increase expression of cytokines in bovine hepatocytes,through activation of the NF-κB signalling pathway[J].Journal of Dairy Research,2016,83(1):51-57.  

[25] SHI X,LI X,LI D,et al.β-hydroxybutyrate activates the NF-κB signaling pathway to promote the expression of pro-inflammatory factors in calf hepatocytes[J].Cellular Physiology and Biochemistry,2014,33(4):920-932.  

[26] SHI X X,LI D D,DENG Q H,et al.NEFAs activate the oxidative stress-mediated NF-κB signaling pathway to induce inflammatory response in calf hepatocytes[J].The Journal of Steroid Biochemistry and Molecular Biology,2015,145:103-112.

[27] LACETERA N,FRANCI O,SCALIA D,et al.Effects of nonesterified fatty acids and β-hydroxybutyrate on functions of mononuclear cells obtained from ewes[J].American Journal of Veterinary Research,2002,63(3):414-418.  

[28] LACETERA N,SCALIA D,FRANCI O,et al.Short communication:effects of nonesterified fatty acids on lymphocyte function in dairy heifers[J].Journal of Dairy Science,2004,87(4):1012-1014.  

[29] LACETERA N,SCALIA D,BERNABUCCI U,et al.Lymphocyte functions in overconditioned cows around parturition[J].Journal of Dairy Science,2005,88(6):2010-2016.  

[30] VAILATI-RIBONI M,OSORIO J S,TREVISI E,et al.Supplemental Smartamine M in higher-energy diets during the prepartal period improves hepatic biomarkers of health and oxidative status in Holstein cows[J].Journal of Animal Science and Biotechnology,2017,8(1):17.

[31] AWAWDEH M S.Rumen-protected methionine and lysine:effects on milk production and plasma amino acids of dairy cows with reference to metabolisable protein status[J].Journal of Dairy Research,2016,83(2):151-155.  

[32] ROBINSON P H.Impacts of manipulating ration metabolizable lysine and methionine levels on the performance of lactating dairy cows:A systematic review of the literature[J].Livestock Science,2010,127(2/3):115-126.

[33] ZANTON G I,BOWMAN G R,VÁZQUEZ-AÑÍN M,et al.Meta-analysis of lactation performance in dairy cows receiving supplemental dietary methionine sources or postruminal infusion of methionine[J].Journal of Dairy Science,2014,97(11):7085-7101.  

[34] ACOSTA D A V,DENICOL A C,TRIBULO P,et al.Effects of rumen-protected methionine and choline supplementation on the preimplantation embryo in Holstein cows[J].Theriogenology,2016,85(9):1669-1679.  

[35] DALBACH K F,LARSEN M,RAUN B M L,et al.Effects of supplementation with 2-hydroxy-4-(methylthio)-butanoic acid isopropyl ester on splanchnic amino acid metabolism and essential amino acid mobilization in postpartum transition Holstein cows[J].Journal of Dairy Science,2011,94(8):3913-3927.  

[36] ARDALAN M,REZAYAZDI K,DEHGHAN-BANADAKY M.Effect of rumen-protected choline and methionine on physiological and metabolic disorders and reproductive indices of dairy cows[J].Journal of Animal Physiology and Animal Nutrition,2010,94(6):e259-e265.

[37] ORDWAY R S,BOUCHER S E,WHITEHOUSE N L,et al.Effects of providing two forms of supplemental methionine to periparturient Holstein dairy cows on feed intake and lactational performance[J].Journal of Dairy Science,2009,92(10):5154-5166.  

[38] SOCHA M T,PUTNAM D E,GARTHWAITE B D,et al.Improving intestinal amino acid supply of pre-and postpartum dairy cows with rumen-protected methionine and lysine[J].Journal of Dairy Science,2005,88(3):1113-1126.  

[39] PHILLIPS G J,CITRON T L,SAGE J S,et al.Adaptations in body muscle and fat in transition dairy cattle fed differing amounts of protein a
文章导航

/