综述 Review

蛋氨酸对畜禽繁殖性能的影响及机制

展开
  • 中国农业大学动物科技学院, 北京 100193
蔡爽(1994-),女,湖北宜昌人,硕士研究生,从事猪营养与繁殖相关的研究。E-mail:c_caishuang@163.com

收稿日期: 2017-09-02

  网络出版日期: 2018-03-05

Effects and Mechanism of Methionine on Reproductive Performance of Livestock and Poultry

Expand
  • College of Animal Science and Technology, China Agricultural University, Beijing 100193, China

Received date: 2017-09-02

  Online published: 2018-03-05

摘要

蛋氨酸是动物的必需氨基酸,也是功能性氨基酸。除了参与蛋白质的合成,还可调控细胞增殖分化、胎儿生长发育,并可清除体内自由基,增强机体免疫力,对畜禽的生长发育和繁殖有着重要意义。本文对蛋氨酸的理化性质、体内代谢、胎盘的转运和吸收进行了总结,阐述了蛋氨酸对畜禽繁殖性能的影响及其潜在机制,为今后蛋氨酸在畜禽生产中的进一步深入研究与应用提供参考。

本文引用格式

蔡爽, 叶倩红, 曾祥芳 . 蛋氨酸对畜禽繁殖性能的影响及机制[J]. 动物营养学报, 2018 , 30(3) : 881 -887 . DOI: 10.3969/j.issn.1006-267x.2018.03.010

Abstract

Methionine is one of the essential amino acids in the animal, meanwhile it also can be considered as a functional amino acid. In addition to protein synthesis, it plays an important role in the cell proliferation and differentiation, fetal growth and development, and has great significance in removing free radical and enhancing immunity. This review summarizes the physical and chemical properties of methionine, metabolism, transport and absorption in placental, and discusses its effects on the reproductive performance of livestock and potential regulation mechanism, which can provide a reference for future research and application of methionine.

参考文献

[1] 胡诚军,江青艳,孔祥峰.畜禽蛋氨酸代谢及其生理功能研究进展[J].饲料工业,2016,37(15):23-27.

[2] 朱中胜,李吕木.蛋氨酸研究进展[J].饲料博览,2015(7):11-17.

[3] XU J,SINCLAIR K D.One-carbon metabolism and epigenetic regulation of embryo development[J].Reproduction Fertility and Development,2015,27(4):667-676.  

[4] MIRANDA T B,JONES P A.DNA methylation:The nuts and bolts of repression[J].Journal of Cellular Physiology,2007,213(2):384-390.  

[5] WINTER-VANN A M,KAMEN B A,BERGO M O,et al.Targeting Ras signaling through inhibition of carboxyl methylation:an unexpected property of methotrexate[J].Proceedings of the National Academy of Sciences of the United States of America,2003,100(11):6529-6534.  

[6] STEAD L M,AU K P,JACOBS R L,et al.Methylation demand and homocysteine metabolism:effects of dietary provision of creatine and guanidinoacetate[J].American Journal of Physiology:Endocrinology and Metabolism,2001,281(5):E1095-E1100.

[7] 乔德堂.动物的蛋氨酸营养研究进展[J].山东畜牧兽医,2007,28(4):57-58.

[8] FINKELSTEIN J D.Methionine metabolism in mammals[J].The Journal of Nutritional Biochemistry,1990,1(5):228-237.  

[9] MATO J M,MARTÍNEZ-CHANTAR M L,LU S C.Methionine metabolism and liver disease[J].The Annual Review of Nutrition,2008,28(1):273-293

[10] 石常友,王文策,耿梅梅,等.不同蛋白质水平日粮对肥育猪肠道氨基酸转运载体CAT1 mRNA表达量的影响[J].动物营养学报,2008,20(6):692-698.

[11] 陈云平,吕春梅,朱辉.胎盘氨基酸转运体的研究进展[J].中国妇幼保健,2013,28(26):4416-4418.

[12] HOWIE G J,SLOBODA D M,KAMAL T,et al.Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet[J].The Journal of Physiology,2009,587(4):905-915.  

[13] DESFORGES M,MYNETT K J,JONES R L,et al.The SNAT4 isoform of the system A amino acid transporter is functional in human placental microvillous plasma membrane[J].The Journal of Physiology,2009,587(1):61-72.  

[14] 马婧,谭毅,谭冬梅,等.氨基酸转运载体LAT1对小鼠胎盘早期建立的影响[J].中国实验动物学报,2015,23(3):256-260.

[15] 付国强,计成,马秋刚.日粮蛋氨酸和赖氨酸水平对产蛋高峰期京红蛋种鸡生产和繁殖性能的影响[J].中国畜牧兽医文摘,2013,49(9):52.

[16] XIAO X,WANG Y X,LIU W L,et al.Effects of different methionine sources on production and reproduction performance,egg quality and serum biochemical indices of broiler breeders[J].Asian-Australasian Journal of Animal Sciences,2017,30(6):828-833.

[17] 戴国俊,王志跃,吴兆林,等.不同蛋白质来源对公鸡采精量和精液品质的影响[J].中国畜牧杂志,2000,36(4):32-33.

[18] 黄璇,李闯,何平,等.临武鸭产蛋高峰期蛋氨酸需要量的研究[J].动物营养学报,2015,27(4):1110-1116.

[19] 阮栋,林映才,张罕星,等.蛋氨酸水平对开产期麻鸭产蛋性能、蛋品质及卵巢形态的影响[J].中国畜牧杂志,2012,48(7):34-38.

[20] PEÑAGARICANO F,SOUZA A H,CARVALHO P D,et al.Effect of maternal methionine supplementation on the transcriptome of bovine preimplantation embryos[J]PLoS One,2008,8(8):e72302.

[21] IKEDA S,SUGIMOTO M,KUME S.Importance of methionine metabolism in morula-to-blastocyst transition in bovine preimplantation embryos[J].Journal of Reproduction and Development,2012,58(1):91-97.  

[22] SAADI H S,GAGNÉ D,FOURNIER É,et al.Responses of bovine early embryos to S-adenosyl methionine supplementation in culture[J].Epigenomics,2016,8(8):1039-1060.  

[23] 简勇军,刘国庆,赵丽红,等.日粮蛋氨酸与赖氨酸比值对后备母猪生长及繁殖性能的影响[J].中国畜牧杂志,2016,52(9):32-36.

[24] BARTSOCAS C S,THIER S O,CRAWFORD J D.Transport of L-methionine in rat intestine and kidney[J].Pediatric Research,1974,8(6):673-678.  

[25] 李豪.饲粮蛋氨酸来源和水平对哺乳-断奶仔猪生长及肠道发育的影响[D].硕士学位论文.雅安:四川农业大学,2013:67-78.

[26] NAICHE L A,HARRELSON Z,KELLY R G,et al.T-box genes in vertebrate development[J].Annual Review of Genetics,2005,39(1):219-239.  

[27] 苏文龙,李璐,曹慧,等.DNA甲基化/去甲基化与哺乳动物胚胎的体外发育[J].中国畜牧杂志,2015,51(9):68-71.

[28] REIK W.Stability and flexibility of epigenetic gene regulation in mammalian development[J].Nature,2007,447(7143):425-432.  

[29] DEAN W,SANTOS F,STOJKOVIC M,et al.Conservation of methylation reprogramming in mammalian development:aberrant reprogramming in cloned embryos[J].Proceedings of the National Academy of Sciences of the United States of America,2001,98(24):13734-13738.  

[30] SILVA A R R E,ADENOT P,DANIEL N,et al.Dynamics of DNA methylation levels in maternal and paternal rabbit genomes after fertilization[J].Epigenetics,2011,6(8):987-993.  

[31] ZENG X,WANG F,FAN X,et al.Dietary arginine supplementation during early pregnancy enhances embryonic survival in rats[J].Journal of Nutrition,2008,138(8):1421-1425.  

[32] 黄珍茹,蔡美琴.精氨酸在人早期生长发育过程中的作用[J].上海交通大学学报(医学版),2016,36(3):451-454.

[33] LARQUE E,SABATER-MOLINA M,ZAMORA S.Biological significance of dietary polyamines[J]. Nutrition,2007,23(1):87-95.  

[34] ZHAO Y C,CHI Y J,YU Y S,et al.Polyamines are essential in embryo implantation:expression and function of polyamine-related genes in mouse uterus during peri-implantation period[J].Endocrinology,2008,149(5):2325-2332.  

[35] RAMATHAL C Y,BAGCHI I C,TAYLOR R N,et al.Endometrial decidualization:of mice and men[J].Seminars in Reproductive Medicine,2010,28(1):17-26.  

[36] BAZER F W,SONG G,KIM J,et al.Mechanistic mammalian target of rapamycin (MTOR) cell signaling:effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses.[J].Molecular and Cellular Endocrinolog,2012,354(1/2):22-33.

[37] GASPARRINI B,SAYOUD H,NEGLIA G,et al.Glutathione synthesis during in vitro maturation of buffalo (Bubalus bubalis) oocytes:effects of cysteamine on embryo development[J].Theriogenology,2003,60(5):943-952.  

[38] DRAZIC A,WINTER J.The physiological role of reversible methionine oxidation[J].Biochimica et Biophysica Acta:Proteins and Proteomics,2014,1844(8):1367-1382.  

[39] HOSHI T,HEINEMANN S.Regulation of cell function by methionine oxidation and reduction[J].Journal of Physiology,2001,531(1):1-11

[40] 林厦菁,蒋守群.氨基酸对家禽免疫功能的影响及其调控机制[J].中国家禽,2014,36(11):39-43.

[41] 程传锋.蛋氨酸水平对仔猪生长性能及免疫功能的影响[D].硕士学位论文.长春:吉林农业大学,2012:67-78.

[42] 保睿,吴建新.人类神经管缺陷分子遗传学研究进展[J].中国优生与遗传杂志,2009,17(5):1-4.

[43] COELHO C N,WEBER J A,KLEIN N W,et al.Whole rat embryos require methionine for neural tube closure when cultured on cow serum[J].The Journal of Nutrition,1989,119(11):1716-1725.  

[44] COELHO C N,KLEIN N W.Methionine and neural tube closure in cultured rat embryos:morphological and biochemical analyses[J].Teratology,1990,42(4):437-451.  

[45] ESSIEN F B,WANNBERG S L.Methionine but not folinic acid or vitamin B-12 alters the frequency of neural tube defects in Axd mutant mice[J].The Journal of Nutrition,1993,123(1):27-34.  

[46] BHARGAVA S,TYAGI S C.Nutriepigenetic regulation by folate-homocysteine-methionine axis:a review[J].Molecular and Cellular Biochemistry,2014,387(1/2):55-61.

[47] KALHAN S C,BIER D M.Protein and amino acid metabolism in the human newborn[J].The Annual Review of Nutrition,2008,28(1):389-410.  

[48] 成俊萍,石德顺,陆凤花,等.氨基酸对哺乳动物胚胎体外发育的影响[J].四川畜牧兽医,2006,33(2):27-28.

[49] LEE H J,JEDRYCHOWSKI M P,VINAYAGAM A,et al.Proteomic and metabolomic characterization of a mammalian cellular transition from quiescence to proliferation[J].Cell Reports,2017,20(3):721-736.  

[50] LEE M B,KOOISTRA M,ZHANG B H,et al.Betaine homocysteine methyltransferase is active in the mouse blastocyst and promotes inner cell mass development[J].Journal of Biological Chemistry,2012,287(39):33094-33103.  

[51] 李喜艳,王加启,魏宏阳,等.MTT比色法检测赖氨酸、蛋氨酸对体外培养的奶牛乳腺上皮细胞增殖的影响[J].生物技术通报,2010(3):143-148.

[52] 于翠平.14-3-3γ对奶牛乳腺上皮细胞乳蛋白合成和细胞增殖的调节[D].博士学位论文.哈尔滨:东北农业大学,2015:67-78.

[53] MÍDIS K,COLETTA C,ASIMAKOPOULOU A,et al.Effect of S-adenosyl-l-methionine (SAM),an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro[J].Nitric Oxide,2014,41:146-156.
文章导航

/