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胃肠道褪黑素分泌及其生理功能

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  • 中国科学院亚热带农业生态研究所, 中国科学院亚热带农业生态过程重点实验室, 畜禽养殖污染控制与资源化技术国家工程实验室, 动物营养代谢过程与生理调控实验室, 长沙 410125
谭碧娥(1979-),女,湖南宁乡人,研究员,博士,主要从事仔猪营养研究。E-mail:bietan@isa.ac.cn

收稿日期: 2017-09-23

  网络出版日期: 2018-04-03

基金资助

国家自然科学基金(31330075,31301989)

Secretion and Physiological Functions of Melatonin in the Gastrointestinal Tract

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  • Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Resource Technology of Livestock And Poultry, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China

Received date: 2017-09-23

  Online published: 2018-04-03

摘要

褪黑素(N-乙酰基-5-甲氧基色胺)是调节生物节律、代谢和繁殖等的生理激素。肠道微生物以及胃肠道内分泌细胞都能合成褪黑素,褪黑素在肠道具有调节胃肠道运动和分泌、抗氧化、抗凋亡和免疫调节等作用,且在多种肠道炎症动物模型和临床研究中发挥积极的作用。本文概述褪黑素在胃肠道的合成分泌和生理功能,以及在肠道炎症疾病中的应用。

本文引用格式

谭碧娥, 任文凯, 印遇龙 . 胃肠道褪黑素分泌及其生理功能[J]. 动物营养学报, 2018 , 30(4) : 1207 -1216 . DOI: 10.3969/j.issn.1006-267x.2018.04.001

Abstract

Melatonin, N-dimethyl-5-methoxytryptamine, is a physiological hormone that regulates biorhythm, metabolism and reproduction. Melatonin can be produced by intestinal microflora and endocrine cells in the gastrointestine and regulate gastrointestinal motility and secretion, anti-oxidation, anti-apoptosis, immune function and so on, which exerting important roles in a variety of intestinal inflammatory models of animal and clinical research. The present review summarized the synthesis and physiological functions of melatonin in the gastrointestinal tract, as well as its applications of intestinal inflammatory diseases.

参考文献

[1] CHEN C Q,FICHNA J,BASHASHATI M,et al.Distribution,function and physiological role of melatonin in the lower gut[J].World Journal of Gastroenterology,2011,17(34):3888-3898.  

[2] BONNEFONT-ROUSSELOT D,COLLIN F.Melatonin:action as antioxidant and potential applications in human disease and aging[J].Toxicology,2010,278(1):55-67.  

[3] KASIMAY O,CAKIR B,DEVERSEN E,et al.Exogenous melatonin delays gastric emptying rate in rats:role of CCK2 and 5-HT3 receptors[J].Journal of Physiology and Pharmacology,2005,56(4):543-553.

[4] KIM J B,JUNG J Y,AHN J C,et al.Antioxidant and anti-apoptotic effect of melatonin on the vestibular hair cells of rat utricles[J].Clinical and Experimental Otorhinolaryngology,2009,2(1):6-12.  

[5] DOBOCOVICH M L,MANKOWSHA M.Functimal MT1 and MT2 melatonin receptors in mammals[J].Endocrine,2005,27(2):101-110.  

[6] BUBENIK G A.Localization,physiological significance and possible clinical implication of gastrointestinal melatonin[J].Biological Signals and Receptors,2001,10(6):350-366.  

[7] BERTRAND P P,BERTRAND R L,CAMELLO P J,et al.Simultaneous measurement of serotonin and melatonin from the intestine of old mice:the effects of daily melatonin supple-mentation[J].Journal of Pineal Research,2010,49(1):23-34.  

[8] MOTILVA V,CABEZA J,DE LA LASTRA C A.New issues about melatonin and its effects on the digestive system[J].Current Pharmaceutical Design,2001,7(10):909-931.  

[9] MUÑOZ-PÉREZ J L,LÓPEZ-PATIÑO M A,ÁLVAREZ-OTERO R,et al.Characterization of melatonin synthesis in the gastrointestinal tract of rainbow trout (Oncorhynchus mykiss):distribution,relation with serotonin,daily rhythms and photoperiod regulation[J].Journal of Comparative Physiology B,2016,186(4):471-484.  

[10] STEBELOVÁ K,HERICHOVÁ I,ZEMAN M.Diabetes induces changes in melatonin concentrations in peripheral tissues of rat[J].Neuro Endocrinology Letters,2007,28(2):159-165.

[11] HUETHER G.Melatonin synthesis in the gastrointestinal tract and the impact of nutritional factors on circulating melatonin[J].Annals of the New York Academy of Sciences,1994,719:146-158.

[12] TAN D X,MANCHESTER L C,ESTEBAN-ZUBERO E,et al.Melatonin as a potent and inducible endogenous antioxidant:synthesis and metabolism[J].Molecules,2015,20(10):18886-18906.  

[13] KVETNOY I M,INGEL I E,KVETNAIA T V,et al.Gastrointestinal melatonin:cellular identification and biological role[J].Neuro Endocrinology Letters,2002,23(2):121-132.

[14] YANO J M,YU K,DONALDSON G P,et al.Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis[J].Cell,2015,161(2):264-276.  

[15] LEE P P,PANG S F.Melatonin and its receptors in the gastrointestinal tract[J].Neurosignals,1993,2(4):181-193.  

[16] NOSJEAN O,FERROM,COGE F,et al.Identification of the melatonin binding site MT3 as the Quinone reductase 2[J].Journal of Biological Chemistry,2000,275(40):31311-31317.  

[17] SALLINEN P,SAARELA S,ILVES M,et al.The expression of MT1 and MT2 melatonin receptor mRNA in several rat tissues[J].Life Science,2005,76(10):1123-1134.  

[18] STEBELOVÁ K,ANTTILA K,MÄNTTÄRI S,et al.Immunohistochemical definition of MT2 receptors and melatonin in the gastrointestinal tissues of rat[J].Acta Histochemica,2010,112(1):26-33.  

[19] SÖDERQUIST F,HELLSTRÖM P M,CUNNINGHAM J L.Human gastroenteropancreatic expression of melatonin and its receptors MT1 and MT2[J].PLoS One,2015,10(3):e0120195.

[20] SOTÁK M,MRNKA L,PÁCHA J.Heterogeneous expression of melatonin receptor MT1 mRNA in the rat intestine under control and fasting conditions[J].Journal of Pineal Research,2006,41(2):183-188.  

[21] WIESENBERG I,MISSBACH M,CARLBERG C.The potential role of the transcription factor RZR/ROR as a mediator of nuclear melatonin signaling[J].Restorative Neurology and Neuroscience,1998,12(2/3):143-150.

[22] MERLE A,DELAGRANGE P,RENARD P,et al.Effect of melatonin on motility pattern of small intestine in rats and its inhibition by melatonin receptor antagonist S 22153[J].Journal of Pineal Research,2000,29(2):116-124.  

[23] DRAGO F,MACAUDA S,SALEHI S.Small doses of melatonin increase intestinal motility in rats[J].Digestive Diseases and Sciences,2002,47(9):1969-1974.  

[24] CHOJNACKI C,WALECKA-KAPICA E,LOKIE C ' K,et al.Influence of melatonin on symptoms of irritable bowel syndrome in postmenopausal women[J].Endokrynologia Polska,2013,64(2):114-120.

[25] SONG G H,LENG P H,GWEE K A,et al.Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances:a randomized,double blind,placebo controlled study[J].Gut,2005,54(10):1402-1407.  

[26] SJÖBLOM M.The duodenal mucosal bicarbonate secretion[J].Upsala Journal of Medical Sciences,2005,110(2):115-149.  

[27] REITER R J.Melatonin:lowering the high price of free radicals[J].News in Physiological Sciences,2000,15(5):246-250.

[28] REITER R J,PAREDES S D,MANCHESTER L C,et al.Reducing oxidative/nitrosative stress:a newly-discovered genre for melatonin[J].Critical Reviews in Biochemistry and Molecular Biology,2009,44(4):175-200.  

[29] TAN D X,REITER R J,MANCHESTER L C,et al.Chemical and physical properties and potential mechanisms:melatonin as a broad spectrum antioxidant and free radical scavenger[J].Current Topics in Medicinal Chemistry,2002,2(2):181-197.  

[30] ESPOSITO E,CUZZOCREA S.Antiinflammatory activity of melatonin in central nervous system[J].Current Neuropharmacology,2010,8(3):228-242.  

[31] MEI Q,DIAO L,XU J M,et al.A protective effect of melatonin on intestinal permeability is induced by diclofenac via regulation of mitochondrial function in mice[J].Acta Pharmacologica Sinica,2011,32(4):495-502.  

[32] REITER R J,ROSALES-CORRAL S,TAN D X,et al.Melatonin as a mitochondria-targeted antioxidant:one of evolution's best ideas[J].Cellular and Molecular Life Sciences,2017,74(21):3863-3881.  

[33] TAMURA E K,SILVA C L M,MARKUS R P.Melatonin inhibits endothelial nitric oxide production in vitro[J].Journal of Pineal Research,2006,41(3):267-274.  

[34] BRAZÃO V,DEL VECCHIO FILIPIN M,SANTELLO F H,et al.Immunomodulatory properties and anti-apoptotic effects of zinc and melatonin in an experimental model of chronic Chagas disease[J].Immunobiology,2015,220(5):626-633.  

[35] CHETSAWANG B,PUTTHAPRASART C,PHANSUWAN-PUJITO P,et al.Melatonin protects against hydrogen peroxide-induced cell death signaling in SH-SY5Y cultured cells:involvement of nuclear factor kappa B,Bax and Bcl-2[J].Journal of Pineal Research,2006,41(2):116-123.  

[36] GUHA M,MAITY P,CHOUBEY V,et al.Melatonin inhibits free radical-mediated mitochondrial-dependent hepatocyteapoptosis and liver damage induced during malarial infection[J].Journal of Pineal Research,2007,43(4):372-381.  

[37] KIM C H,KIM K H,YOO Y M.Melatonin protects against apoptotic and autophagic cell death in C2C12 murine myoblast cells[J].Journal of Pineal Research,2011,50(3):241-249.  

[38] ANDRABI S A,SAYEED I,SIEMEN D,et al.Direct inhibition of the mitochondrial permeability transition pore:a possible mechanism responsible for anti-apoptotic effects of melatonin[J].FASEB Journal,2004,18(7):869-871.  

[39] REN W K,LIU G,CHEN S,et al.Melatonin signaling in T cells:functions and applications[J].Journal of Pineal Research,2017,62(3):e12394.

[40] HALDAR C,RAI S,SINGH R.Melatonin blocks dexamethasone-induced immunosuppression in a seasonally breeding rodent Indian palm squirrel,Funambulus pennanti[J].Steroids,2004,69(6):367-377.  

[41] CAPELLI E,CAMPO I,PANELLI S,et al.Evaluation of gene expression in human lymphocytes activated in the presence of melatonin[J].International Immunopharmacology,2002,2(7):885-892.  

[42] MUXEL S M,PIRES-LAPA M A,MONTEIRO A W,et al.NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene[J].PLoS One,2012,7(12):e52010.

[43] RAGHAVENDRA V,SINGH V,KULKARNI S K,et al.Melatonin enhances Th2 cell mediated immune responses:lack of sensitivity to reversal by naltrexone or benzodiazepine receptor antagonists[J].Molecular and Cellular Biochemistry,2001,221(1/2):57-62.  

[44] YU Q N,MILLER S C,OSMOND D G.Melatonin inhibits apoptosis during early B-cell development in mouse bone marrow[J].Journal of Pineal Research,2000,29(2):86-93.  

[45] CARRILLO-VICO A,LARDONE P J,ÁLVAREZ-SÁNCHEZ N,et al.Melatonin:buffering the immune system[J].International Journal of Molecular Sciences,2013,14(4):8638-8683.  

[46] TIAN Y M,ZHANG G Y,DAI Y R.Melatonin rejuvenates degenerated thymus and redresses peripheral immune functions in aged mice[J].Immunology Letters,2003,88(2):101-104.  

[47] LIU F,NG T B,FUNG M C.Pineal indoles stimulate the gene expression of immunomodulating cytokines[J].Journal of Neural Transmission,2001,108(4):397-405.  

[48] CURRIER N L,SUN L Z Y,MILLER S C.Exogenous melatonin:quantitative enhancement in vivo of cells mediating non-specific immunity[J].Journal of Neuroimmunology,2000,104(2):101-108.  

[49] SANTELLO F H,FRARE E O,DOS SANTOS C D,et al.Suppressive action of melatonin on the TH-2 immune response in rats infected with Trypanosoma cruzi[J].Journal of Pineal Research,2008,45(3):291-296.  

[50] BRAZÃO V,DEL VECCHIO FILIPIN M,SANTELLO F H,et al.Melatonin and zinc treatment:distinctive modulation of cytokine production in chronic experimental Trypanosoma cruzi infection[J].Cytokine,2011,56(3):627-632.  

[51] POHANKA M.Impact of melatonin on immunity:a review[J].Central European Journal of Medicine,2013,8(4):369-376.

[52] CARRILLO-VICO A,LARDONE P J,FERNÁNDEZ-SANTOS J M,et al.Human lymphocyte-synthesized melatonin is involved in the regulation of the interleukin-2/interleukin-2 receptor system[J].Journal of Clinical Endocrinology and Metabolism,2005,90(2):992-1000.  

[53] CHEN Y,ZHANG J,ZHAO Q,et al.Melatonin induces anti-inflammatory effects to play a protective role via endoplasmic reticulum stress in acute pancreatitis[J].Cellular Physiology and Biochemistry,2016,40(5):1094-1104.  

[54] DONG W G,MEI Q,YU J P,et al.Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis[J].World Journal of Gastroenterology,2003,9(6):1307-1311.  

[55] ESPOSITO E,MAZZON E,RICCARDI L,et al.Matrix metalloproteinase-9 and metalloproteinase-2 activity and expression is reduced by melatonin during experimental colitis[J].Journal of Pineal Research,2008,45(2):166-173.  

[56] LI J H,YU J P,YU H G,et al.Melatonin reduces inflammatory injury through inhibiting NF-κB activation in rats with colitis[J].Mediators of Inflammation,2005,2005(4):185-193.  

[57] MAHMOOD N M A,JUMMA K M,HUSSAIN S A.Dose-dependent anti-inflammatory activity of melatonin in experimental animal model of chronic inflammation[J].Global Journal of Pharmacology,2010,4(2):66-70.

[58] MOZAFFARI S,ABDOLLAHI M.Melatonin,a promising supplement in inflammatory bowel disease:a comprehensive review of evidences[J].Current Pharmaceutical Design,2011,17(38):4372-4378.  

[59] NOSÁL'OVÁ V,ZEMAN M, ?ERNÁ S,et al.Protective effect of melatonin in acetic acid induced colitis in rats[J].Journal of Pineal Research,2007,42(4):364-370.  

[60] TRIANTAFILLIDIS A,TRIANTAFILLIDIS J K.Melatonin:a potent antioxidant agent with anti-inflammatory and anti-apoptotic effects that might be useful in the treatment of IBD patients[J].Annals of Gastroenterology,2009,22(1):10-12.

[61] GITTO E,MARSEGLIA L,MANTI S,et al.Protective role of melatonin in neonatal diseases[J].Oxidative Medicine and Cellular Longevity,2013,2013:980374.

[62] MAURIZ J L,COLLADO P S,VENEROSO C,et al.A review of the molecular aspects of melatonin's anti-inflammatory actions:recent insights and new perspectives[J].Journal of Pineal Research,2013,54(1):1-14.  

[63] YU G M,KUBOTA H,OKITA M,et al.The anti-inflammatory and antioxidant effects of melatonin on LPS-stimulated bovine mammary epithelial cells[J].PLoS One,2017,12(5):e0178525.

[64] MEI Q,YU J P,XU J M,et al.Melatonin reduces colon immunological injury in rats by regulating activity of macrophages[J].Acta Pharmacologica Sinica,2002,23(10):882-886.

[65] MAZZON E,ESPOSITO E,CRISAFULLI C,et al.Melatonin modulates signal transduction pathways and apoptosis in experimental colitis[J].Journal of Pineal Research,2006,41(4):363-373.  

[66] SUN X C,SHAO Y Y,JIN Y,et al.Melatonin reduces bacterial translocation by preventing damage to the intestinal mucosa in an experimental severe acute pancreatitis rat model[J].Experimental and Therapeutic Medicine,2013,6(6):1343-1349.  

[67] LIU T,ZHANG L Y,JOO D,et al.NF-κB signaling in inflammation[J].Signal Transduction and Targeted Therapy,2017,2:17023.

[68] XU P,WANG J,HONG F,et al.Melatonin prevents obesity through modulation of gut microbiota in mice[J].Journal of Pineal Research,2017,62(4):e12399.

[69] REN W K,WANG P,YAN J M,et al.Melatonin alleviates weanling stress in mice:involvement of intestinal microbiota[J].Journal of Pineal Research,2017,doi:10.1111/jpi.12448.

[70] ANDERSON G,MAES M.The gut-brain axis:the role of melatonin in linking psychiatric,inflammatory and neurodegenerative conditions[J].Advances in Integrative Medicine,2015,2(1):31-37.  
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