吕小康, 王杰, 刁其玉, 张乃锋 . 过氧化物酶体增殖物激活受体调控幼龄反刍动物瘤胃的生酮作用及其机制[J]. 动物营养学报, 2018 , 30(4) : 1238 -1244 . DOI: 10.3969/j.issn.1006-267x.2018.04.005

[1] 胡越,许军,刘燕华,等.PPARα激动剂降血脂作用的研究进展[J].中国药科大学学报,2016,47(1):118-124.

[2] 金鹏,陈保林,杨永曜.PPARα/PGC-1α信号通路对阿霉素损伤h9c2心肌细胞能量代谢的调节[J].临床心血管病杂志,2016,32(4):388-391.

[3] NAEEM A.Effect of age and dietary plane of nutrition on transcript profiles of ruminal tissue of Holstein bull calves[D].Ph.D.Thesis.Urbana:University of Illinois at Urbana-Champaign,2012.

[4] WANG W M,CHONG L,LI F D,et al.Effects of early feeding on the host rumen transcriptome and bacterial diversity in lambs[J].Scientific Reports,2016,6:32479.

[5] KINOSHITA M,SUZUKI Y,SAITO Y.Butyrate reduces colonic paracellular permeability by enhancing PPARγ activation[J].Biochemical and Biophysical Research Communications,2002,293(2):827-831.  

[6] WANG L J,CHEN L,TAN Y Z,et al.Betaine supplement alleviates hepatic triglyceride accumulation of apolipoprotein E deficient mice via reducing methylation of peroxisomal proliferator-activated receptor alpha promoter[J].Lipids in Health and Disease,2013,12(1):34.

[7] JIAO J Z,LI X P,BEAUCHEMIN K A,et al.Rumen development process in goats as affected by supplemental feeding v.Grazing:age-related anatomic development,functional achievement and microbial colonisation[J].British Journal of Nutrition,2015,113(6):888-900.  

[8] GEORGIADI A,KERSTEN S.Mechanisms of gene regulation by fatty acids[J].Advances in Nutrition,2012,3(2):127-134.  

[9] 林圣宸.核受体PPARs家族与新型激动剂的结构与功能研究[D].博士学位论文.厦门:厦门大学,2013.

[10] WAKU T,SHIRAKI T,OYAMA T,et al.Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids[J].Journal of Molecular Biology,2009,385(1):188-199.  

[11] FERRÉ P.The biology of peroxisome proliferator-activated receptors:Relationship with lipid metabolism and insulin sensitivity[J].Diabetes,2004,53(1S):43-50.

[12] 杨亚维,袁杰.PPARα抗氧化应激作用的研究进展[J].东南大学学报(医学版),2016,35(1):147-150.

[13] NAEEM A,DRACKLEY J K,STAMEY J,et al.Role of metabolic and cellular proliferation genes in ruminal development in response to enhanced plane of nutrition in neonatal Holstein calves[J].Journal of Dairy Science,2012,95(4):1807-1820.  

[14] COLLET N,THÉOLEYRE S,RAGEUL J,et al.PPARγ is functionally expressed in clear cell renal cell carcinoma[J].International Journal of Oncology,2011,38(3):851-857.

[15] BIONAZ M,CHEN S W,KHAN M J,et al.Functional role of PPARs in ruminants:potential targets for fine-tuning metabolism during growth and lactation[J].PPAR Research,2013,2013:684159.

[16] PYPER S R,NAVIN V,YU S T,et al.PPARα:energy combustion,hypolipidemia,inflammation and cancer[J].Nuclear Receptor Signaling,2010,8:e002.

[17] 王丽,那威,王宇祥,等.鸡PPARγ基因的表达特性及其对脂肪细胞增殖分化的影响[J].遗传,2012,34(4):454-464.

[18] CAPPON G D,LIU R C M,FRAME S R,et al.Effects of the rat hepatic peroxisome proliferator,wyeth 14,643,on the lactating goat[J].Drug and Chemical Toxicology,2002,25(3):255-266.  

[19] SCHLEGEL G,KELLER J,HIRCHE F,et al.Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation[J].BMC Veterinary Research,2012,8:28.

[20] BRENNAN K M,MICHAL J J,RAMSEY J J,et al.Body weight loss in beef cows:Ⅰ.The effect of increased β-oxidation on messenger ribonucleic acid levels of uncoupling proteins two and three and peroxisome proliferator-activated receptor in skeletal muscle[J].Journal of Animal Science,2009,87(9):2860-2866.  

[21] GARCÍA-ROJAS P,ANTARAMIAN A,GONZÁLEZ-DÁVALOS L,et al.Induction of peroxisomal proliferator-activated receptor gamma and peroxisomal proliferator-activated receptor gamma coactivator 1 by unsaturated fatty acids,retinoic acid,and carotenoids in preadipocytes obtained from bovine white adipose tissue[J].Journal of Animal Science,2010,88(5):1801-1808.  

[22] SHARMA S,SUN X T,RAFIKOV R,et al.PPAR-gamma regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow[J].PLoS One,2012,7(9):e41555.

[23] PENNER G B,STEELE M A,ASCHENBACH J R,et al.Ruminant Nutrition Symposium:Molecular adaptation of ruminal epithelia to highly fermentable diets[J].Journal of Animal Science,2011,89(4):1108-1119.  

[24] CONNOR E E,BALDWIN R L,WALKER M P,et al.Transcriptional regulators transforming growth factor-β1 and estrogen-related receptor-α identified as putative mediators of calf rumen epithelial tissue development and function during weaning[J].Journal of Dairy Science,2014,97(7):4193-4207.  

[25] LIN Z F,PAN X B,WU F,et al.Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice[J].Circulation,2015,131(21):1861-1871.  

[26] OKINE B N,SPICER C,MILLNS P,et al.Systemic administration of WY-14643,a selective synthetic agonist of peroxisome proliferator activator receptor-alpha,alters spinal neuronal firing in a rodent model of neuropathic pain[J].Scandinavian Journal of Pain,2015,9:42-48.

[27] 沈桂佳,安鹏,聂玉强,等.PPAR-β/δ及其激动剂l165041对小鼠肝脏成瘤的影响[J].胃肠病学和肝病学杂志,2015,24(11):1350-1353.

[28] HARMS M,SEALE P.Brown and beige fat:development,function and therapeutic potential[J].Nature Medicine,2013,19(10):1252-1263.  

[29] RUBY M A,GOLDENSON B,ORASANU G,et al.VLDL hydrolysis by LPL activates PPAR-α through generation of unbound fatty acids[J].Journal of Lipid Research,2010,51(8):2275-2281.  

[30] DENGLER F,RACKWITZ R,BENESCH F,et al.Both butyrate incubation and hypoxia upregulate genes involved in the ruminal transport of SCFA and their metabolites[J].Journal of Animal Physiology and Animal Nutrition,2015,99(2):379-390.  

[31] KHAN S A,HEUVEL J P V.Reviews:current topicsrole of nuclear receptors in the regulation of gene expression by dietary fatty acids (review)[J].Journal of Nutritional Biochemistry,2003,14(10):554-567.  

[32] HUSS J M,TORRA I P,STAELS B,et al.Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle[J].Molecular & Cellular Biology,2004,24(20):9079-9091.  

[33] SHAO D,LIU Y,LIU X J,et al.PGC-1β-Regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERRα[J].Mitochondrion,2010,10(5):516-527.  

[34] 丁勇,许超,吴季辉,等.表观遗传学研究进展[J].中国科学(生命科学),2017,47(1):3-15.

[35] 唐丹,周永健,李瑜元,等.姜黄素对脂肪变性肝细胞过氧化物酶体增殖物活化受体-α的去甲基化作用[J].广东医学,2014,35(2):175-179.

[36] KIRCHNER H,SINHA I,GAO H,et al.Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients[J].Molecular Metabolism,2016,5(3):171-183.  

[37] OHASHI K,MUNETSUNA E,YAMADA H,et al.High fructose consumption induces DNA methylation at PPARα and CPT1A promoter regions in the rat liver[J].Biochemical & Biophysical Research Communications,2015,468(1/2):185-189.

[38] OSORIO J S,JACOMETO C B,ZHOU Z,et al.Hepatic global DNA and peroxisome proliferator-activated receptor alpha promoter methylation are altered in peripartal dairy cows fed rumen-protected methionine[J].Journal of Dairy Science,2016,99(1):234-244.  

[39] 王洁,张心怡,郝彩丽,等.组蛋白去乙酰化酶抑制剂的研究进展[J].现代生物医学进展,2014,14(14):2783-2785.

[40] MYZAK M C,DASHWOOD R H.Histone deacetylases as targets for dietary cancer preventive agents:Lessons learned with butyrate,diallyl disulfide,and sulforaphane[J].Current Drug Targets,2006,7(4):443-452.