动物营养学报 >

2018 , Vol. 30 >Issue 4: 1471 - 1480

DOI: https://doi.org/10.3969/j.issn.1006-267x.2018.04.031

饲料营养 Feed science and technology

凹土纳米氧化锌对断奶仔猪生长性能、器官指数及血液生化指标的影响

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  • 1. 扬州大学动物科学与技术学院, 扬州 225009;
    2. 溧阳市动物疫病预防控制中心, 常州 213300
毛俊舟(1993-),男,安徽六安人,硕士研究生,从事单胃动物营养研究。E-mail:781446817@qq.com

收稿日期: 2017-09-30

  网络出版日期: 2018-04-03

基金资助

江苏省高校研究生创新工程项目（XSJCX17-035）；扬州大学镇江高新技术研究院开放课题（02）；扬州市自然科学基金（青年）（YZ2016115）；扬州市产学研合作专项（市校合作）（YZ2016257）；江苏省基础研究计划（自然科学基金）青年基金项目（BK20170490）；江苏现代农业（生猪）产业技术体系海门推广示范基地项目[SXGC（2017）085]；江苏省苏北发展计划（BN2015073，BN2016095）

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Effects of Attapulgite Nano Zinc Oxide on Growth Performance, Organ Indices and Blood Biochemical Indices of Weaned Piglets

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  • 1. College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China;
    2. Animal Disease Prevention and Control Center of Liyang, Changzhou 213300, China

Received date: 2017-09-30

  Online published: 2018-04-03

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摘要

本试验旨在研究饲粮中添加凹凸棒土负载纳米氧化锌（凹土纳米氧化锌）对断奶仔猪生长性能、器官指数及血液生化指标的影响。试验选取210头21日龄体重相近[（6.30±0.51）kg]的健康杜×长×大断奶仔猪，随机分为7组，每组6个重复，每个重复5头猪。对照组（CON组）饲喂基础饲粮，抗生素组（ANT组）饲喂基础饲粮+100 mg/kg 50%喹乙醇+150 mg/kg 15%金霉素+50 mg/kg 10%硫酸黏菌素，氧化锌组（ZO组）饲喂基础饲粮+3 000 mg/kg氧化锌，纳米氧化锌组（NZO组）饲喂基础饲粮+800 mg/kg纳米氧化锌，低凹土纳米氧化锌组（LA-ZO组）饲喂基础饲粮+700 mg/kg凹土纳米氧化锌，中凹土纳米氧化锌组（MA-ZO组）饲喂基础饲粮+1 000 mg/kg凹土纳米氧化锌，高凹土纳米氧化锌组（HA-ZO组）饲喂基础饲粮+1 300 mg/kg凹土纳米氧化锌。试验预试期3 d，正试期9 d。结果表明：1）与CON组相比，饲粮添加凹土纳米氧化锌显著提高断奶仔猪平均日采食量和平均日增重（P<0.05）。2）LA-ZO组腹泻率与CON组、ANT组相比显著降低（P<0.05），LA-ZO组腹泻指数相比于CON组、ANT组和NZO组均显著降低（P<0.05）。3）LA-ZO组和MA-ZO组胰腺指数与NZO组相比显著提高（P<0.05）。4）与CON组相比，MA-ZO组血液总胆固醇（TC）和甘油三脂（TG）含量显著降低（P<0.05），血液高密度脂蛋白（HDL）含量显著提高（P<0.05），且显著高于ANT组和NZO组（P<0.05）；HA-ZO组血液HDL含量显著高于CON组和ANT组（P<0.05）。结果显示，在断奶仔猪饲粮中添加凹土纳米氧化锌可提高仔猪生长性能，降低腹泻率，改善仔猪生长发育，同时可降低血液TG和TC含量，提高血液HDL含量，加强脂代谢和胰腺发育，可替代抗生素和高锌的使用。

关键词： 凹土纳米氧化锌; 断奶仔猪; 生长性能; 器官指数; 血液生化指标

本文引用格式

毛俊舟, 董丽, 王淑楠, 彭众, 仲召鑫, 屈国敏, 喻礼怀 . 凹土纳米氧化锌对断奶仔猪生长性能、器官指数及血液生化指标的影响[J]. 动物营养学报, 2018 , 30(4) : 1471 -1480 . DOI: 10.3969/j.issn.1006-267x.2018.04.031

Abstract

The experiment was conducted to explore the effects of attapulgite nano zinc oxide on the growth performance, organ indices and blood biochemical indices of weaned piglets. A total of 210 Duroc×Landrace×Yorkshire piglets with 21-day-old and similar body weight of (6.30±0.51) kg were randomly allocated into 7 groups with 6 replicates each and 5 pigs in each replicate. Pigs in the control group (CON group) were fed a basal diet, in antibiotic group (ANT group) were fed a basal diet supplemented with 100 mg/kg 50% olaquindox, 150 mg/kg 15% chlortetracycline and 50 mg/kg 10% sulfate colistin, and in the other groups were fed the basal diet supplemented with 3 000 mg/kg zinc oxide (ZO group), 800 mg/kg nano-zinc oxide (NZO group), and 700, 1 000 and 1 300 mg/kg attapulgite nano zinc oxide (LA-ZO group, MA-ZO group and HA-ZO group), respectively. The experiment lasted for 9 days after 3 days adaption. The results showed as follows:1) compared with CON group, dietary attapulgite nano zinc oxide significantly increased the average daily feed intake and average daily gain of weaned piglets (P<0.05). 2) Compared with CON group and ANT group, the diarrhea rate in LA-ZO group was significantly decreased (P<0.05). The diarrhea index in LA-ZO group was significantly lower than that in CON group, ANT group and NZO group (P<0.05). 3) The pancreas index in LA-ZO group and MA-ZO group was significantly higher than that in NZO group (P<0.05). 4) Compared with CON group, the contents of blood total cholesterol (TC) and triglyceride (TG) in MA-ZO group was significantly decreased (P<0.05), and the blood high density lipoprotein content in MA-ZO group was significantly increased (P<0.05), which was significantly higher than that in ANT group and NZO group (P<0.05). The blood high density lipoprotein content in HA-ZO group was significantly higher than that in CON group and ANT group (P<0.05). The results indicate that dietary attapulgite nano-zinc oxide can improve the growth performance, decrease the diarrhea rate, and promote the growth and development of weaned piglets, meanwhile decrease the contents of TG and TC in blood, increase blood high density lipoprotein content, strengthen lipid metabolism and pancreas development. Thus, it has potential to replace the utilization of antibiotics and high zinc for weaned piglets.

Key words： attapulgite nano zinc oxide; weaned piglets; growth performance; organ index; blood biochemical index

参考文献

[1] HU C H,SONG J,YOU Z T,et al.Zinc oxide-montmorillonite hybrid influences diarrhea,intestinal mucosal integrity,and digestive enzyme activity in weaned pigs[J].Biological Trace Element Research,2012,149(2):190-196.  

[2] HOFER U.Microbiome:effects of in-feed antibiotics on pig microbiota[J].Nature Reviews Microbiology,2014,12(4):234-234.

[3] BARTON M D.Antibiotic use in animal feed and its impact on human health[J].Nutrition Research Reviews,2000,13(2):279-299.  

[4] SAHOO A,SWAIN R K,MISHRA S K.Effect of inorganic,organic and nano zinc supplemented diets on bioavailability and immunity status of broilers[J].International Journal of Advanced Research,2014,2(11):828-837.

[5] SWAIN P S,RAJENDRAN D,RAO S B N,et al.Preparation and effects of nano mineral particle feeding in livestock:a review[J].Veterinary World,2015,8(7):888-891.  

[6] 田丽娜,姜建阳,朱风华,等.纳米氧化锌对肉鸡生长性能和屠宰性能的影响[J].中国农学通报,2009,25(2):1-5.

[7] MISHRA A,SWAIN R K,MISHRA S K,et al.Growth performance and serum biochemical parameters as affected by nano zinc supplementation in layer chicks[J].Indian Journal of Animal Nutrition,2014,31(4):384-388.

[8] SAHOO A,SWAIN R K,MISHRA S K,et al.Serum biochemical indices of broiler birds fed on inorganic,organic and nano zinc supplemented diets[J].International Journal of Recent Scientific Research,2014,5(11):2078-2081.

[9] ZHAO C Y,TAN S X,XIAO X Y,et al.Effects of dietary zinc oxide nanoparticles on growth performance and antioxidative status in broilers[J].Biological Trace Element Research,2014,160(3):361-367.  

[10] LONG L N,CHEN J S,ZHANG Y G,et al.Comparison of porous and nano zinc oxide for replacing high-dose dietary regular zinc oxide in weaning piglets[J].PLoS One,2017,12(8):e0182550.

[11] SWAIN P S,RAO S B N,RAJENDRAN D,et al.Nano zinc,an alternative to conventional zinc as animal feed supplement:a review[J].Animal Nutrition,2016,2(3):134-141.  

[12] WANG B,FENG W Y,WANG M,et al.Acute toxicological impact of nano-and submicro-scaled zinc oxide powder on healthy adult mice[J].Journal of Nanoparticle Research,2008,10(2):263-276.  

[13] CHEN H,WANG A Q.Kinetic and isothermal studies of lead ion adsorption onto palygorskite clay[J].Journal of Colloid and Interface Science,2007,307(2):309-316.  

[14] WANG W B,TIAN G Y,ZHANG Z F,et al.A simple hydrothermal approach to modify palygorskite for high-efficient adsorption of methylene blue and Cu(Ⅱ) ions[J].Chemical Engineering Journal,2015,265:228-238.

[15] ZHOU S Y,XUE A L,ZHANG Y,et al.Novel polyamidoamine dendrimer-functionalized palygorskite adsorbents with high adsorption capacity for Pb2+ and reactive dyes[J].Applied Clay Science,2015,107:220-229.

[16] BERHANE T M,LEVY J,KREKELER M P S,et al.Adsorption of bisphenol A and ciprofloxacin by palygorskite-montmorillonite:effect of granule size,solution chemistry and temperature[J].Applied Clay Science,2016,132-133:518-527.

[17] MONTE M B M,MIDDEA A,PAIVA P R P,et al.Nutrient release by a Brazilian sedimentary zeolite[J].Anais da Academia Brasileira de Ciências,2009,81(4):641-653.  

[18] RAHIMI M,MOBEDI H,BEHNAMGHADER A,et al.Fat-soluble vitamins release based on clinoptilolite zeolite as an oral drug delivery system[J].Letters in Drug Design & Discovery,2012,9(2):213-217.  

[19] THE EUROPEAN COMMISSION.Commission regulation (EU) 575/2011 of 16 June 2011 on the catalogue of feed materials[J].Official Journal of the European Union,2011,159:25-65.

[20] ZHANG J M,LV Y F,TANG C H,et al.Effects of dietary supplementation with palygorskite on intestinal integrity in weaned piglets[J].Applied Clay Science,2013,86:185-189.

[21] TANG C H,WANG X Q,ZHANG J M.Effects of supplemental palygorskite instead of zinc oxide on growth performance,apparent nutrient digestibility and fecal zinc excretion in weaned piglets[J].Animal Science Journal,2014,85(4):435-439.  

[22] LV Y F,TANG C H,WANG X Q,et al.Effects of dietary supplementation with palygorskite on nutrient utilization in weaned piglets[J].Livestock Science,2015,174:82-86.

[23] ZHANG L,YAN R,ZHANG R Q,et al.Effect of different levels of palygorskite inclusion on pellet quality,growth performance and nutrient utilization in broilers[J].Animal Feed Science and Technology,2017,223:73-81.

[24] CASTILLO M,MARTÍN-OR ÚE S M,TAYLOR-PICKARD J A,et al.Use of mannan-oligosaccharides and zinc chelate as growth promoters and diarrhea preventative in weaning pigs:effects on microbiota and gut function[J].Journal of Animal Science,2008,86(1):94-101.  

[25] DUNSHEA F R.Sexual dimorphism in growth of sucking and growing pigs[J].Asian-Australasian Journal of Animal Sciences,2001,14(11):1610-1615.  

[26] SPREEUWENBERG M A M,VERDONK J,GASKINS H R,et al.Small intestine epithelial barrier function is compromised in pigs with low feed intake at weaning[J].The Journal of Nutrition,2001,131(5):1520-1527.  

[27] WANG C,ZHANG L G,SU W P,et al.Zinc oxide nanoparticles as a substitute for zinc oxide or colistin sulfate:Effects on growth,serum enzymes,zinc deposition,intestinal morphology and epithelial barrier in weaned piglets[J].PLoS One,2017,12(7):e0181136.

[28] 孟艳莉.凹凸棒石、蒙脱石及其复合物对断奶仔猪肠道的保护作用研究[D].硕士学位论文.北京:中国农业科学院,2011.

[29] 罗友文,周岩民,王恬.凹凸棒石粘土的生物学功能及其在动物生产上的应用[J].硅酸盐通报.2006,25(6):159-164.

[30] 肖金松,罗有文.凹凸棒石黏土在动物生产上的应用及其作用机制[J].江西农业学报,2008,20(10):97-99.

[31] 韩萌.纳米氧化锌对断奶仔猪肠道菌群平衡及黏膜免疫的影响[D].硕士学位论文.北京:中国农业大学,2017.

[32] LI Y,GUO W,HAN S S,et al.The evolution of the gut microbiota in the giant and the red pandas[J].Scientific Reports,2015,5:10185.

[33] KATOULI M,MELIN L,JENSEN-WAERN M,et al.The effect of zinc oxide supplementation on the stability of the intestinal flora with special reference to composition of coliforms in weaned pigs[J].Journal of Applied Microbiology,1999,87(4):564-573.  

[34] 红玮,王贺,童春晖.具有药用前景的天然矿物——凹凸棒石[J].药学进展,2005,29(1):43-45.

[35] ROUSSEL A J,Jr,BRUMBAUGH G W.Treatment of diarrhea of neonatal calves[J].Veterinary Clinics of North America:Food Animal Practice,1991,7(3):713-728.  

[36] ARABI F,IMANDAR M,NEGAHDARY M,et al.Investigation anti-bacterial effect of zinc oxide nanoparticles upon life of Listeria monocytogenes[J].Annals of Biological Research,2012,3(7):3679-3685.

[37] 梁晓维,李发弟,张军民,等.蒙脱石和凹凸棒石对霉菌毒素吸附性能的研究[J].中国畜牧兽医,2014,41(11):133-138.

[38] 黄强,徐稳,王恬,等.日粮补充亮氨酸对超早期断奶宫内发育迟缓仔猪内源消化酶活性及胰腺抗氧化能力的影响[J].南京农业大学学报,2017,40(1):123-129.

[39] ZIMMERMANN R,STRAUSS J G,HAEMMERLE G,et al.Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase[J].Science,2004,306(5700):1383-1386.  

[40] DUKES H H.The physiology of domestic animals[M].New York:Comstock Publishing Associates,1955.

[41] 徐奇友,刘立波,侯奉雨,等.纳米氧化锌对肉仔鸡血清生化指标的影响[J].动物营养学报,2007,19(1):76-80.

[42] TOTH P P,DAVIDSON M H.Therapeutic interventions targeted at the augmentation of reverse cholesterol transport[J].Current Opinion in Cardiology,2004,19(4):374-379.  

[43] 王彬,刘路杰,祝佳,等.纳米氧化锌对断奶仔猪生长性能、血清免疫和生化指标的影响[J].动物营养学报,2016,28(11):3626-3633.
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