综述 Review

丁酸梭菌在畜禽生产中的应用研究进展

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  • 1. 扬州大学动物科学与技术学院, 扬州 225009;
    2. 镇江市动物疫病预防控制中心, 镇江 212009;
    3. 东台市畜牧兽医站, 东台 224200
赵敏孟(1988-),男,山东泰安人,博士,从事动物营养生理调控的研究。E-mail:zhaominmeng123@163.com

收稿日期: 2018-01-11

  网络出版日期: 2018-07-20

基金资助

江苏省苏北科技专项(BN2016086);江苏省农业三新工程项目(SXGC[2017]154);扬州市科技计划项目(YZ2016055);镇江市1+1+N农业推广项目

Research Progress on Application of Clostridium butyricum in Livestock and Poultry Production

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  • 1. College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China;
    2. Zhenjiang Animal Disease Prevention and Control Center, Zhenjiang 212009, China;
    3. Animal Husbandry and Veterinary Station of Dongtai, Dongtai 224200, China

Received date: 2018-01-11

  Online published: 2018-07-20

摘要

丁酸梭菌(Clostridium butyricum)具有调节肠道微生态平衡、产生消化酶和维生素等营养物质、提高动物免疫力、抗细胞凋亡、抗肿瘤等多种生理功能。此外,丁酸梭菌属于厌氧芽孢杆菌,对饲料加工过程中的高温、高压以及动物胃肠道环境有较好的耐受性。因此,丁酸梭菌是一种适合在畜禽生产中添加的益生菌。本文总结了丁酸梭菌的生物学特性、生理功能和对畜禽生产的影响及其作用机理,为丁酸梭菌的进一步研究和开发应用提供参考。

本文引用格式

赵敏孟, 单昊书, 沈永华, 张程, 刘龙, 龚道清 . 丁酸梭菌在畜禽生产中的应用研究进展[J]. 动物营养学报, 2018 , 30(7) : 2467 -2472 . DOI: 10.3969/j.issn.1006-267x.2018.07.005

Abstract

Clostridium butyricum has a lot of properties such as maintaining the intestinal microecological balance, producing digestive enzymes and vitamins, improving immunity, anti-apoptosis and anti-cancer. Furthermore, Clostridium butyricum belongs to anaerobic bacillus and can tolerate the high temperature and high pressure in feed processing, as well as the gastrointestinal environment. Therefore, the Clostridium butyricum can be used as an ideal probiotic feed additive. This paper summarizes the biological characteristics, physiological functions, the effects and mechanism of Clostridium butyricum on livestock and poultry production. These will provide references for further research and exploitation of Clostridium butyricum.

参考文献

[1] OELSCHLAEGER T A.Mechanisms of probiotic actions-a review[J].International Journal of Medical Microbiology,2010,300(1):57-62.  

[2] DUAN Y F,ZHANG Y,DONG H B,et al.Effect of the dietary probiotic Clostridium butyricum on growth,intestine antioxidant capacity and resistance to high temperature stress in kuruma shrimp Marsupenaeus japonicus[J].Journal of Thermal Biology,2017,66:93-100.

[3] 贾丽楠,崔嘉,陈宝江.丁酸梭菌对肉仔鸡饲料加工过程及消化道环境的耐受性研究[J].动物营养学报,2017,29(10):3787-3791.

[4] 刘磊,田亚男,倪学勤,等.丁酸梭菌CBM01的碳、氮源优化及其对胃肠道耐受性的研究[J].动物营养学报,2017,29(10):3831-3836.

[5] CAO G T,XIAO Y P,YANG C M,et al.Effects of Clostridium butyricum on growth performance,nitrogen metabolism,intestinal morphology and cecal microflora in broiler chickens[J].Journal of Animal and Veterinary Advances,2012,11(15):2665-2671.  

[6] ZHANG L,ZHANG L L,ZENG X A,et al.Effects of dietary supplementation of probiotic,Clostridium butyricum,on growth performance,immune response,intestinal barrier function,and digestive enzyme activity in broiler chickens challenged with Escherichia coli K88[J].Journal of Animal Science and Biotechnology,2016,7:3.

[7] ARAKI Y,ANDOH A,FUJIYAMA Y,et al.Oral administration of a product derived from Clostridium butyricum in rats[J].International Journal of Molecular Medicine,2002,9(1):53-57.

[8] SUN J,LING Z X,WANG F Y,et al.Clostridium butyricum pretreatment attenuates cerebral ischemia/reperfusion injury in mice via anti-oxidation and anti-apoptosis[J].Neuroscience Letters,2016,613:30-35.

[9] HOSSAIN M M,BEGUM M,KIM I H.Effect of Bacillus subtilis, Clostridium butyricum and Lactobacillus acidophilus endospores on growth performance,nutrient digestibility,meat quality,relative organ weight,microbial shedding and excreta noxious gas emission in broilers[J].Veterinární Medicína,2015,60(2):77-86.  

[10] 贾聪慧,杨彩梅,曾新福,等.丁酸梭菌对肉鸡生长性能、抗氧化能力、免疫功能和血清生化指标的影响[J].动物营养学报,2016,28(3):908-915.

[11] LIAO X D,MA G,CAI J,et al.Effects of Clostridium butyricum on growth performance,antioxidation,and immune function of broilers[J].Poultry Science,2015,94(4):662-667.  

[12] 贾志新.丁酸梭菌对樱桃谷肉鸭生长性能、免疫和抗氧化功能及肠道食糜VFA含量的影响[D].硕士学位论文.南京:南京农业大学,2014:23-24.

[13] 张彩云,刘来亭,杜灵广,等.酪酸芽孢杆菌对断奶仔猪生产性能和血清生化指标的影响[J].中国畜牧杂志,2009,45(13):43-45.

[14] 李玉鹏,李海花,王柳懿,等.丁酸梭菌对断奶仔猪生长性能、肠道屏障功能和血清细胞因子含量的影响[J].动物营养学报,2017,29(8):2961-2968.

[15] AMERAH A M,QUILES A,MEDEL P,et al.Effect of pelleting temperature and probiotic supplementation on growth performance and immune function of broilers fed maize/soy-based diets[J].Animal Feed Science and Technology,2013,180(1/2/3/4):55-63.

[16] 曹广添,刘婷婷,周琳,等.丁酸梭菌对致病菌和有益菌的体外作用效果研究[J].中国饲料,2012(4):16-19.

[17] 张玲,周琳,杨彩梅,等.丁酸梭菌与鼠李糖乳杆菌体外混合培养对肠道致病菌的影响[J].中国饲料,2013(21):9-12.

[18] YANG C M,CAO G T,FERKET P R,et al.Effects of probiotic,Clostridium butyricum,on growth performance,immune function,and cecal microflora in broiler chickens[J].Poultry Science,2012,91(9):2121-2129.  

[19] 梁明振,李莉,刘浩.丁酸梭状芽孢杆菌对断奶仔猪肠道微生物区系的影响[J].中国畜牧杂志,2013,49(23):64-67.

[20] ZHANG B K,YANG X,GUO Y M,et al.Effects of dietary lipids and Clostridium butyricum on the performance and the digestive tract of broiler chickens[J].Archives of Animal Nutrition,2011,65(4):329-339.  

[21] 王腾浩,宗鑫,宋德广,等.产抑菌蛋白的丁酸梭菌的筛选和鉴定及体外益生功能研究[J].中国畜牧杂志,2015,51(13):75-81.

[22] 张晓阳,卢忆,马艳莉,等.丁酸梭菌生理功能及应用研究进展[J].中国食物与营养,2012,18(12):31-35.

[23] 刘亭婷,滑静,王晓霞,等.丁酸梭菌对蛋用仔公鸡肠道菌群、形态结构及黏膜免疫相关细胞的影响[J].动物营养学报,2012,24(11):2210-2221.

[24] 刘婷婷,张帅,邓斐月,等.谷氨酰胺与丁酸梭菌对断奶仔猪生长性能、免疫功能、小肠形态和肠道菌群的影响[J].动物营养学报,2011,23(6):998-1005.

[25] RICKLIN D,HAJISHENGALLIS G,YANG K,et al.Complement:a key system for immune surveillance and homeostasis[J].Nature Immunology,2010,11(9):785-797.  

[26] HUA M C,LIN T Y,LAI M W,et al.Probiotic Bio-Three induces Th1 and anti-inflammatory effects in PBMC and dendritic cells[J].World Journal of Gastroenterology,2010,16(28):3529-3540.  

[27] LIU J M,FU Y Y,ZHANG H,et al.The hepatoprotective effect of the probiotic Clostridium butyricum against carbon tetrachloride-induced acute liver damage in mice[J].Food & Function,2017,8(11):4042-4052.  

[28] 王柳懿,李海花,李玉鹏,等.丁酸梭菌对仔猪回肠免疫信号通路相关蛋白和血清细胞因子的影响[J].中国畜牧杂志,2017,53(8):84-88.

[29] ZHAO X,GUO Y M,GUO S S,et al.Effects of Clostridium butyricum and Enterococcus faecium on growth performance,lipid metabolism,and cecal microbiota of broiler chickens[J].Applied Microbiology and Biotechnology,2013,97(14):6477-6488.  

[30] YOSHIDA K,SHIMIZUGAWA T,ONO M,et al.Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase[J].Journal of Lipid Research,2002,43(11):1770-1772.  

[31] 赵旭.丁酸梭菌对肉鸡脂肪代谢的影响及其机理研究[D].博士学位论文.北京:中国农业大学,2014:79-84.

[32] SHANG H X,SUN J,CHEN Y Q.Clostridium butyricum CGMCC0313.1 modulates lipid profile,insulin resistance and colon homeostasis in obese mice[J].PLoS One,2016,11(4):e0154373.

[33] ALIZADEH M R,MAHDAVI A H,RAHMANI H R,et al.Clove bud (Syzygium aromaticum) improved blood and hepatic antioxidant indices in laying hens receiving low n-6 to n-3 ratios[J].Journal of Animal Physiology and Animal Nutrition,2017,101(5):881-892.  

[34] OKEUDO N J,MOSS B W.Interrelationships amongst carcass and meat quality characteristics of sheep[J].Meat Science,2005,69(1):1-8.  

[35] LIAO X D,WU R J,MA G,et al.Effects of Clostridium butyricum on antioxidant properties,meat quality and fatty acid composition of broiler birds[J].Lipids in Health and Disease,2015,14:36.

[36] YANG X,ZHANG B,GUO Y,et al.Effects of dietary lipids and Clostridium butyricum on fat deposition and meat quality of broiler chickens[J].Poultry Science,2010,89(2):254-260.  

[37] KAWASAKI S,NAKAGAWA T,NISHIYAMA Y,et al.Effect of oxygen on the growth of Clostridium butyricum (type species of the genus Clostridium),and the distribution of enzymes for oxygen and for active oxygen species in Clostridia[J].Journal of Fermentation and Bioengineering,1998,86(4):368-372.  

[38] 廖秀冬.丁酸梭菌的筛选及其对动物抗氧化能力和肉鸡肉品质影响的研究[D].博士学位论文.北京:中国农业大学,2015:26-31.

[39] OHSAWA I,ISHIKAWA M,TAKAHASHI K.Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals[J].Nature Medicine,2007,13(6):688-694.  

[40] MARTARELLI D,VERDENELLI M C,SCURI S,et al.Effect of a probiotic intake on oxidant and antioxidant parameters in plasma of athletes during intense exercise training[J].Current Microbiology,2011,62(6):1689-1696.  

[41] CHAUHAN R,VASANTHAKUMARI A S,PANWAR H,et al.Amelioration of colitis in mouse model by exploring antioxidative potentials of an indigenous probiotic strain of Lactobacillus fermentum Lf1[J].Biomed Research International,2014,2014:206732.
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