综述 Review

岩藻糖介导微生物与肠道上皮细胞的互作及其机制

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  • 1. 中国农业科学院北京畜牧兽医研究所, 农业部奶及奶制品质量安全控制重点实验室, 北京 100193;
    2. 中国农业 科学院北京畜牧兽医研究所, 农业部奶产品质量安全风险评估实验室(北京), 北京 100193;
    3. 中国农业科学院北京畜牧兽医研究所, 动物营养学国家重点实验室, 北京 100193;
    4. 华中农业大学动物科学技术学院, 武汉 430070
张晓音(1991-),女,河南商丘人,博士研究生,从事反刍动物营养与产品品质调控的研究。E-mail:951770634@qq.com

收稿日期: 2018-01-05

  网络出版日期: 2018-07-20

基金资助

国家重点研发计划(2017YFD0500502);现代农业产业技术体系(CARS-36);中国农业科学院科技创新工程(ASTIP-IAS12)

Fucose as a Mediator of Intestinal Microbiota and Epithelial Cells and Its Mechanism

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  • 1. Key Laboratory of Quality and Safety Control for Milk and Dairy Products of Ministry of Agriculture, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    2. Laboratory of Quality and Safety Risk Assessment for Dairy Products of Ministry of Agriculture(Beijing), Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    3. State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    4. College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China

Received date: 2018-01-05

  Online published: 2018-07-20

摘要

岩藻糖是肠道上皮细胞黏蛋白糖基化的重要糖基,可以作为肠道微生物的能量物质,参与肠道微生物的黏附、定植以及免疫调节,对于促进肠道微生物稳态,维持肠道健康有重要作用。本文主要对岩藻糖基化过程,岩藻糖在肠道中的积极调控作用以及肠道微生物、免疫细胞对岩藻糖表达的诱导进行综述,以期为维持肠道微生物稳态和肠道健康提供新的参考。

本文引用格式

张晓音, 赵圣国, 骆超超, 郑楠, 王加启 . 岩藻糖介导微生物与肠道上皮细胞的互作及其机制[J]. 动物营养学报, 2018 , 30(7) : 2473 -2479 . DOI: 10.3969/j.issn.1006-267x.2018.07.006

Abstract

Fucose is an important sugar group of fucosylation in intestinal epithelial cells. As an energy source for gut microbiota, fucose is involved in the adhesion, planting and immune regulation of microbiota, which plays an important role in promoting gut microbial homeostasis and keeping intestine health. In this review, we elucidated the process of fucosylation, constructive regulatory roles of fucose in gut microbiota, induction of intestinal microbiota and immune cells on fucosylation, which potentially provided theoretical foundation for improving the homeostasis of intestinal microbiota and health of intestine.

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