动物营养学报 >

2018 , Vol. 30 >Issue 7: 2683 - 2689

DOI: https://doi.org/10.3969/j.issn.1006-267x.2018.07.028

饲料营养 Feed science and technology

丁酸梭菌对断奶仔猪生长性能、肠道结构和免疫功能的影响

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  • 1. 浙江大学动物科学学院, 浙江省饲料与动物营养重点实验室, 农业部(华东)动物营养与饲料重点实验室, 浙江大学动物分子营养学教育部重点实验室, 杭州 310058;
    2. 南京农业大学动物科技学院, 南京 210095;
    3. 湖北绿雪生物产业有限公司, 咸宁 437110
郑有秀(1993-),女,湖北恩施人,硕士研究生,动物营养与饲料科学专业。E-mail:249362708@qq.com

收稿日期: 2017-12-25

  网络出版日期: 2018-07-20

基金资助

浙江省科技厅重点研发计划项目（2015C02022）；浙江省饲料与动物营养重点实验室开放基金（201705）

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Effects of Clostridium butyricum on Growth Performance, Intestinal Structure and Immune Function of Weaned Piglets

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  • 1. Key Laboratory of Feed and Animal Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture, Key Laboratory of Animal Molecular Nutrition, Ministry of Education, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China;
    2. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China;
    3. Hubei Green Snow Biological Industry Co., Ltd., Xianning 437110, China

Received date: 2017-12-25

  Online published: 2018-07-20

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摘要

本试验旨在研究饲粮添加丁酸梭菌对断奶仔猪生长性能、肠道结构和免疫功能的影响。选取（25±1）日龄、体重（6.24±0.32）kg的健康"杜×长×大"杂交仔猪360头，随机分为5个组，每组4个重复，每个重复18头猪。对照组饲喂基础饲粮，试验组分别饲喂在基础饲粮中添加250、500、1 000和2 000 mg/kg丁酸梭菌的试验饲粮。试验期30 d。结果表明：1）250和1 000 mg/kg丁酸梭菌添加组断奶仔猪的平均日采食量（ADFI）显著低于对照组（P<0.05）；250和500 mg/kg丁酸梭菌添加组的腹泻率较对照组分别显著降低了40.99%和44.32%（P<0.05）。2）丁酸梭菌添加组断奶仔猪的空肠绒毛高度较对照组分别显著提高了32.23%、35.71%、33.59%和47.36%（P<0.05），空肠绒毛高度/隐窝深度较对照组分别显著或极显著提高了47.24%（P<0.01）、48.03%（P<0.01）、19.69%（P<0.05）和22.83%（P<0.05）。3）饲粮添加丁酸梭菌显著提高断奶仔猪的血清免疫球蛋白A（IgA）和免疫球蛋白G（IgG）含量（P<0.05），各组的血清免疫球蛋白M（IgM）、补体3（C3）和补体4（C4）含量则无显著差异（P>0.05）。结果提示，25~55日龄断奶仔猪饲粮添加250~500 mg/kg丁酸梭菌可改善断奶仔猪肠道结构，增强机体免疫功能。

关键词： 丁酸梭菌; 断奶仔猪; 生长性能; 肠道结构; 免疫

本文引用格式

郑有秀, 王超, 邹晓庭, 王丽, 卢建军 . 丁酸梭菌对断奶仔猪生长性能、肠道结构和免疫功能的影响[J]. 动物营养学报, 2018 , 30(7) : 2683 -2689 . DOI: 10.3969/j.issn.1006-267x.2018.07.028

Abstract

This study was conducted to investigate the effects of dietary Clostridium butyricum on growth performance, intestinal structure and immune function of weaned piglets. Three hundred and sixty (25±1) days of age healthy "Duroc×Landrace×Yorkshire" hybrid piglets with the body weight of (6.24±0.32) kg were randomly divided into 5 groups with 4 replicates per group and 18 piglets per replicate. Piglets in control group were fed a basal diet, and those in experimental groups were fed the basal diet supplemented with 250, 500, 1 000 and 2 000 mg/kg Clostridium butyricum, respectively. The experiment lasted for 30 days. The results showed as follows:1) the average daily feed intake (ADFI) of weaned piglets in 250 and 1 000 mg/kg Clostridium butyricum supplemented groups was significantly lower than that in control group (P<0.05). Compared with control group, diarrhea rate in 250 and 500 mg/kg Clostridium butyricum supplemented groups was significantly decreased by 40.99% and 44.32% (P<0.05), respectively. 2) Compared with control group, villous height of jejunum of weaned piglets in Clostridium butyricum supplemented groups was significantly increased by 32.23%, 35.71%, 33.59% and 47.36% (P<0.05), respectively; and the ratio of villous height to crypt depth of jejunum was significantly increased by 47.24% (P<0.01), 48.03% (P<0.01), 19.69% (P<0.05) and 22.83% (P<0.05), respectively. 3) Dietary Clostridium butyricum significantly increased the contents of immunoglobulin A (IgA) and immunoglobulin G (IgG) in serum of weaned piglets (P<0.05), and there were no significant differences in the contents of immunoglobulin M (IgM), complement 3 (C3) and complement 4 (C4) in serum among all groups (P>0.05). The results indicate that diet supplemented with 250 to 500 mg/kg Clostridium butyricum can improve intestinal structure and immune function of weaned piglets from 25 to 55 days of age.

Key words： Clostridium butyricum; weaned piglets; growth performance; intestinal structure; immunity

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