综述 Review

益生菌对Toll样受体-核转录因子-κB信号通路调控作用的研究进展

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  • 黑龙江八一农垦大学动物科技学院, 大庆 163319
聂炼(1992-),男,山西大同人,硕士研究生,从事动物营养与饲料科学研究。E-mail:517121271@qq.com

收稿日期: 2018-04-17

  网络出版日期: 2018-11-20

基金资助

国家自然科学基金项目(31472120);黑龙江八一农垦大学研究生创新基金(YJSCX2017-Y21);黑龙江省农垦总局重点研发项目(HNK135-04-03)

Research Progress in Regulation of Toll-Like Receptor-Nuclear Factor-κB Signaling Pathway by Probiotics

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  • College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China

Received date: 2018-04-17

  Online published: 2018-11-20

摘要

Toll样受体(TLR)是宿主细胞识别各种致病微生物的主要模式识别受体,核转录因子-κB(NF-κB)是TLR下游信号通路中的枢纽,TLR-NF-κB信号通路几乎存在于所有细胞中。当细胞受到刺激时会激发TLR-NF-κB信号通路,进而引起炎症、免疫和许多病理反应。益生菌具有提高免疫力、丰富肠道有益菌和抑制肠道疾病炎性因子产生的作用,一些特定的益生菌可以调控TLR-NF-κB信号通路进而调节炎性因子的表达,改善肠道黏膜炎症。本文主要综述了TLR和NF-κB的主要结构功能、TLR-NF-κB信号通路以及益生菌对TLR-NF-κB信号通路的调控作用,为进一步研究益生菌在宿主机体内的作用提供新的思路。

本文引用格式

聂炼, 张爱忠, 姜宁, 杨卓妮娜 . 益生菌对Toll样受体-核转录因子-κB信号通路调控作用的研究进展[J]. 动物营养学报, 2018 , 30(11) : 4342 -4348 . DOI: 10.3969/j.issn.1006-267x.2018.11.009

Abstract

Toll-like receptor (TLR) is the main pattern recognition receptor for host cells to identify various pathogenic microorganisms. Nuclear factor-κB (NF-κB) is the hub of downstream signaling pathway of TLR, and TLR-NF-κB signaling pathway exists in almost all cells. When cells are stimulated, the TLR-NF-κB signaling pathway is stimulated which leads to inflammation, immunity and many pathological reactions. Probiotics can enhance immunity, enrich intestine beneficial bacteria and inhibit the production of inflammatory factors in the intestinal diseases. Some specific probiotics can regulate the TLR-NF-κB signaling pathway to regulate the expression of inflammatory factors and improve the intestinal mucosa inflammation. In this paper, the main structural functions of TLR and NF-κB, TLR-NF-κB signaling pathway, and the regulation mechanisms of probiotics on TLR-NF-κB signaling pathway were reviewed which provided a new idea for further study on the role of probiotics in the host organism.

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