[1] MOAL V L L,SERVIN A.The front line of enteric host defense against unwelcome intrusion of harmful microorganisms:mucins,antimicrobial peptides,and microbiota[J].Clinical Microbiology Reviews,2006,19(2):315-337.
[2] KESIMER M,KIRKHAM S,PICKLES R J,et al.Tracheobronchial air-liquid interface cell culture:a model for innate mucosal defense of the upper airways?[J].American Journal of Physiology:Lung Cellular and Molecular Physiology,2009,296(1):L92-L100.
[3] PRZYBYLA L M,THEUNISSEN T W,JAENISCH R,et al.Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3[J].Stem Cells,2013,31(6):1097-1106.
[4] MARTÍNEZ-AUGUSTIN O,RIVERO-GUTIÉRREZ B,MASCARAQUE C,et al.Food derived bioactive peptides and intestinal barrier function[J].International Journal of Molecular Sciences,2014,15(12):22857-22873.
[5] 胡艳艳,刘小伟.肠道杯状细胞结构和功能的研究进展[J].国际病理科学与临床杂志,2013,33(5):424-430.
[6] MCCAULEY H A,GUASCH G.Three cheers for the goblet cell:maintaining homeostasis in mucosal epithelia[J].Trends in Molecular Medicine,2015,21(8):492-503.
[7] DAVIS C W,DICKEY B F.Regulated airway goblet cell mucin secretion[J].Annual Review of Physiology,2008,70(1):487-512.
[8] MOWAT A M.Anatomical basis of tolerance and immunity to intestinal antigens[J].Nature Reviews Immunology,2003,3(4):331-341.
[9] JOHANSSON M E V,THOMSSON K A,HANSSON G C.Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component,the Muc2 mucin,is strongly bound to the fcgbp protein[J].Journal of Proteome Research,2009,8(7):3549-3557.
[10] JOHANSSON M E V,GUSTAFSSON J K,SJÖBERG K E,et al.Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model[J].PLoS One,2010,5(8):e12238.
[11] PELASEYED T,BERGSTRÖM J H,GUSTAFSSON J K,et al.The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system[J].Immunological Reviews,2014,260(1):8-20.
[12] HATTRUP C L,GENDLER S J.Structure and function of the cell surface (tethered) mucins[J].Annual Review of Physiology,2008,70(1):431-457.
[13] DO S I,KIM K,KIM D H,et al.Associations between the expression of mucins (MUC1,MUC2,MUC5AC,and MUC6) and clinicopathologic parameters of human breast ductal carcinomas[J].Journal of Breast Cancer,2013,16(2):152-158.
[14] 黄春兰,曾悦.杯状细胞及肠道黏液屏障的功能研究[J].国际消化病杂志,2017,37(6):357-360.
[15] MACKIE A R,ROUND A N,RIGBY N M,et al.The role of the mucus barrier in digestion[J].Food Digestion,2012,3(1/2/3):8-15.
[16] CONE R A.Barrier properties of mucus[J].Advanced Drug Delivery Reviews,2009,61(2):75-85.
[17] ATUMA C,STRUGALA V,ALLEN A,et al.The adherent gastrointestinal mucus gel layer:thickness and physical state
in vivo[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2001,280(5):G922-G929.
[18] FLOREY H W.The secretion and function of intestinal mucus[J].Gastroenterology,1962,43:326-329.
[19] GRUBER P,RUBINSTEIN A,LI V H K,et al.Gastric emptying of nondigestible solids in the fasted dog[J].Journal of Pharmaceutical Sciences,1987,76(2):117-122.
[20] CONE R A.Chapter 4-mucus[M]//MESTECKY J,BIENENSTOCK J,LAMM M E,et al.Mucosal Immunology.3rd ed.Amsterdam:Elsevier Academic Press,2005:49-72.
[21] LAI S K,O'HANLON E,HARROLD S,et al.Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus[J].Proceedings of the National Academy of Sciences of the United States of America,2007,104(5):1482-1487.
[22] FORSTNER G.Signal transduction packaging and secretion of mucins[J].Annual Review of Physiology,1995,57(1):585-605.
[23] 李俊媛.结肠癌患者与结肠癌大鼠肠道菌群的比较分析[D].硕士学位论文.大连:大连医科大学,2017.
[24] 王婷婷.肠道菌群结构变化与结直肠癌发生发展关系的研究[D].博士学位论文.上海:上海交通大学,2012.
[25] ANDRIANIFAHANANA M,MONIAUX N,BATRA S K.Regulation of mucin expression:mechanistic aspects and implications for cancer and inflammatory diseases[J].Biochimica et Biophysica Acta:Reviews on Cancer,2006,1765(2):189-222.
[26] JOHANSSON M E V,HANSSON G C.Immunological aspects of intestinal mucus and mucins[J].Nature Reviews Immunology,2016,16(10):639-649.
[27] VENTURA M,TURRONI F,STRATI F,et al.The gut microbiota in health and disease[M]//MARCHESI J R.Human Microbiota and Microbiome.Wallingford:CABI,2014.
[28] VARUM F J O,VEIGA F,SOUSA J S,et al.An investigation into the role of mucus thickness on mucoadhesion in the gastrointestinal tract of pig[J].European Journal of Pharmaceutical Sciences,2010,40(4):335-341.
[29] CEBRA J J.Influences of microbiota on intestinal immune system development[J].The American Journal of Clinical Nutrition,1999,69(5):1046S-1051S.
[30] SINGH M,VOHRA H,KUMAR L,et al.Induction of systemic and mucosal immune response in mice immunised with porins of
Salmonella typhi[J].Journal of Medical Microbiology,1999,48(1):79-88.
[31] JOHANSSON M E V,GUSTAFSSON J K,HOLMÉN-LARSSON J,et al.Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis[J].Gut,2014,63(2):281-291.
[32] JAKOBSSON H E,RODRÍGUEZ-PIÑEIRO A M,SCHÜTTE A,et al.The composition of the gut microbiota shapes the colon mucus barrier[J].Embo Reports,2015,16(2):164-177.
[33] CARIO E,GERKEN G,PODOLSKY D K.Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function[J].Gastroenterology,2007,132(4):1359-1374.
[34] RAKOFF-NAHOUM S,PAGLINO J,ESLAMI-VARZANEH F,et al.Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis[J].Cell,2004,118(2):229-241.
[35] HAMER H M,JONKERS D,VENEMA K,et al.Review article:the role of butyrate on colonic function[J].Alimentary Pharmacology & Therapeutics,2008,27(2):104-119.
[36] HANSSON G C.Role of mucus layers in gut infection and inflammation[J].Current Opinion in Microbiology,2012,15(1):57-62.
[37] STECHER B,HAPFELMEIER S,MÜLLER C,et al.Flagella and chemotaxis are required for efficient induction of
Salmonella enterica serovar Typhimurium colitis in streptomycin-pretreated mice[J].Infection and Immunity,2004,72(7):4138-4150.
[38] BERGSTROM K S B,KISSOON-SINGH V,GIBSON D L,et al.Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa[J].PLoS Pathogens,2010,6(5):e1000902.
[39] PHILLIPSON M,JOHANSSON M E V,HENRIKSNÄS J,et al.The gastric mucus layers:constituents and regulation of accumulation[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2008,295(4):G806-G812.
[40] HEAZLEWOOD C K,COOK M C,ERI R,et al.Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis[J].PLoS Medicine,2008,5(3):e54.
[41] BIRCHENOUGH G M H,NYSTRÖM E E L,JOHANSSON M E V,et al.A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion[J].Science,2016,352(6293):1535-1542.
[42] PETERSSON J,SCHREIBER O,HANSSON G C,et al.Importance and regulation of the colonic mucus barrier in a mouse model of colitis[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2011,300(2):G327-G333.
[43] DEPLANCKE B,GASKINS H R.Microbial modulation of innate defense:goblet cells and the intestinal mucus layer[J].The American Journal of Clinical Nutrition,2001,73(6):1131S-1141S.
[44] BECKER S,OELSCHLAEGER T A,WULLAERT A,et al.Bacteria Regulate intestinal epithelial cell differentiation factors both
in vitro and
in vivo[J].PLoS One,2013,8(2):e55620.
[45] XAVIER R J,PODOLSKY D K.Unravelling the pathogenesis of inflammatory bowel disease[J].Nature,2007,448(7152):427-434.
[46] 李冰,于岩波.肠黏液屏障在肠道中的作用[J].世界华人消化杂志,2017,25(19):1764-1771.
[47] 董文逍,曹海龙,王邦茂.杯状细胞在肠道疾病发病中作用的研究进展[J].国际消化病杂志,2015,35(4):244-246,269.
[48] STREMMEL W.Mucosal protection by phosphatidylcholine as new therapeutic concept in ulcerative colitis[J].Zeitschrift Für Gastroenterologie,2013,51(4):384-389.
[49] DIEBEL L N,LIBERATI D M.Reinforcement of the intestinal mucus layer protects against
Clostridium difficile intestinal injury
in vitro[J].Journal of the American College of Surgeons,2014,219(3):460-468.
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