李成良, 齐广海, 彭鹏, 方热军 . 芳香烃受体调控肠道炎症的研究进展[J]. 动物营养学报, 2018 , 30(12) : 4776 -4785 . DOI: 10.3969/j.issn.1006-267x.2018.12.002

[1] POLAND A P,GLOVER E,KENDE A S.Stereospecific,high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol:evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase[J].Journal of Biological Chemistry,1976,25(16):4936-4946.



[2] POLAND A P,GLOVER E.Genetic expression of aryl hydrocarbon hydroxylase by 2,3,7,8 tetrachlorodibenzo-p-dioxin:evidence for a receptor mutation in genetically non-responsive mice[J].Molecular Pharmacology,1975,11(4):389-398.



[3] STOCKINGER B,DI MEGLIO P,GIALITAKIS M,et al.The aryl hydrocarbon receptor:multitasking in the immune system[J].Annual Review of Immunology,2014,32(1):403-432.  



[4] HAHN M E.Aryl hydrocarbon receptors:diversity and evolution[J].Chemico-Biological Interactions,2002,141(1/2):131-160.



[5] WALLER C L,MCKINNEY J D.Three-dimensional quantitative structure-activity relationships of dioxins and dioxin-like compounds:model validation and ah receptor characterization[J].Chemical Research in Toxicology,1995,8(6):847-858.  



[6] ANTONSSON C,WHITELAW M L,MCGUIRE J,et al.Distinct roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the basic helix-loop-helix and PAS domains[J].Molecular and Cellular Biology,1995,15(2):756-765.  



[7] ELFERINK C J,GE N L,LEVINE A.Maximal aryl hydrocarbon receptor activity depends on an interaction with the retinoblastoma protein[J].Molecular Pharmacology,2001,59(4):664-673.  



[8] 蔺远,张爱茜,王连生.芳烃受体与配体结合特定结构域的结构预测与分析[C]//第四届全国环境化学学术大会论文汇编.南京:中国化学会,2008.



[9] 段毅涛,赵辉,黄鹤.芳香烃受体内外源性配体研究进展[J].环境与健康杂志,2013,30(5):456-459.



[10] KIMURA A,NAKA T,NOHARA K,et al.Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells[J].Proceedings of the National Academy of Sciences of the United States of America,2008,105(28):9721-9726.  



[11] WANG H K,YEH C H,IWAMOTO T,et al.Dietary flavonoid naringenin induces regulatory T cells via an aryl hydrocarbon receptor mediated pathway[J].Journal of Agricultural and Food Chemistry,2012,60(9):2171-2178.  



[12] DINATALE B C,MURRAY I A,SCHROEDER J C,et al.kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling[J].Toxicological Sciences,2010,115(1):89-97.  



[13] HENRY E C,WELLE S L,GASIEWICZ T A.TCDD and a putative endogenous AhR ligand,ITE,elicit the same immediate changes in gene expression in mouse lung fibroblasts[J].Toxicological Sciences,2010,114(1):90-100.  



[14] LEHMANN G M,XI X,KULKARNI A A,et al.The aryl hydrocarbon receptor ligand ITE inhibits TGFβ1-induced human myofibroblast differentiation[J].American Journal of Pathology,2011,178(4):1556-1557.  



[15] WALL R J,HE G C,DENISON M S,et al.Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context[J].Toxicology,2012,297(1/2/3):26-33.



[16] GAD S C.Toxicology of the gastrointestinal tract[M].New York:CRC Press,2007:10.



[17] ESSER C,RANNUG A,STOCKINGER B.The aryl hydrocarbon receptor in immunity[J].Trends in Immunology,2009,30(9):447-454.  



[18] PASTORKOVÁ B,VRZALOVÁ A,BACHLEDA P,et al.Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes[J].Food and Chemical Toxicology,2017,103:122-132.



[19] SCHMIDT J V,BRADFIELD C A.Ah receptor signaling pathways[J].Annual Review of Cell and Developmental Biology,1996,12(1):55-89.  



[20] QIU J,GUO X H,CHEN Z M E,et al.Group 3 Innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora[J].Immunity,2013,39(2):386-399.  



[21] ARSENESCU R,ARSENESCU V,ZHONG J,et al.Role of the xenobiotic receptor in inflammatory bowel disease[J].Inflammatory Bowel Diseases,2011,17(5):1149-1162.  



[22] MONTELEONE I,RIZZO A,SARRA M,et al.Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract[J].Gastroenterology,2011,141(1):237-248.e1.  



[23] XUE J,NGUYEN D T,HABTEZION A.Aryl hydrocarbon receptor regulates pancreatic IL-22 production and protects mice from acute pancreatitis[J].Gastroenterology,2012,143(6):1670-1680.  



[24] SINGH N P,SINGH U P,SINGH B,et al.Activation of aryl hydrocarbon receptor (AhR) leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis[J].PLoS One,2011,6(8):e23522.



[25] TAKAMURA T,HARAMA D,MATSUOKA S,et al.Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice[J].Immunology & Cell Biology,2010,88(6):685-689.  



[26] TAKAMURA T,HARAMA D,FUKUMOTO S,et al.Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis[J].Immunology & Cell Biology,2011,89(7):817-822.  



[27] 李良子,刘中泽,陈维刚,等.芳香烃受体对小鼠结肠炎的缓解作用及机制研究[J].免疫学杂志,2017,33(1):13-17.



[28] SHIZUMA T,MORI H,FUKUYAMA N.Protective effect of tryptophan against dextran sulfate sodium-induced experimental colitis[J].Turkish Journal of Gastroenterology,2013,24(1):30-35.



[29] ISLAM J,SATO S,WATANABE K,et al.Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice[J].The Journal of Nutritional Biochemistry,2017,42:43-50.



[30] LI Y,INNOCENTIN S,WITHERS D R,et al.Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation[J].Cell,2011,147(3):629-640.  



[31] GIRARDI M,GLUSAC E,FILLER R B,et al.The distinct contributions of murine T cell receptor (TCR) γδ⁺ and TCRαβ⁺ T cells to different stages of chemically induced skin cancer[J].The Journal of Experimental Medicine,2003,198(5):747-755.  



[32] PUDDINGTON L,OLSON S,LEFRANÇOIS L.Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis[J].Immunity,1994,1(9):733-739.  



[33] FAHRER A M,KONIGSHOFER Y,KERR E M,et al.Attributes of γδ intraepithelial lymphocytes as suggested by their transcriptional profile[J].Proceedings of the National Academy of Sciences of the United States of America,2001,98(18):10261-10266.  



[34] WILSON C L,OUELLETTE A J,SATCHELL D P,et al.Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense[J].Science,1999,286(5437):113-117.  



[35] ABREU M T.Toll-like receptor signalling in the intestinal epithelium:how bacterial recognition shapes intestinal function[J].Nature Reviews Immunology,2010,10(2):131-144.  



[36] SPITS H,ARTIS D,COLONNA M,et al.Innate lymphoid cells-a proposal for uniform nomenclature[J].Nature Reviews Immunology,2013,13(2):145-149.  



[37] HWANG Y Y,MCKENZIE A N.Innate lymphoid cells in immunity and disease[C]//KATSIKIS P,SCHOENBERGER S,PULENDRAN B.Crossroads Between Innate and Adaptive Immunity.New York:Springer,2013,785:9-26.



[38] SPITS H,DI SANTO J P.The expanding family of innate lymphoid cells:regulators and effectors of immunity and tissue remodeling[J].Nature Immunology,2011,12(1):21-27.  



[39] LEE J,CELLA M,MCDONALD K G,et al.AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch[J].Nature Immunology,2011,13(2):144-151.



[40] KISS E A,VONARBOURG C,KOPFMANN S,et al.Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles[J].Science,2011,334(6062):1561-1565.  



[41] SUN Y V,BOVERHOF D R,BURGOON L D,et al.Comparative analysis of dioxin response elements in human,mouse and rat genomic sequences[J].Nucleic Acids Research,2004,32(15):4512-4523.  



[42] JUX B,KADOW S,LUECKE S,et al.The aryl hydrocarbon receptor mediates UVB radiation-induced skin tanning[J].Journal of Investigative Dermatology,2011,131(1):203-210.  



[43] KADOW S,JUX B,ZAHNER S P,et al.Aryl hydrocarbon receptor is critical for homeostasis of invariant γδT cells in the murine epidermis[J].Journal of Immunology,2011,187(6):3104-3110.  



[44] CHAPPAZ S,GÄRTNER C,RODEWALD H R,et al.Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development[J].The Journal of Immunology,2010,185(6):3514-3519.  



[45] STEVENS E A,MEZRICH J D,BRADFIELD C A.The aryl hydrocarbon receptor:a perspective on potential roles in the immune system[J].Immunology,2009,127(3):299-311.  



[46] LÜGERING A,ROSS M,SIEKER M,et al.CCR6 identifies lymphoid tissue inducer cells within cryptopatches[J].Clinical & Experimental Immunology,2010,160(3):440-449.  



[47] POSSOT C,SCHMUTZ S,CHEA S,et al.Notch signaling is necessary for adult,but not fetal,development of RORγt+ innate lymphoid cells[J].Nature Immunology,2011,12(10):949-958.  



[48] TRIFARI S,KAPLAN C D,TRAN E H,et al.Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from Th-17,Th1 and Th2 cells[J].Nature Immunology,2009,10(8):864-871.  



[49] ALAM M S,MAEKAWA Y,KITAMURA A,et al.Notch signaling drives IL-22 secretion in CD4⁺ T cells by stimulating the aryl hydrocarbon receptor[J].Proceedings of the National Academy of Sciences of the United States of America,2010,107(13):5943-5948.  



[50] ZENEWICZ L A,FLAVELL R A.IL-22 and inflammation:leukin' through a glass onion[J].European Journal of Immunology,2008,38(12):3265-3268.  



[51] ZHENG Y,VALDEZ P A,DANILENKO D M,et al.Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens[J].Nature Medicine,2008,14(3):282-289.  



[52] ZELANTE T,IANNITTI R G,CUNHA C,et al.Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22[J].Immunity,2013,39(2):372-385.  



[53] SCHIERING C,WINCENT E,METIDJI A,et al.Feedback control of AHR signalling regulates intestinal immunity[J].Nature,2017,542(7640):242-245.  



[54] BI Y J,LIU G W,YANG R F.Reciprocal modulation between Th17 and other helper T cell lineages[J].Journal of Cellular Physiology,2011,226(1):8-13.  



[55] COOMBES J L,ROBINSON N J,MALOY K J,et al.Regulatory T cells and intestinal homeostasis[J].Immunological Reviews,2005,204(1):184-194.  



[56] READ S,MALMSTRÖM V,POWRIE F.Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of Cd25⁺Cd4⁺ regulatory cells that control intestinal inflammation[J].Journal of Experimental Medicine,2000,192(2):295-302.  



[57] MOTTET C,UHLIG H H,POWRIE F.Cutting edge:cure of colitis by CD4⁺CD25⁺ regulatory T cells[J].The Journal of Immunology,2003,170(8):3939-3943.  



[58] VELDHOEN M,HOCKING R J,ATKINS C J,et al.TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells[J].Immunity,2006,24(2):179-189.  



[59] KIMURA A,KISHIMOTO T.Th17 cells in inflammation[J].International Immunopharmacology,2011,11(3):319-322.  



[60] ZHANG L Y,ZHANG Y J,ZHONG W W,et al.Heme Oxygenase-1 ameliorates dextran sulfate sodium-induced acute murine colitis by regulating Th17/Treg cell balance[J].Journal of Biological Chemistry,2014,289(39):26847-26858.  



[61] MEZRICH J D,FECHNER J H,ZHANG X J,et al.An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells[J].The Journal of Immunology,2010,185(6):3190-3198.  



[62] CHEN Z J,LIN F,GAO Y Y,et al.FOXP3 and RORγt:transcriptional regulation of Treg and Th17[J].International Immunopharmacology,2011,11(5):536-542.  



[63] PUNJ S,KOPPARAPU P,JANG H S,et al.Benzimidazoisoquinolines:a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-Dependent Tregs and prevent murine graft-versus-host disease[J].PLoS One,2014,9(2):e88726.



[64] CHRISTIAANSEN A F,BOGGIATTO P M,VARGA S M.Limitations of Foxp3⁺ Treg depletion following viral infection in DEREG mice[J].Journal of Immunological Methods,2014,406:58-65.



[65] MIZUNO T,SUZUKI R,UMEKI S,et al.Crossreactivity of antibodies to canine CD25 and Foxp3 and identification of canine CD4⁺CD25⁺Foxp3⁺ cells in canine peripheral blood[J].Journal of Veterinary Medical Science,2009,71(12):1561-1568.  



[66] CHAUDHRY A,RUDRA D,TREUTING P,et al.CD4⁺ regulatory t cells control TH17 responses in a Stat3-dependent manner[J].Science,2009,326(5955):986-991.  



[67] QUINTANA F J,WEINER H L.Environmental control of Th17 differentiation[J].European Journal of Immunology,2009,39(3):655-657.  



[68] YANG E J,LEE J,LEE S Y,et al.EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1α with Th17/Treg control[J].PLoS One,2014,9(2):e86062.



[69] ROSILLO M A,SÁNCHEZ-HIDALGO M,SÁNCHEZ-FIDALGO S,et al.Dietary extra-virgin olive oil prevents inflammatory response and cartilage matrix degradation in murine collagen-induced arthritis[J].European Journal of Nutrition,2016,55(1):315-325.