综述 Review

维生素A增强动物抗病毒能力的作用及其机制研究进展

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  • 1. 四川农业大学动物营养研究所, 成都 611130;
    2. 教育部动物抗病营养重点实验室, 成都 611130;
    3. 四川农业大学动物科技学院, 成都 611130
冉智明(1993-),男,重庆人,硕士研究生,从事动物抗病营养研究。E-mail:bizikaran@outlook.com

收稿日期: 2018-05-12

  网络出版日期: 2018-12-19

基金资助

国家自然科学基金项目(31601952);四川省教育厅项目(14ZB0021)

Research Progress on Enhancing Effect of Vitamin A on Antiviral Ability of Animals and Its Mechanism

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  • 1. Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China;
    2. Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, Chengdu 611130, China;
    3. College of Animal Science, Sichuan Agricultural University, Chengdu 611130, China

Received date: 2018-05-12

  Online published: 2018-12-19

摘要

维生素A有增强动物抗病毒能力的作用,其代谢产物全反式视黄酸是增强抗病毒能力的主要活性形式。维生素A能通过提高视黄酸诱导基因Ⅰ受体介导的干扰素-Ⅰ表达以增强天然抗病毒能力,提高B淋巴细胞的免疫球蛋白A产生以增强适应性抗病毒能力,以及调节肠道菌群增加具有抗病毒活性乳杆菌的数量等途径发挥抗病毒作用。本文就维生素A增强动物抗病毒能力的作用及其机制作一简要综述。

本文引用格式

冉智明, 陈代文, 余冰, 赵叶 . 维生素A增强动物抗病毒能力的作用及其机制研究进展[J]. 动物营养学报, 2018 , 30(12) : 4842 -4848 . DOI: 10.3969/j.issn.1006-267x.2018.12.011

Abstract

Vitamin A has the function of enhancing antiviral ability of animals, and the all-trans retinoic acid is the main active form to enhance antiviral ability. It acts to potentiate innate antiviral immune responses by increasing the retinoic acid-induced gene Ⅰ receptor-dependent expression of interferon-Ⅰ, and to enhance adaptive antiviral immune responses by increasing immunoglobulin A production of B lymphocytes, and to modulates gut microbiome increases the Lactobacillus populations of anti-viral activity and other ways to exert an antiviral effect. In this paper, the enhancing effect of vitamin A on antiviral ability of animals and its mechanism are briefly reviewed.

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