为了探讨发酵白酒糟在育肥猪饲粮中添加的可行性，本试验比较研究了不同比例的发酵茅台酒糟（FML）替代基础饲粮对育肥猪血浆生化参数和抗氧化指标的影响。试验选用平均体重为（39.95±2.15） kg的杜×长×大三元杂交去势公猪48头，根据体重随机分为4组，每组12个重复，每个重复1头猪，饲喂于自动饲喂系统中。对照组饲喂基础饲粮，试验组用FML分别替代5%、10%和15%的基础饲粮。于试猪平均体重达60、75和110 kg时，每组随机选取8头，前腔静脉采血，离心分离血浆，测定生化参数和抗氧化指标。结果显示：体重为60 kg时，与对照组相比，5%替代组血浆低密度脂蛋白-胆固醇（LDL-C）含量和α-淀粉酶（α-AMY）活性显著升高（P<0.05），血浆丙氨酸氨基转移酶（ALT）活性显著降低（P<0.05）；10%替代组血浆α-AMY活性显著升高（P<0.05），血浆葡萄糖（GLU）含量和ALT活性显著降低（P<0.05）；15%替代组血浆甘油三酯含量、谷胱甘肽过氧化物酶（GSH-Px）活性和谷胱甘肽（GSH）含量显著升高（P<0.05），血浆丙二醛（MDA）含量显著降低（P<0.05）。体重为75 kg时，与对照组相比，5%替代组血浆LDL-C含量和过氧化氢酶（CAT）活性显著升高（P<0.05），血浆高密度脂蛋白-胆固醇（HDL-C）含量显著降低（P<0.05）；10%替代组血浆LDL-C含量及CAT和GSH-Px活性显著升高（P<0.05），血浆天门冬氨酸氨基转移酶（AST）和乳酸脱氢酶（LDH）活性显著降低（P<0.05）；15%替代组血浆CAT、超氧化物歧化酶（SOD）和GSH-Px活性显著升高（P<0.05），血浆尿素氮（UN）、HDL-C、GLU含量以及α-AMY、AST和LDH活性显著降低（P<0.05）。体重为110 kg时，与对照组相比，5%替代组血浆ALT活性显著降低（P<0.05），血浆α-AMY活性显著升高（P<0.05），血浆UN含量显著降低（P<0.05）；10%和15%替代组血浆总蛋白含量显著增加（P<0.05），血浆UN含量和ALT活性显著降低（P<0.05）；15%替代组血浆AST活性显著降低（P<0.05）。综上所述，FML替代部分基础饲粮可改变育肥猪的机体代谢和抗氧化能力，其作用效果与替代量有关；其中，15%的替代量可显著改善75和110 kg育肥猪的机体氮代谢能力，增强60 kg育肥猪的机体抗氧化能力。

This study was conducted to explore the possibility of dietary supplementation with fermented distiller's grains. We analyzed the effects of dietary substitution in a basal diet with different ratios of fermented Mao-tai lees (FML) on plasma biochemical parameters and antioxidant indices of finishing pigs. A total of 48 healthy Duroc×Large White×Landrace barrows with average body weight (BW) of (39.95±2.15) kg were used and randomly allocated to one of four groups with 12 replicates per group and 1 pig in each replicate, which were fed in an automatic feeding system. The pigs in the control group were fed a basal diet, and those in experiment groups were fed a diet with 5%, 10% or 15% FML to replace the equal ratio of basal diet, respectively. Eight pigs per group were randomly selected when they gained 60, 75 and 110 kg of average BW, and blood samples were collected by precaval vein. The plasma was obtained by centrifuging for analyzing biochemical parameters and antioxidant indices. The results showed that, in pigs with 60 kg BW, compared with the control group, the plasma low density lipoprotein-cholesterol (LDH-C) content and α-amylase (α-AMY) activity were significantly increased (P<0.05), while the plasma alanine aminotransferase (ALT) activity was significantly decreased (P<0.05) in 5% substituted group; the plasma α-AMY activity was significantly increased (P<0.05), while the plasma glucose (GLU) content and ALT activity were significantly decreased (P<0.05) in 10% substituted group; the plasma triglyceride content, glutathione peroxidase (GSH-Px) activity and glutathione (GSH) content were significantly increased (P<0.05), while the plasma malonaldehyde (MDA) content was significantly decreased (P<0.05) in 15% substituted group. In pigs with 75 kg BW, compared with the control group, the plasma LDL-C content and catalase (CAT) activity were significantly increased (P<0.05), while the plasma high density lipoprotein-cholesterol (HDL-C) content was significantly decreased (P<0.05) in 5% substituted group; the plasma LDL-C content and activities of CAT and GSH-Px were significantly increased (P<0.05), while the plasma activities of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were significantly decreased (P<0.05) in 10% substituted group; the plasma activities of CAT, superoxide dismutase (SOD) and GSH-Px were significantly increased (P<0.05), while the plasma contents of urea nitrogen (UN), HDL-C and GLU as well as activities of α-AMY, AST and LDH were significantly decreased (P<0.05) in 15% substituted group. In pigs with 110 kg BW, compared with the control group, the plasma ALT activity was significantly decreased (P<0.05), the plasma α-AMY activity was significantly increased (P<0.05), while the plasma UN content was significantly decreased (P<0.05) in 5% substituted group; the plasma total protein content were significantly increased (P<0.05), while the plasma UN content and ALT activity were significantly decreased (P<0.05) in 10% and 15% substituted groups. In addition, the plasma AST activity in 15% substituted group was significantly decreased (P<0.05). Collectively, these findings suggest that dietary FML supplementation to replace parts of basal diet can alter the metabolism and antioxidant capacity of finishing pigs, depending on the replacement ratio in diet; dietary supplementation with 15% FML to replace the equal ratio of basal diet improves the nitrogen metabolism of pigs with 75 and 110 kg BW and enhances the antioxidant capacity of pigs with 60 kg BW.