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壳寡糖对动物机体免疫和炎症调节作用及其机制的研究进展

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  • 北京农学院动物科学技术学院, 奶牛营养学北京市重点实验室, 北京 102206
张华(1986-),男,山东泰安人,讲师,博士,从事临床兽医学研究。E-mail:huazhang0914@163.com

收稿日期: 2018-06-14

  网络出版日期: 2019-01-16

基金资助

国家自然科学基金项目(31702302);北京市教委科技计划项目(SQKM201710020011);北京农学院青年教师科研基金;大北农青年教师科研基金;北京农学院奶牛营养学北京市重点实验室开放课题

Research Progress on Regulatory Effect and Mechanism of Chitooligosaccharides on Immunity and Inflammation in Animals

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  • Beijing Key Laboratory for Dairy Cow Nutrition, Beijing University of Agriculture, Beijing 102206, China

Received date: 2018-06-14

  Online published: 2019-01-16

摘要

壳寡糖(COS)是一种由β-1,4糖苷键连接的D-氨基葡萄糖低聚物,可由节肢动物和昆虫的外骨骼以及真菌细胞壁中的甲壳素经脱乙酰和水解作用生成。COS代表了一类天然聚合物,具有水溶性和低黏度等理化特性,有良好的药理学作用和多种有益的生物学活性,如抗炎、抗氧化、免疫刺激、抗微生物、抗肿瘤、促进组织再生、增强药物和DNA传递以及钙的吸收等。COS在机体内的作用机制涉及多条重要的信号通路,通路的主要作用因子以及激酶包括核因子-κB(NF-κB)、丝裂原活化蛋白激酶(MAPK)和腺苷酸活化蛋白激酶(AMPK)等。本文主要总结了COS对动物机体免疫和炎症调节作用及其机制的最新进展,并讨论了未来的研究方向。

本文引用格式

张华, 童津津, 张肇南, 蒋林树 . 壳寡糖对动物机体免疫和炎症调节作用及其机制的研究进展[J]. 动物营养学报, 2019 , 31(1) : 15 -23 . DOI: 10.3969/j.issn.1006-267x.2019.01.002

Abstract

Chitosan oligosaccharides (COS) is a D-glucosamine oligomer linked by β-1,4 glucosidic linkages that can be deacetylated and hydrolyzed by exoskeletons of arthropods and insects and chitin in fungal cell walls. COS represents a class of natural polymers that not only have physicochemical properties such as water solubility and low viscosity, but also have good pharmacological effects and safety as well as a variety of beneficial biological activities such as anti-inflammatory, anti-oxidant, immune stimulating, anti-microorganisms, anti-tumor, promote tissue regeneration, enhance drug and DNA transmission and enhance calcium absorption. The mechanism of COS involved in a number of important signaling pathways, including the inhibition of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) and activation of AMP-activated protein kinase (AMPK). This article summarizes the recent progress of COS on the regulation of immune and inflammation in animal body and its mechanism, and discusses the future research directions.

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