[1] HANKE D,POHLMANN A,SAUTER-LOUIS C,et al.Porcine epidemic diarrhea in europe:in-detail analyses of disease dynamics and molecular epidemiology[J].Viruses,2017,9(7):177.
[2] DUBREUIL J D,ISAACSON R E,SCHIFFERLI D M.Animal enterotoxigenic
Escherichia coli[J].Ecosal Plus,2016,7(1):1-17.
[3] QADRI F,SVENNERHOLM A M,FARUQUE A S G,et al.Enterotoxigenic
Escherichia coli in developing countries:epidemiology,microbiology,clinical features,treatment,and prevention[J].Clinical Microbiology Reviews,2005,18(3):465-483.
[4] ZHANG H H,XU Y P,ZHANG Z J,et al.Protective immunity of a multivalent vaccine candidate against piglet diarrhea caused by enterotoxigenic
Escherichia coli (ETEC) in a pig model[J].Vaccine,2018,36(5):723-728.
[5] SPELLBERG B,BARTLETT J G,GILBERT D N.The future of antibiotics and resistance[J].The New England Journal of Medicine,2013,368(4):299-302.
[6] ZHANG W P,SACK D A.Current progress in developing subunit vaccines against enterotoxigenic
Escherichia coli-associated diarrhea[J].Clinical and Vaccine Immunology,2015,22(9):983-991.
[7] FLECKENSTEIN J M,RASKO D A.Overcoming enterotoxigenic
Escherichia coli pathogen diversity:translational molecular approaches to inform vaccine design[M]//THOMAS S.Vaccine Design.New York:Humana Press,2016:363-383.
[8] CODDENS A,VALIS E,BENKTANDER J,et al.Erythrocyte and porcine intestinal glycosphingolipids recognized by F4 fimbriae of enterotoxigenic
Escherichia coli[J].PLoS One,2011,6(9):e23309.
[9] REN J,YAN X M,AI H S,et al.Susceptibility towards enterotoxigenic
Escherichia coli F4ac diarrhea is governed by the
MUC13 gene in pigs[J].PLoS One,2012,7(9):e44573.
[10] DUBREUIL J D.
Escherichia coli STb enterotoxin:a multifaceted molecule[M]//GOPALAKRISHNAKONE P,STILES B,ALAPE-GIRÍN A,et al.Microbial Toxins.Dordrecht:Springer Press,2016:1-18.
[11] STIRM S,ØRSKOV I,ØRSKOV F.K88,an episome-determined protein antigen of
Escherichia coli[J].Nature,1966,209(5022):507-508.
[12] 刘绍琼.mTOR信号通路在LPS诱导肉鸡肠道黏膜免疫应激中的作用[D].博士学位论文.泰安:山东农业大学,2015.
[13] GUO S H,AL-SADI R,SAID H M,et al.Lipopolysaccharide causes an increase in intestinal tight junction permeability
in vitro and
in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14[J].The American Journal of Pathology,2013,182(2):375-387.
[14] GUO S H,AL-SADI R,NIGHOT P K,et al.75 Lipopolysaccharide induced increase in intestinal tight junction permeability is regulated by FAK dependent activation of MYD88 signaling pathway[J].Gastroenterology,2014,146(5):S-21.
[15] GUO S H,NIGHOT M,AL-SADI R,et al.Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR4 signal transduction pathway activation of FAK and MyD88[J].The Journal of Immunology,2015,195(10):4999-5010.
[16] STEWART R K,DANGI A,HUANG C,et al.A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion-and endotoxin-induced acute liver injury[J].Journal of Hepatology,2014,60(2):298-305.
[17] CARCHMAN E H,WHELAN S,LOUGHRAN P,et al.Experimental sepsis-induced mitochondrial biogenesis is dependent on autophagy,TLR4,and TLR9 signaling in liver[J].The FASEB Journal,2013,27(12):4703-4711.
[18] CAO S T,ZHANG Q H,WANG C C,et al.LPS challenge increased intestinal permeability,disrupted mitochondrial function and triggered mitophagy of piglets[J].Innate Immunity,2018,24(4):221-230.
[19] ZHU H L,PI D A,LENG W,et al.Asparagine preserves intestinal barrier function from LPS-induced injury and regulates CRF/CRFR signaling pathway[J].Innate Immunity,2017,23(6):546-556.
[20] PARK C M,PARK J Y,NOH K H,et al.
Taraxacum officinale Weber extracts inhibit LPS-induced oxidative stress and nitric oxide production via the NF-κB modulation in RAW 264.7 cells[J].Journal of Ethnopharmacology,2011,133(2):834-842.
[21] ALONSO C,VICARIO M,PIGRAU M,et al.Intestinal barrier function and the brain-gut axis[M]//LYTE M,CRYAN J F.Microbial Endocrinology:the Microbiota-Gut-Brain Axis in Health And Disease.New York:Springer Press,2014:73-113.
[22] BRZOZOWSKI B,MAZUR-BIALY A,PAJDO R,et al.Mechanisms by which stress affects the experimental and clinical inflammatory bowel disease (IBD):role of brain-gut axis[J].Current Neuropharmacology,2016,14(8):892-900.
[23] BAUMGART D C,DIGNASS A U.Intestinal barrier function[J].Current Opinion in Clinical Nutrition and Metabolic Care,2002,5(6):685-694.
[24] CHOY A,ROY C R.Autophagy and bacterial infection:an evolving arms race[J].Trends in Microbiology,2013,21(9):451-456.
[25] CASTREJÍN-JIMÉNEZ N S,LEYVA-PAREDES K,HERNÁNDEZ-GONZÁLEZ J C,et al.The role of autophagy in bacterial infections[J].Bioscience Trends,2015,9(3):149-159.
[26] CEMMA M,BRUMELL J H.Interactions of pathogenic bacteria with autophagy systems[J].Current Biology,2012,22(13):R540-R545.
[27] ILAN Y.Leaky gut and the liver:a role for bacterial translocation in nonalcoholic steatohepatitis[J].World Journal of Gastroenterology,2012,18(21):2609-2618.
[28] LIU X X,LI H R,LU A,et al.Reduction of intestinal mucosal immune function in heat-stressed rats and bacterial translocation[J].International Journal of Hyperthermia,2012,28(8):756-765.
[29] CRAPSER J,RITZEL R,VERMA R,et al.Ischemic stroke induces gut permeability and enhances bacterial translocation leading to sepsis in aged mice[J].Aging,2016,8(5):1049-1060.
[30] AKBARI P,BRABER S,Varasteh S,et al.The intestinal barrier as an emerging target in the toxicological assessment of mycotoxins[J].Archives of Toxicology,2017,91(3):1007-1029.
[31] BISCHOFF S C,BARBARA G,BUURMAN W,et al.Intestinal permeability-a new target for disease prevention and therapy[J].BMC Gastroenterology,2014,14:189.
[32] NAKASHIMA R,KAMATA Y,NISHIKAWA Y.Effects of
Escherichia coli heat-stable enterotoxin and guanylin on the barrier integrity of intestinal epithelial T84 cells[J].Veterinary Immunology and Immunopathology,2013,152(1/2):78-81.
[33] DEVRIENDT B,STUYVEN E,VERDONCK F,et al.Enterotoxigenic
Escherichia coli (K88) induce proinflammatory responses in porcine intestinal epithelial cells[J].Developmental & Comparative Immunology,2010,34(11):1175-1182.
[34] CAMPBELL H K,MAIERS J L,DEMALI K A.Interplay between tight junctions & adherens junctions[J].Experimental Cell Research,2017,358(1):39-44.
[35] RALEIGH D R,BOE D M,YU D,et al.Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function[J].Journal of Cell Biology,2011,193(3):565-582.
[36] MUKIZA C N,DUBREUIL J D.
Escherichia coli heat-stable toxin b impairs intestinal epithelial barrier function by altering tight junction proteins[J].Infection and Immunity,2013,81(8):2819-2827.
[37] NASSOUR H,DUBREUIL J D.
Escherichia coli STb enterotoxin dislodges claudin-1 from epithelial tight junctions[J].PLoS One,2014,9(11):e113273.
[38] STAFF PO.Correction:escherichia coli STb enterotoxin dislodges claudin-1 from epithelial tight junctions[J].PLoS One,2015,10(3):e0118983.
[39] WU X,SU D.Enterotoxigenic
Escherichia coli infection induces tight junction proteins expression in mice[J].Iranian Journal of Veterinary Research,2018,19(1):35-40.
[40] HILL D R,HUANG S,NAGY M S,et al.Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium[J].eLife,2017,6:e29132.
[41] XU C L,WANG Y M,SUN R,et al.Modulatory effects of vasoactive intestinal peptide on intestinal mucosal immunity and microbial community of weaned piglets challenged by an enterotoxigenic
Escherichia coli (K88)[J].PLoS One,2014,9(8):e104183.
[42] MESSORI S,TREVISI P,SIMONGIOVANNI A,et al.Effect of susceptibility to enterotoxigenic
Escherichia coli F4 and of dietary tryptophan on gut microbiota diversity observed in healthy young pigs[J].Veterinary Microbiology,2013,162(1):173-179.
[43] POP M,PAULSON J N,CHAKRABORTY S,et al.Individual-specific changes in the human gut microbiota after challenge with enterotoxigenic
Escherichia coli and subsequent ciprofloxacin treatment[J].BMC Genomics,2016,17:440.
[44] SETTY P,FOUTZ T,BOEDEKER E C.A new mouse model for human enterotoxigenic
E. coli (ETEC) infection:effect of the gut microbiota on intestinal secretion[J].Gastroenterology,2017,152(5):S815-S816.
[45] DAUDELIN J F,LESSARD M,BEAUDOIN F,et al.Administration of probiotics influences F4(K88)-positive enterotoxigenic
Escherichia coli attachment and intestinal cytokine expression in weaned pigs[J].Veterinary Research,2011,42:69.
[46] REN W K,YIN J,XIAO H,et al.Intestinal microbiota-derived GABA mediates interleukin-17 expression during enterotoxigenic
Escherichia coli infection[J].Frontiers in Immunology,2016,7(9):685-700.
[47] WANG X G,HARDWIDGE P R.Enterotoxigenic
Escherichia coli prevents host NF-κB activation by targeting IκBα polyubiquitination[J].Infection and Immunity,2012,80(12):4417-4425.
[48] WANG G C,GEISBRECHT B V,RUETER C,et at.Enterotoxigenic
Escherichia coli flagellin inhibits TNF-induced NF-κB activation in intestinal Epithelial cells[J].Pathogens,2017,6(2):18.
[49] BAO W B,YE L,PAN Z Y,et al.Analysis of polymorphism in the porcine TLR4 gene and its expression related to
Escherichia coli F18 infection[J].Czech Journal of Animal Science,2011,56(11):475-482.
[50] LOOS M,GEENS M,SCHAUVLIEGE S,et al.Role of heat-stable enterotoxins in the induction of early immune responses in piglets after infection with enterotoxigenic
Escherichia coli[J].PLoS One,2012,7(7):e41041.
[51] REN W K,YIN J,DUAN J L,et al.Mouse intestinal innate immune responses altered by enterotoxigenic
Escherichia coli (ETEC) infection[J].Microbes and Infection,2014,16(11):954-961.
[52] SUGIHARTO S,POULSEN A S R,CANIBE N,et al.Effect of bovine colostrum feeding in comparison with milk replacer and natural feeding on the immune responses and colonisation of enterotoxigenic
Escherichia coli in the intestinal tissue of piglets[J].British Journal of Nutrition,2015,113(6):923-934.
[53] KIM S J,KWON C H,PARK B C,et al.Effects of a lipid-encapsulated zinc oxide dietarysupplement,on growth parameters and intestinal morphology in weanling pigs artificially infected with enterotoxigenic
Escherichia coli[J].Journal of Animal Science and Technology,2015,57:4.
[54] LV Y,LI X N,ZHANG L,et al.Injury and mechanism of recombinant
E. coli expressing STa on piglets colon[J].Journal of Veterinary Medical Science,2018,80(2):205-212.
[55] GHOSAL A,CHATTERJEE N S,CHOU T,et al.Enterotoxigenic
Escherichia coli infection and intestinal thiamin uptake:studies with intestinal epithelial Caco-2 monolayers[J].American Journal of Physiology-Cell Physiology,2013,305(11):C1185-C1191.
[56] ASHOKKUMAR B,KUMAR J S,HECHT G A,et al.Enteropathogenic
Escherichia coli inhibits intestinal vitamin B
1 (thiamin) uptake:studies with human-derived intestinal epithelial Caco-2 cells[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2009,297(4):G825-G833.
[57] ZACHOS N C,KOVBASNJUK O,FOULKE-ABEL J,et al.Human enteroids/colonoids and intestinal organoids functionally recapitulate normal intestinal physiology and pathophysiology[J].Journal of Biological Chemistry,2015,291(8):3759-3766.
[58] SATO T,VRIES R G,SNIPPERT H J,et al.Single Lgr5 stem cells build crypt-villus structures
in vitro without a mesenchymal niche[J].Nature,2009,459(7244):262-265.
[59] ANDERSSON-ROLF A,ZILBAUER M,KOO B K,et al.Stem cells in repair of gastrointestinal epithelia[J].Physiology,2017,32(4):278-289.
[60] PATTISON A M,BLOMAIN E S,MERLINO D J,et al.Intestinal enteroids model guanylate cyclase c-dependent secretion induced by heat-stable enterotoxins[J].Infection and Immunity,2016,84(10):3083-3091.
[61] LEOCÁDIO P C L,ANTUNES M M,TEIXEIRA L G,et al.
L-Arginine pretreatment reduces intestinal mucositis as induced by 5-FU in mice[J].Nutrition and Cancer,2015,67(3):486-493.
[62] REN W K,DUAN J L,YIN J,et al.Dietary
L-glutamine supplementation modulates microbial community and activates innate immunity in the mouse intestine[J].Amino Acids,2014,46(10):2403-2413.
[63] LIU G,REN W K,FANG J,et al.
L-glutamine and
L-arginine protect against enterotoxigenic
Escherichia coli infection via intestinal innate immunity in mice[J].Amino Acids,2017,49(12):1945-1954.
[64] TANG Y L,TAN B,XIONG X,et al.Methionine deficiency reduces autophagy and accelerates death in intestinal epithelial cells infected with enterotoxigenic
Escherichia coli[J].Amino Acids,2015,47(10):2199-2204.
[65] LI H H,ZHANG L,CHEN L B,et al.
Lactobacillus acidophilus alleviates the inflammatory response to enterotoxigenic
Escherichia coli K88 via inhibition of the NF-κB and p38 mitogen-activated protein kinase signaling pathways in piglets[J].BMC Microbiology,2016,16:273.
[66] XIAO D F,WANG Y F,LIU G,et al.Effects of chitosan on intestinal inflammation in weaned pigs challenged by enterotoxigenic
Escherichia coli[J].PLoS One,2014,9(8):e104192.
[67] ZHANG W,ZHU Y H,YANG J C,et al.A selected
Lactobacillus rhamnosus strain promotes egfr-independent akt activation in an enterotoxigenic
Escherichia coli K88-infected IPEC-J2 cell model[J].PLoS One,2015,10(4);10:e0125717.
[68] 谷巍,王丽荣,孙明杰,等.嗜酸乳杆菌发酵中药对产肠毒素大肠杆菌K88所致腹泻的防治作用[J].中国畜牧兽医,2018,45(3):798-806.
[69] 李亚雄,仇正兴,何闪,等.日粮中添加微生态制剂对断奶仔猪生长性能、肠道健康和由F18+大肠杆菌引起的仔猪腹泻的影响[J].国外畜牧学(猪与禽),2016(4):61-66.
[70] 蒲俊宁,陈代文,田刚,等.苯甲酸、凝结芽孢杆菌和牛至油复合添加剂对大肠杆菌攻毒仔猪生长性能、抗氧化能力和空肠消化吸收功能的影响[J].动物营养学报,2018,30(9):3652-3661.
[71] SKROVANEK S,DIGUILIO K,BAILEY R,et al.Zinc and gastrointestinal disease[J].World Journal of Gastrointestinal Pathophysiology,2014,5(4):496-513.
[72] HEIM G,SWEENEY T,O'SHEA C J,et al.Effect of maternal supplementation with seaweed extracts on growth performance and aspects of gastrointestinal health of newly weaned piglets after challenge with enterotoxigenic
Escherichia coli K88[J].British Journal of Nutrition,2014,112(12):1955-1965.
京公网安备 11010802041926号