胡瑶莲, 张恒志, 陈代文, 何军, 郑萍, 毛湘冰, 虞洁, 黄志清, 罗钧秋, 罗玉衡, 余冰 . 白藜芦醇对生长育肥猪抗氧化能力、空肠黏膜免疫及结肠菌群的影响[J]. 动物营养学报, 2019 , 31(1) : 459 -468 . DOI: 10.3969/j.issn.1006-267x.2019.01.054

[1] 郭爱伟,熊春梅,周杰珑,等.植物提取物对家禽肠道健康的调控及其作用机制[J].动物营养学报,2017,29(8):2613-2621.

[2] 陈代文,余冰,张克英.饲料安全及保障措施[C]//饲料营养研究进展——中国畜牧兽医学会动物营养学分会第四届全国饲料营养学术研讨会论文集.南京:《畜牧与兽医》杂志社,2002.

[3] JANG M S,CAI L N,UDEANI G O,et al.Cancer chemopreventive activity of resveratrol,a natural product derived from grapes[J].Science,1997,275(5297):218-220.  

[4] 韩晶晶,刘炜,毕玉平.白藜芦醇的研究进展[J].生物工程学报,2008,24(11):1851-1859.

[5] AZORÍN-ORTUÑO M,YAÑÉZ-GASCÍN M J,PALLARÉS F J,et al.Pharmacokinetic study of trans-resveratrol in adult pigs[J].Journal of Agricultural and Food Chemistry,2010,58(20):11165-11171.  

[6] VITRAC X,DESMOULIÈRE A,BROUILLAUD B,et al.Distribution of[¹⁴C]-trans-resveratrol,a cancer chemopreventive polyphenol,in mouse tissues after oral administration[J].Life Sciences,2003,72(20):2219-2233.  

[7] WALLE T,HSIEH F,DELEGGE M H,et al.High absorption but very low bioavailability of oral resveratrol in humans[J].Drug Metabolism and Disposition,2004,32(12):1377-1382.  

[8] 方伟.高脂膳食和氧化蛋白对小鼠肠道菌群和氧化还原状态的影响[D].硕士学位论文.无锡:江南大学,2012.

[9] DE LA LASTRA C A,VILLEGAS I.Resveratrol as an antioxidant and pro-oxidant agent:mechanisms and clinical implications[J].Biochemical Society Transactions,2007,35(5):1156-1160.  

[10] 杨兰泽,王宜娟,李三强,等.白藜芦醇的抗衰老作用[J].中国老年学杂志,2013,33(3):628-629.

[11] 庞卫军,孙世铎,白亮,等.白藜芦醇对猪原代前体脂肪细胞的增殖与分化及Sirt1基因转录表达时序的影响[J].生物工程学报,2006,22(5):850-855.

[12] CROMWELL G L.Antimicrobial and promicrobial agents[M]//LEWIS A J,SOUTHERN L L.Swine nutrition.USA:CRC Press,2001.

[13] 李巍伟.白藜芦醇抑菌作用及其机制研究[D].硕士学位论文.石家庄:河北医科大学,2008.

[14] LIU L L,HE J H,XIE H B,et al.Resveratrol induces antioxidant and heat shock protein mRNA expression in response to heat stress in black-boned chickens[J].Poultry Science,2013,93(1):54-62.

[15] AHMED S T,HOSSAIN M E,KIM G M,et al.Effects of resveratrol and essential oils on growth performance,immunity,digestibility and fecal microbial shedding in challenged piglets[J].Asian-Australasian Journal of Animal Sciences,2013,26(5):683-690.  

[16] 王俊文.饲粮添加白藜芦醇对接种蓝耳病弱毒苗育肥猪生产性能和免疫功能及肉品质的影响[D].硕士学位论文.雅安:四川农业大学,2012.

[17] ZHANG C,LUO J Q,YU B,et al.Effects of resveratrol on lipid metabolism in muscle and adipose tissues:a reevaluation in a pig model[J].Journal of Functional Foods,2015,14:590-595.

[18] DJORDJEVIC V B.Free radicals in cell biology[J].International Review of Cytology,2004,237:57-91.

[19] 赵云罡,徐建兴.线粒体,活性氧和细胞凋亡[J].生物化学与生物物理进展,2001,28(2):168-171.

[20] 张成,耿照玉,赵晓惠.白藜芦醇的生物学功能及其在畜禽生产中的应用[J].动物营养学报,2017,29(11):3837-3843.

[21] CAO Z X,LI Y B.Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes:protection against oxidative and electrophilic injury[J].European Journal of Pharmacology,2004,489(1/2):39-48.

[22] RUBIOLO J A,MITHIEUX G,VEGA F V.Resveratrol protects primary rat hepatocytes against oxidative stress damage:activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes[J].European Journal of Pharmacology,2008,591(1/2/3):66-72.

[23] ZHANG C,LUO J Q,YU B,et al.Dietary resveratrol supplementation improves meat quality of finishing pigs through changing muscle fiber characteristics and antioxidative status[J].Meat Science,2015,102:15-21.

[24] 杨琤琤.老瓜头生物总碱体外抗氧化抗炎作用研究[D].硕士学位论文.银川:宁夏医科大学,2014.

[25] GE L,LI C,WANG Z,et al.Suppression of oxidative stress and apoptosis in electrically stimulated neonatal rat cardiomyocytes by resveratrol and underlying mechanisms[J].Journal of Cardiovascular Pharmacology,2017,70(6):396-404.

[26] SURH Y J,CHUN K S,CHA H H,et al.Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals:down-regulation of COX-2 and iNOS through suppression of NF-κB activation[J].Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis,2001,480-481:243-268.

[27] ASHIKAWA K,MAJUMDAR S,BANERJEE S,et al.Piceatannol inhibits TNF-induced NF-κB activation and NF-κB-mediated gene expression through suppression of IκBα kinase and p65 phosphorylation[J].The Journal of Immunology,2002,169(11):6490-6497.  

[28] 李佳曦,汪受传,徐建亚,等.白藜芦醇对RSV感染BALB/c小鼠肺泡灌洗液TNF-α,IL-1β,IL-6表达的调控趋势[J].中国中药杂志,2012,37(10):1451-1454.

[29] LI T,FAN G X,WANG W,et al.Resveratrol induces apoptosis,influences IL-6 and exerts immunomodulatory effect on mouse lymphocytic leukemia both in vitro and in vivo[J].International Immunopharmacology,2007,7(9):1221-1231.  

[30] SINGH U P,SINGH N P,SINGH B,et al.Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-κB activation to abrogate dextran sulfate sodium-induced colitis[J].Journal of Pharmacology and Experimental Therapeutics,2010,332(3):829-839.  

[31] 高润颖,蔡美琴.白藜芦醇对肠道保护作用的研究进展[J].上海交通大学学报:医学版,2016,36(2):302-306.

[32] PUUPPONEN-PIMIÄ R,AURA A M,OKSMAN-CALDENTEY K M,et al.Development of functional ingredients for gut health[J].Trends in Food Science & Technology,2002,13(1):3-11.  

[33] 罗丽媛.葡萄细胞系白藜芦醇的合成动态及其代谢调控研究[D].硕士学位论文.兰州:甘肃农业大学,2010.

[34] 路东亮.姜烯酚类似物和白藜芦醇代谢产物的抗氧化和癌预防活性研究[D].博士学位论文.兰州:兰州大学,2013.

[35] QIAO Y,SUN J,XIA S F,et al.Effects of resveratrol on gut microbiota and fat storage in a mouse model with high-fat-induced obesity[J].Food & Function,2014,5(6):1241-1249.  

[36] ETXEBERRIA U,ARIAS N,BOQUÉ N,et al.Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats[J].The Journal of Nutritional Biochemistry,2015,26(6):651-660.  

[37] ESPÍN J C,GONZÁLEZ-SARRÍAS A,TOMÁS-BARBERÁN F A.The gut microbiota:a key factor in the therapeutic effects of (poly) phenols[J].Biochemical Pharmacology,2017,139:82-93.

[38] LARROSA M,YAÑÉZ-GASCÍN M J,SELMA M V,et al.Effect of a low dose of dietary resveratrol on colon microbiota,inflammation and tissue damage in a DSS-induced colitis rat model[J].Journal of Agricultural and Food Chemistry,2009,57(6):2211-2220.  

[39] 李永军,李巍伟,王鑫,等.白藜芦醇对葡萄球菌抗菌活性研究[J].中国实验诊断学,2008,12(1):58-60.

[40] ZHANG C,ZHAO X H,YANG L,et al.Resveratrol alleviates heat stress-induced impairment of intestinal morphology,microflora,and barrier integrity in broilers[J].Poultry Science,2017,96(12):4325-4332.  

[41] DOLARA P,LUCERI C,DE FILIPPO C,et al.Red wine polyphenols influence carcinogenesis,intestinal microflora,oxidative damage and gene expression profiles of colonic mucosa in F344 rats[J].Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis,2005,591(1/2):237-246.

[42] 王挺,李弋.双歧杆菌对D-半乳糖致衰老小鼠的抗衰老作用[J].中国老年学,2007,27(1):47-48.