[1] HANKE D,POHLMANN A,SAUTER-LOUIS C,et al.Porcine epidemic diarrhea in europe:in-detail analyses of disease dynamics and molecular epidemiology[J].Viruses,2017,9(7):177.
[2] TULEMISOVA Z,BIYASHEV K,BIYASHEV B,et al.Prophilaxy of gasstro-intestinal diseases of young animals[J].Journal of Animal and Veterinary Advances,2013,12(22):1645-1650.
[3] BROSNAN J T,BROSNAN M E.Glutamate:a truly functional amino acid[J].Amino Acids,2013,45(3):413-418.
[4] FAN M Z,MATTHEWS J C,ETIENNE N M,et al.Expression of apical membrane
L-glutamate transporters in neonatal porcine epithelial cells along the small intestinal crypt-villus axis[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2004,287(2):G385-G398.
[5] LIN M,ZHANG B L,YU C N,et al.
L-glutamate supplementation improves small intestinal architecture and enhances the expressions of jejunal mucosa amino acid receptors and transporters in weaning piglets[J].PLoS One,2014,9(11):e111950.
[6] YIN J,LIU M F,REN W K,et al.Effects of dietary supplementation with glutamate and aspartate on diquat-induced oxidative stress in piglets[J].PLoS One,2015,10(4):e0122893.
[7] JIAO N,WU Z L,JI Y,et al.
L-glutamate enhances barrier and antioxidative functions in intestinal porcine epithelial cells[J].The Journal of Nutrition,2015,145(10):2258-2264.
[8] DENG H S,GERENCSER A A,JASPER H.Signal integration by Ca
2+ regulates intestinal stem-cell activity[J].Nature,2015,528(7581):212-217.
[9] TURNER J R.Intestinal mucosal barrier function in health and disease[J].Nature Reviews Immunology,2009,9(11):799-809.
[10] WU X,ZHANG Y,LIU Z,et al.Effects of oral supplementation with glutamate or combination of glutamate and N-carbamylglutamate on intestinal mucosa morphology and epithelium cell proliferation in weanling piglets[J].Journal of Animal Science,2012,90(Suppl.4):337-339.
[11] TORⅡ K.Physiological roles of dietary glutamate signaling via gut-brain axis for energy expenditure[J].Journal of Gastroenterology.2013,48(4):442-451.
[12] 姜廷波.葡萄糖和赖氨酸水平对仔猪小肠上皮细胞赖氨酸吸收、转运的影响[D].硕士学位论文.长春:吉林农业大学,2017.
[13] 张军.谷氨酸钠在仔猪胃肠道的转运和代谢及机制研究[D].博士学位论文.北京:中国科学院大学,2013.
[14] 周济宏,李幼生,黎介寿.谷氨酰胺转运载体的种类与分布及功能特点[J].医学研究生学报,2007(04):408-411.
[15] HU Q X,OTTESTAD-HANSEN S,HOLMSETH S,et al.Expression of glutamate transporters in mouse liver,kidney,and intestine[J].Journal of Histochemistry & Cytochemistry,2018,66(3):189-202.
[16] FAN M Z,MATTHEWS J C,ETIENNE N M P,et al.Expression of apical membrane
L-glutamate transporters in neonatal porcine epithelial cells along the small intestinal crypt-villus axis[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2004,287(2):G385-G398.
[17] CHEN M X,LI X G,YAN H C,et al.Effect of egg weight on composition,embryonic growth,and expression of amino acid transporter genes in yolk sac membranes and small intestines of the domestic pigeon (
Columba livia)[J].Poultry Science,2016,95(6):1425-1432.
[18] CHEN M X,LI X G,YANG J X,et al.Growth of embryo and gene expression of nutrient transporters in the small intestine of the domestic pigeon (
Columba livia)[J].Journal of Zhejiang University (SCIENCE B),2015,16(6):511-523.
[19] LI X G,CHEN X L,WANG X Q.Changes in relative organ weights and intestinal transporter gene expression in embryos from white olymouth rock and wens yellow feather chickens[J].Comparative Biochemistry and Physiology Part A:Molecular & Integrative Physiology,2013,164(2):368-375.
[20] LI X G,SUI W G,YAN H C,et al.The
in ovo administration of
L-
trans pyrrolidine-2,4-dicarboxylic acid regulates small intestinal growth in chicks[J].Animal,2014,8(10):1677-1683.
[21] ZHANG J,YIN Y L,SHU X G,et al.Oral administration of MSG increases expression of glutamate receptors and transporters in the gastrointestinal tract of young piglets[J].Amino Acids,2013,45(5):1169-1177.
[22] BERGEN W G,WU G Y.Intestinal nitrogen recycling and utilization in health and disease[J].The Journal of Nutrition,2009,139(5):821-825.
[23] WU G Y,BAZER F W,DAVIS T A,et al.Arginine metabolism and nutrition in growth,health and disease[J].Amino Acids,2009,37(1):153-168.
[24] KANAI Y,HEDIGER M A.The glutamate and neutral amino acid transporter family:physiological and pharmacological implications[J].European Journal of Pharmacology,2003,479(1/2/3):237-247.
[25] BLACHIER F,MARIOTTI F,HUNEAU J F,et al.Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences[J].Amino Acids,2007,33(4):547-562.
[26] CREMIN J D,Jr.,FITCH M D,FLEMING S E.Glucose alleviates ammonia-induced inhibition of short-chain fatty acid metabolism in rat colonic epithelial cells[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2003,285(1):G105-G114.
[27] BURRIN D G,STOLL B.Metabolic fate and function of dietary glutamate in the gut[J].The American Journal of Clinical Nutrition,2009,90(3):850S-860S.
[28] REEDS P J,BURRIN D G,STOLL B,et al.Enteral glutamate is the preferential source for mucosal glutathione synthesis in fed piglets[J].American Journal of Physiology,1997,273(2):E408-E415.
[29] BURRIN D G,STOLL B,FERNSTROM J D,et al.Metabolic fate and function of dietary glutamate in the gut[J].American Journal of Clinical Nutrition,2009,90(3):850S-856S.
[30] SURYAWAN A,ORELLANA R A,NGUYEN H V,et al.Activation by insulin and amino acids of signaling components leading to translation initiation in skeletal muscle of neonatal pigs is developmentally regulated[J].American Journal of Physiology:Endocrinology and Metabolism,2007,293(6):E1597-E1605.
[31] WOLFSON R L,CHANTRANUPONG L,SAXTON R A,et al.Sestrin 2 is a leucine sensor for the mTORC1 pathway[J].Science,2016,351(6268):43-48.
[32] HAN J M,JEONG S J,PARK M C,et al.Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway[J].Cell,2012,149(2):410-424.
[33] CHANTRANUPONG L,SCARIA S M,SAXTON R A,et al.The castor proteins are arginine sensors for the mtorc1 pathway[J].Cell,2016,165(1):153-164.
[34] WANG S Y,TSUN Z Y,WOLFSON R L,et al.Metabolism.Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1[J].Science,2015,347(6218):188-194.
[35] LI X G,SUI W G,GAO C Q,et al.
L-glutamate deficiency can trigger proliferation inhibition via down regulation of the mTOR/S6K1 pathway in pig intestinal epithelial cells[J].Journal of Animal Science,2016,94(4):1541-1549.
[36] YE J L,GAO C Q,LI X G,et al.EAAT3 promotes amino acid transport and proliferation of porcine intestinal epithelial cells[J].Oncotarget,2016,7(25):38681-38692.
[37] CLEVERS H.Stem cells:a unifying theory for the crypt[J].Nature,2013,495(7439):53-54.
[38] YAN K S,CHIA L A,LI X N,et al.The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations[J].Proceedings of the National Academy of Sciences of the United States of America,2012,109(2):466-471.
[39] UMAR S.Intestinal stem cells[J].Current Gastroenterology Reports,2010,12(5):340-348.
[40] METCALFE C,KLJAVIN N M,YBARRA R,et al.Lgr5
+ stem cells are indispensable for radiation-induced intestinal regeneration[J].Cell Stem Cell,2014,14(2):149-159.
[41] O'BRIEN L E,SOLIMAN S S,LI X H,et al.Altered modes of stem cell division drive adaptive intestinal growth[J].Cell,2011,147(3):603-614.
[42] DAILEY M J.Nutrient-induced intestinal adaption and its effect in obesity[J].Physiology & Behavior,2014,136:74-78.
[43] KRETZSCHMAR K,CLEVERS H.Wnt/β-catenin signaling in adult mammalian epithelial stem cells[J].Developmental Biology,2017,428(2):273-282.
[44] ZOU W Y,BLUTT S E,ZENG X L,et al.Epithelial WNT ligands are essential drivers of intestinal stem cell activation[J].Cell Reports,2018,22(4):1003-1015.
[45] YIN X L,FARIN H F,ES J H V,et al.Niche-independent high-purity cultures of Lgr5
+ intestinal stem cells and their progeny[J].Nature Methods,2014,11(1):106-112.
[46] XIONG X,YANG H S,TAN B,et al.Differential expression of proteins involved in energy production along the crypt-villus axis in early-weaning pig small intestine[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2015,309(4):G229-G237.
[47] SAMPSON L L,DAVIS A K,GROGG M W,et al.mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice[J].The FASEB Journal,2015,30(3):1263-1275.
[48] MILLER B G,NEWBY T J,STOKES C R,et al.The importance of dietary antigen in the cause of postweaning diarrhea in pigs[J].American Journal of Veterinary Research,1984,45(9):1730-1733.
[49] HAMPSON D J.Alterations in piglet small intestinal structure at weaning[J].Research in Veterinary Science,1986,40(1):32-40.
[50] VAN BEERS-SCHREURS H M G,NABUURS M J A,VELLENGA L,et al.Weaning and the weanling diet influence the villous height and crypt depth in the small intestine of pigs and alter the concentrations of short-chain fatty acids in the large intestine and blood[J].The Journal of Nutrition,1998,128(6):947-953.
[51] TONG M B,LAARVELD A G,VAN KESSEL D L,et al.Effect of segregated early weaning on postweaning small intestinal development in pigs[J].Journal of Animal Science,1999,77(12):3191-3200.
[52] CAMILLERI M,MADSEN K,SPILLER R,et al.Intestinal barrier function in health and gastrointestinal disease[J].Neurogastroenterology & Motility,2012,24(6):503-512.
[53] XIAO W D,FENG Y J,HOLST J J,et al.Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition[J].The FASEB Journal,2014,28(5):2073-2087.
[54] VERMEULEN M A,DE JONG J,VAESSEN M J,et al.Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity[J].World Journal of Gastroenterology,2011,17(12):1569-1573.
[55] MERGA Y,CAMPBELL B J,RHODES J M.Mucosal barrier,bacteria and inflammatory bowel disease:possibilities for therapy[J].Digestive Diseases,2014,32(4):475-483.
[56] DU J,LI X H,LI Y J.Glutamate in peripheral organs:biology and pharmacology[J].European Journal of Pharmacology,2016,784:42-48.
[57] BEZENÇON C,LE COUTRE J,DAMAK S.Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells[J].Chemical Senses,2007,32(1):41-49.
[58] NAKAMURA E,HASUMURA M,SAN GABRIEL A,et al.New frontiers in gut nutrient sensor research:luminal glutamate-sensing cells in rat gastric mucosa[J].Journal of Pharmacological Sciences,2010,112(1):13-18.
[59] TORⅡ K,UNEYAMA H,NAKAMURA E.Physiological roles of dietary glutamate signaling via gut-brain axis due to efficient digestion and absorption[J].Journal of Gastroenterology,2013,48(4):442-451.
[60] KITAMURA A,TSURUGIZAWA T,UEMATSU A,et al.New therapeutic strategy for amino acid medicine:effects of dietary glutamate on gut and brain function[J].Journal of Pharmacological Sciences,2012,118(2):138-144.
[61] JOHANSSON M E V,PHILLIPSON M,PETERSSON J,et al.The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria[J].Proceedings of the National Academy of Sciences of the United States of America,2008,105(39):15064-15069.
[62] AMAGASE K,KIMURA Y,WADA A,et al.Prophylactic effect of monosodium glutamate on NSAID-induced enteropathy in rats[J].Current Pharmaceutical Design,2014,20(16):2783-2790.
[63] AKIBA Y,WATANABE C,MIZUMORI M,et al.Luminal
L-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2009,297(4):G781-G791.
[64] AKIBA Y,KAUNITZ J D.Duodenal chemosensing and mucosal defenses[J].Digestion,2011,83(Suppl.1):25-31.
[65] UNEYAMA H,NⅡJIMA A,SAN GABRIEL A,et al.Luminal amino acid sensing in the rat gastric mucosa[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2006,291(6):G1163-G1170.
[66] AKIBA Y,KAUNITZ J D.Luminal chemosensing and upper gastrointestinal mucosal defenses[J].The American Journal of Clinical Nutrition,2009,90(3):826S-831S.
[67] 左增妍,张彩.肠道黏膜免疫耐受机制研究进展[J].现代免疫学,2015,35(1):68-71.
[68] REZZANI R,CORSETTI G,RODELLA L,et al.Cyclosporine-A treatment inhibits the expression of metabotropic glutamate receptors in rat thymus[J].Acta Histochemica,2003,105(1):81-87.
[69] STURGILL J L,MATHEWS J,SCHERLE P,et al.Glutamate signaling through the kainate receptor enhances human immunoglobulin production[J].Journal of Neuroimmunology,2011,233(1/2):80-89.
[70] PACHECO R,OLIVA H,MARTINEZ-NAVÍO J M,et al.Glutamate released by dendritic cells as a novel modulator of T cell activation[J].The Journal of Immunology,2006,177(10):6695-6704.
[71] RUTH M R,FIELD C J.The immune modifying effects of amino acids on gut-associated lymphoid tissue[J].Journal of Animal Science and Biotechnology,2013,4(1):27.
[72] 段杰林.酸性氨基酸缓解过氧化氢介导仔猪肠道氧化损伤机制研究[D].硕士学位论文.北京:中国科学院大学,2016.
[73] 刘明锋.谷氨酸对断奶仔猪抗氧化能力的影响研究[D].硕士学位论文.长沙:湖南农业大学,2014.
[74] JIANG J,WU X Y,ZHOU X Q,et al.Glutamate ameliorates copper-induced oxidative injury by regulating antioxidant defences in fish intestine[J].British Journal of Nutrition,2016,116(1):70-79.
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