综述 Review

腺苷酸激活蛋白激酶信号通路及其在动物应激过程中的调节功能

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  • 西南大学生物饲料与分子营养实验室, 重庆 400715
陈进超(1993-),男,云南昆明人,硕士研究生,从事单胃动物营养研究。E-mail:805252629@qq.com

收稿日期: 2018-07-16

  网络出版日期: 2019-02-18

基金资助

国家自然科学基金项目(31872370,31772610);国家重点基础研究发展计划(2013CB127300);重庆市留学人才创新计划重点项目(cx2017024)

Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway and Its Regulatory Functions in Process of Animal Stress

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  • Laboratory for Bio-Feed and Animal Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, China

Received date: 2018-07-16

  Online published: 2019-02-18

摘要

腺苷酸激活蛋白激酶(AMPK)是一种在真核细胞生物中广泛存在的丝氨酸/苏氨酸蛋白激酶,作为细胞内最重要的能量感受器,AMPK在细胞生长、繁殖、维持机体能量平衡以及细胞代谢过程中发挥重要的调节作用。AMPK活化主要受细胞内一磷酸腺苷/三磷酸腺苷(AMP/ATP)水平及肝激酶B1、钙调素依赖蛋白激酶活性等因素的影响;在动物处于营养缺乏、热应激、氧化应激等环境中,AMPK通路能做出适应性调整,以降低应激环境对动物的负面影响。本文对AMPK的结构、活性调节以及对处于应激环境中的动物能量代谢的调节进行综述,为缓解畜禽各种应激综合征提供理论参考。

本文引用格式

陈进超, 孙佳静, 张相鑫, 唐志如 . 腺苷酸激活蛋白激酶信号通路及其在动物应激过程中的调节功能[J]. 动物营养学报, 2019 , 31(2) : 575 -583 . DOI: 10.3969/j.issn.1006-267x.2019.02.012

Abstract

Adenosine monophosphate-activated protein kinase (AMPK), which widely exists in eukaryotic cells, is a serine/threonine protein kinase. As the most important energy sensor in cells, AMPK plays an important regulatory role in cell growth, reproduction, maintaining energy balance, and cell metabolism. Its activation is mainly affected by intracellular adenosine monophosphate (AMP)/adenosine triphosphate (ATP), liver kinase B1 and calmodulin-dependent kinase kinase β. In addition, current studies show that AMPK signaling pathway can be adapted to reduce the negative effects of stress on animals under conditions of nutrient deprivation, heat shock, and oxidative stress. In this review, we discuss the structure of AMPK, its activation mechanisms, as well as its regulatory roles and mechanisms in nutrient metabolism under conditions of various stress, with the aim of providing a theoretical reference for alleviating animal stress syndrome.

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