本试验旨在研究谷氨酰胺（Gln）和低聚异麦芽糖（IMO）及其互作效应对断奶仔猪血清免疫指标及抗氧化能力的影响。试验采用2因素3水平析因设计，选取81头28日龄断奶、体重[（7.54±0.62）kg]相近的健康"杜×长×大"三元断奶仔猪，随机分为9个组，分别为对照组（Gln和IMO添加水平均为0 g/kg）、Ⅰ组（Gln和IMO添加水平分别为0、6 g/kg）、Ⅱ组（Gln和IMO添加水平分别为0、10 g/kg）、Ⅲ组（Gln和IMO添加水平分别为10、0 g/kg）、Ⅳ组（Gln和IMO添加水平分别为10、6 g/kg）、Ⅴ组（Gln和IMO添加水平分别为10、10 g/kg）、Ⅵ组（Gln和IMO添加水平分别为15、0 g/kg）、Ⅶ组（Gln和IMO添加水平分别为15、6 g/kg）和Ⅷ组（Gln和IMO添加水平分别为15、10 g/kg），每组3个重复，每个重复3头猪。预试期7 d，正试期21 d。结果表明：1）饲粮添加15 g/kg Gln显著提高断奶仔猪的血清免疫球蛋白M（IgM）含量（P<0.05），对血清免疫球蛋白A（IgA）和免疫球蛋白G（IgG）含量无显著影响（P>0.05）；饲粮添加IMO对血清IgA、IgG和IgM含量无显著影响（P>0.05）；Gln和IMO的互作效应对血清IgM含量有显著影响（P<0.05），尤以Ⅳ组和Ⅶ组效果较好。2）饲粮添加Gln显著降低断奶仔猪的血清丙二醛（MDA）含量（P<0.05），对血清超氧化物歧化酶（SOD）活性及总抗氧化能力（T-AOC）无显著影响（P>0.05）；与对照组相比，饲粮添加6 g/kg IMO显著降低血清MDA含量（P<0.05），对血清SOD活性及T-AOC无显著影响（P>0.05）；Gln和IMO的互作效应对血清MDA含量有显著影响（P<0.05），对血清SOD活性有提高趋势；综合来看，尤以Ⅷ组效果最好。以上结果提示，饲粮添加15 g/kg Gln和6 g/kg IMO可较好地改善断奶仔猪的免疫功能和抗氧化能力。

This research was performed to observe the effects of glutamine (Gln), Isomaltooligosaccharide (IMO) and their interaction on serum immune indexes and antioxidant capacity of weaned piglets. Eighty-one healthy "Duroc×Landrace×Yorkshire" crossbred piglets weaned at 28 days of age with similar body weight of (7.54±0.62) kg was randomly distributed into 9 groups with 3 replicates per group and 3 piglets per replicate by factorial design with two factors and three levels. Piglets were fed the diets supplemented with 0 g/kg both Gln and IMO (control group), 0 g/kg Gln and 6 g/kg IMO (groupⅠ), 0 g/kg Gln and 10 g/kg IMO (groupⅡ), 10 g/kg Gln and 0 g/kg IMO (group Ⅲ), 10 g/kg Gln and 6 g/kg IMO (group Ⅳ), 10 g/kg Gln and 10 g/kg IMO (group Ⅴ), 15 g/kg Gln and 0 g/kg IMO (group Ⅵ), 15 g/kg Gln and 6 g/kg IMO (group Ⅶ), 15 g/kg Gln and 10 g/kg IMO (group Ⅷ), respectively. The pretest lasted for 7 days, and the experiment lasted for 21 days. The results showed as follows:1) diets supplemented with 15 g/kg Gln significantly increased the content of immunoglobulin M (IgM) in serum of weaned piglets (P<0.05), and had no significant effects on the contents of immunoglobulin A (IgA) and immunoglobulin G (IgG) in serum (P>0.05). Diets supplemented with IMO had no significant effects on the contents of IgA, IgG and IgM in serum (P>0.05). The interaction of Gln and IMO had significant effect on the content of IgM in serum (P<0.05), especially in groups Ⅳ and Ⅶ. 2) Diets supplemented with Gln significantly decreased the content of malondialdehyde (MDA) in serum of weaned piglets (P<0.05), and had no significant effects on the activity of superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) in serum (P>0.05). Compared with the control group, diet supplemented with 6 g/kg IMO significantly decreased the content of MDA in serum (P<0.05), and had no significant effects on the activity of SOD and T-AOC in serum (P>0.05). The interaction of Gln and IMO had significant effect on the content of MDA in serum (P<0.05), and had an increasing tendency for the activity of SOD in serum. Taken together, the effect of group Ⅷ was the best. It is concluded that diets supplement with 15 g/kg Gln and 6 g/kg IMO can improve immune function and antioxidant capacity of weaned piglets.