综述 Review

壳聚糖的生物学功能及其在畜禽生产中的应用

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  • 1. 湖南农业大学动物科学技术学院, 长沙 410128;
    2. 湖南畜禽安全生产协同创新中心, 长沙 410128
杨玲(1995-),女,湖南衡山人,硕士研究生,研究方向为动物营养与饲料科学。E-mail:763707648@qq.com

收稿日期: 2018-08-22

  网络出版日期: 2019-03-18

基金资助

国家自然科学基金项目(31872991)

Biological Function of Chitosan and Its Application in Livestock and Poultry Production

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  • 1. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
    2. Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China

Received date: 2018-08-22

  Online published: 2019-03-18

摘要

壳聚糖(chitosan)是甲壳素脱乙酰基后的产物,是天然多糖中唯一的碱性多糖,其自然资源丰富、安全无毒、不产生耐药性、生产成本低,具有改善动物生长性能、增强机体免疫力、调节脂肪代谢、抗菌抑菌和抗氧化等多种生物学功能,被认为是具有广泛开发前景的绿色添加剂。本文就壳聚糖生物学特性、生理功能及其在畜禽生产中的应用现状进行综述,以期为其在畜禽生产中的应用提供参考依据。

本文引用格式

杨玲, 何荣香, 马玉静, 贺建华 . 壳聚糖的生物学功能及其在畜禽生产中的应用[J]. 动物营养学报, 2019 , 31(3) : 1037 -1043 . DOI: 10.3969/j.issn.1006-267x.2019.03.008

Abstract

Chitosan is an active product converted from chitin by deacetylation, which is the only alkaline polysaccharide in natural polysaccharidea. It is a kind of rich natural resource, characterized by safety, no residue, non-drug resistance and low cost of production. Chitosan has many biological functions such as improving animal growth performance, enhancing the immunity, regulating fat metabolism, bacteria resistance and bacteriostasis and improving the antioxidant capacity which is considered as a kind of green additive with broad development prospects in livestock and poultry production. This article reviewed the biological characteristics, physiological functions and application of chitosan in livestock and poultry production so as to provide the reference for its scientific application in livestock and poultry production.

参考文献

[1] 梁慧培,覃小丽,钟金锋.壳寡糖制备和生理活性的研究进展[J].食品工业科技,2016,37(3):384-388.

[2] YANG C M,FERKET P R,HONG Q H,et al.Effect of chito-oligosaccharide on growth performance,intestinal barrier function,intestinal morphology and cecal microflora in weaned pigs[J].Journal of Animal Science,2012,90(8):2671-2676.

[3] ANANDAN R,GANESAN B,OBULESU T,et al.Dietary chitosan supplementation attenuates isoprenaline-induced oxidative stress in rat myocardium[J].International Journal of Biological Macromolecules,2012,51(5):783-787.

[4] 张丽萍,董万福.低聚壳聚糖在断奶仔猪应用的研究进展[J].饲料研究,2016(6):12-15.

[5] LIU S H,HE S P,CHIANG M T.Effects of long-term feeding of chitosan on postprandial lipid responses and lipid metabolism in a high-sucrose-diet-impaired glucose-tolerant rat model[J].Journal of Agricultural and Food Chemistry,2012,60(17):4306-4313.

[6] 张强,胡维岗,金新文.壳聚糖-蒲公英提取物的抑菌活性与稳定性研究[J].食品工业科技,2015,36(20):150-154.

[7] 袁悦,董双双,冯文佩,等.壳聚糖在鸡养殖中的作用研究进展[J].江西饲料,2016(5):17-20.

[8] AHMED S,IKRAM S.Chitosan & its derivatives:a review in recent innovations[J].International Journal of Pharmaceutical Sciences and Research,2015,6(1):14-30.

[9] WALCZAK K,THIELE J,GEISLER D,et al.Effect of chemical disinfection on chitosan coated PMMA and PETG surfaces-an in vitro study[J].Polymers,2018,10(5):536.

[10] KEREC M,BOGATAJ M,VERANIC P,et al.Permeability of pig urinary bladder wall:the effect of chitosan and the role of calcium[J].European Journal of Pharmaceutical Sciences,2005,25(1):113-121.

[11] JIN Q,YU H H,WANG X Q,et al.Effect of the molecular weight of water-soluble chitosan on its fat-/cholesterol-binding capacities and inhibitory activities to pancreatic lipase[J].PeerJ,2017,5(3):e3279.

[12] TRIVEDI V R,SATIA M C,DESCHAMPS A,et al.Single-blind,placebo controlled randomised clinical study of chitosan for body weight reduction[J].Nutrition Journal,2016,15:3.

[13] LIU J N,ZHANG J L,XIA W S.Hypocholesterolaemic effects of different chitosan samples in vitro and in vivo[J].Food Chemistry,2008,107(1):419-425.

[14] SUMIYOSHI M,KIMURA Y.Low molecular weight chitosan inhibits obesity induced by feeding a high-fat diet long-term in mice[J].Journal of Pharmacy and Pharmacology,2006,58(2):201-207.

[15] DIMZON I K D,EBERT J,KNEPPER T P.The interaction of chitosan and olive oil:effects of degree of deacetylation and degree of polymerization[J].Carbohydrate Polymers,2013,92(1):564-570.

[16] 孙铭维,童津津,张华,等.壳聚糖在奶牛中的生物学功能及应用[J].动物营养学报,2018,30(6):2079-2084.

[17] KONG M,CHEN X G,LIU C S,et al.Antibacterial mechanism of chitosan microspheres in a solid dispersing system against E. coli[J].Colloids and Surfaces B:Biointerfaces,2008,65(2):197-202.

[18] PERINELLI D R,FAGIOLI L,CAMPANA R,et al.Chitosan-based nanosystems and their exploited antimicrobial activity[J].European Journal of Pharmaceutical Sciences,2018,117:8-20.

[19] YANG G Y,JIN Q,XU C L,et al.Synthesis,characterization and antifungal activity of coumarin-functionalized chitosan derivatives[J].International Journal of Biological Macromolecules,2018,106:179-184.

[20] VERLEE A,MINCKE S,STEVENS C V.Recent developments in antibacterial and antifungal chitosan and its derivatives[J].Carbohydrate Polymers,2017,164:268-283.

[21] 李俊良.壳聚糖对断奶仔猪免疫功能的影响及其调节机制的研究[D].博士学位论文.呼和浩特:内蒙古农业大学,2014.

[22] MA Y F,HUANG Q C,LV M Y,et al.Chitosan-Zn Chelate increases antioxidant enzyme activity and improves immune function in weaned piglets[J].Biological Trace Element Research,2014,158(1):45-50.

[23] HUANG B,XIAO D F,TAN B,et al.Chitosan oligosaccharide reduces intestinal inflammation that involves calcium-sensing receptor (CaSR) activation in lipopolysaccharide (LPS)-challenged piglets[J].Journal of Agricultural and Food Chemistry,2016,64(1):245-252.

[24] TOMIDA H,FUJⅡ T,FURUTANI N,et al.Antioxidant properties of some different molecular weight chitosans[J].Carbohydrate Research,2009,344(13):1690-1696.

[25] 徐元庆,王哲奇,史彬林,等.壳聚糖对断奶仔猪生长性能、粪便评分及血清激素和T淋巴细胞亚群的影响[J].动物营养学报,2017,29(5):1678-1686.

[26] AHN C B,JUNG W K,PARK S J.Gallic ACID-g-Chitosan modulates inflammatory responses in LPS-Stimulated RAW264.7 cells via NF-κB,AP-1,and MAPK pathways[J].Inflammation,2016,39(1):366-374.

[27] AHN C B,JE J Y,KIM Y S,et al.Induction of Nrf2-mediated phase Ⅱ detoxifying/antioxidant enzymes in vitro by chitosan-caffeic acid against hydrogen peroxide-induced hepatotoxicity through JNK/ERK pathway[J].Molecular and Cellular Biochemistry,2017,424(1/2):79-86.

[28] 高晶晶,张凤洪,王立红,等.壳聚糖抗氧化效果的研究[J].兽医导刊,2017(23):69-71.

[29] HU S L,WANG Y,WEN X L,et al.Effects of low-molecular-weight chitosan on the growth performance,intestinal morphology,barrier function,cytokine expression and antioxidant system of weaned piglets[J].BMC Veterinary Research,2018,14:215.

[30] CHO Y S,LEE S H,KIM S K,et al.Aminoethyl-chitosan inhibits LPS-induced inflammatory mediators,iNOS and COX-2 expression in RAW264.7 mouse macrophages[J].Process Biochemistry,2011,46(2):465-470.

[31] 杨伟丽,胡琴,王春梅,等.低聚壳聚糖和合生元对生长育肥猪生产性能、血清指标及肌肉成分的影响[J].家畜生态学报,2016,37(4):27-31.

[32] 王玉,王丽,郑春田.壳聚糖在断奶仔猪生产上的应用及研究进展[J].中国畜牧杂志,2016,52(11):78-81.

[33] YUAN S B,CHEN H.Effects of dietary supplementation of chitosan on growth performance and immune index in ducks[J].African Journal of Biotechnology,2012,11(14):3490-3495.

[34] 赵悦,盛东峰,杨海明,等.壳聚糖对14~70日龄扬州鹅生长性能、屠宰性能、脏器指数及血清生化指标的影响[J].动物营养学报,2017,29(5):1618-1626.

[35] 刘莹莹,张星,任慧波,等.低聚壳聚糖对母猪繁殖性能、泌乳性能和血浆生化指标的影响[J].动物营养学报,2017,29(12):4525-4533.

[36] 苗志国,魏攀鹏,杨志刚,等.膨化壳聚糖微粒对育肥猪胴体组成与肉品质特性的影响[J].中国饲料,2018(15):54-57.

[37] MENG Q W,YAN L,AO X,et al.Effects of chito-oligosaccharide supplementation on egg production,nutrient digestibility,egg quality and blood profiles in laying hens[J].Asian-Australasian Journal of Animal Science,2010,23(11):1476-1481.

[38] PORTUGAL-ZEGARRA M C C,SANTOS A M P,SILVA A M A D,et al.Chitosan films incorporated with antioxidant extract of acerola agroindustrial residue applied in chicken thigh[J].Journal of Food Processing and Preservation,2018,42(4):e13578.

[39] 胡忠泽,岳益佳,邱玮.壳聚糖对淮南麻鸡肉质的影响[J].饲料研究,2013(12):57-59,79.

[40] 陈刚耀,唐志刚,温超.低聚壳聚糖对生长育肥猪抗氧化性能、脂类代谢和肌肉品质的影响[J].粮食与饲料工业,2012(8):54-57.

[41] OKAMOTO Y,KAWAKAMI K,MIYATAKE K,et al.Analgesic effects of chitin and chitosan[J].Carbohydrate Polymers,2002,49(3):249-252.

[42] CROISIER F,JÉRÔME C.Chitosan-based biomaterials for tissue engineering[J].European Polymer Journal,2013,49(4):780-792.

[43] TAMER T M,VALACHOVÁ K,HASSAN M A.Chitosan/hyaluronan/edaravone membranes for anti-inflammatory wound dressing:in vitro and in vivo evaluation studies[J].Materials Science and Engineering:C,2018,90:227-235.

[44] CHOU T C,FU E,WU C J,et al.Chitosan enhances platelet adhesion and aggregation[J].Biochemical and Biophysical Research Communications,2003,302(3):480-483.

[45] MANIVASAGAN P,BHARATHIRAJA S,MOORTHY M S,et al.Biocompatible chitosan oligosaccharide modified gold nanorods as highly effective photothermal agents for ablation of breast cancer cells[J].Polymers,2018,10(3):232.

[46] DEBNATH S K,SAISIVAM S,DEBANTH M,et al.Development and evaluation of chitosan nanoparticles based dry powder inhalation formulations of prothionamide[J].PLoS One,2018,13(1):e0190976.

[47] 李诗怡,杨靖亚,喻文娟,等.联合使用羧甲基壳聚糖与阿霉素抗肿瘤效应[J].食品工业科技,2018,39(5):110-112,118.

[48] ASLI A,BROUILLETTE E,STER C,et al.Antibiofilm and antibacterial effects of specific chitosan molecules on Staphylococcus Aureus isolates associated with bovine mastitis[J].PLoS One,2017,12(5):e0176988.

[49] 夏正东.纳米壳聚糖对大鼠脾脏功能的影响[J].滨州医学院学报,2017,40(6):405-406,438.
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