综述 Review

黄烷醇对动物胰岛素抵抗状态下血糖稳态的调控作用及其机理

  • 张珍誉 ,
  • 赵华 ,
  • 陈小玲 ,
  • 贾刚
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  • 1. 四川农业大学动物营养研究所, 成都 611130;
    2. 眉山职业技术学院, 眉山 620010
张珍誉(1984-),女,湖南沅江人,博士研究生,研究方向为饲料资源开发与高效利用。E-mail:zhangzheny1111@126.com

收稿日期: 2019-01-08

  网络出版日期: 2019-08-19

基金资助

“十三五”国家重点研发项目(2017YFD0502000)

Regulation of Flavanols on Blood Glucose Homeostasis in Insulin Resistant Animal and Its Mechanisms

  • ZHANG Zhenyu ,
  • ZHAO Hua ,
  • CHEN Xiaoling ,
  • JIA Gang
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  • 1. Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China;
    2. Meishan Vocational Technical College, Meishan 620010, China

Received date: 2019-01-08

  Online published: 2019-08-19

摘要

血糖稳态对动物机体各项生理功能的正常发挥起着重要作用。黄烷醇是一类来源于植物的生物类黄酮物质,研究表明,黄烷醇可以平衡动物胰岛素抵抗状态下的血糖稳态,其机制可能涉及调节肠道碳水化合物的消化吸收效率、增加胰高血糖素样肽-1的活性、促进胰岛β细胞分泌胰岛素、提升肝糖原合成效率以及降低机体炎症来保护胰岛素信号转导途径不被破坏等方面。本文将黄烷醇对动物胰岛素抵抗状态下血糖稳态的调控作用及其机理作一概述,为其在生产和临床上的应用提供依据。

本文引用格式

张珍誉 , 赵华 , 陈小玲 , 贾刚 . 黄烷醇对动物胰岛素抵抗状态下血糖稳态的调控作用及其机理[J]. 动物营养学报, 2019 , 31(8) : 3431 -3437 . DOI: 10.3969/j.issn.1006-267x.2019.08.001

Abstract

Blood glucose homeostasis plays an important role in various physiological functions of animals. Flavanols is a kind of bioflavonoids derived from plants. Studies have proved that flavanols can maintain blood glucose homeostasis in insulin resistant animals. The mechanisms may involve regulating digestion and absorption efficiency of intestinal carbohydrates, increasing the activity of glucagon like peptide-1, promoting insulin secretion in islet beta cells, enhancing the efficiency of liver glycogen synthesis and decreasing inflammatory reaction to protect insulin signal transduction pathway from disruption. This paper briefly reviewed the regulation of flavanols on blood glucose homeostasis in insulin resistant animal and its mechanisms, and aimed to provide a basis for its application in animal husbandry and clinical treatment.

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