综述 Review

胆汁酸的肠肝循环及胆汁酸受体在糖脂代谢中的调控作用

  • 苏冠宁 ,
  • 孙赫 ,
  • 吴高峰 ,
  • 胡建民
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  • 1. 沈阳农业大学畜牧兽医学院, 沈阳 110866;
    2. 华中农业大学动物医学院, 武汉 430070
苏冠宁(1995-),男,辽宁营口人,硕士研究生,研究方向为动物生理学。E-mail:1245600009@qq.com

收稿日期: 2019-01-08

  网络出版日期: 2019-08-19

基金资助

国家自然科学基金项目“基于线粒体稳态的牛磺酸对蛋鸡脂肪肝综合征预防作用研究”(31772694);国家自然科学基金项目“牛磺酸抑制高糖下α细胞胰高血糖素分泌及促进其向β细胞转化机制的研究”(31872441)

Enterohepatic Circulation of Bile Acids and Regulation Roles of Bile Acid Receptors in Glycolipid Metabolism

  • SU Guanning ,
  • SUN He ,
  • WU Gaofeng ,
  • HU Jianmin
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  • 1. Institute of Animal Husbandry and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China;
    2. College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China

Received date: 2019-01-08

  Online published: 2019-08-19

摘要

胆汁酸是胆汁的主要成分,在体内以多种形式存在。随着对胆汁酸研究的深入,学者们发现胆汁酸是体内的一种重要的信号分子,通过介导胆汁酸受体而发挥相应的生物学效应。肠肝循环是指胆汁酸合成、分泌、排泄、再吸收的循环过程。近年来研究发现胆汁酸与其受体结合后,可以调控胆汁酸的肠肝循环过程,进而调节糖脂代谢。本文针对胆汁酸的肠肝循环以及胆汁酸受体在糖脂代谢中的调控作用进行综述,以期为今后探究胆汁酸及其受体在代谢相关疾病防治中的作用提供有价值的参考。

本文引用格式

苏冠宁 , 孙赫 , 吴高峰 , 胡建民 . 胆汁酸的肠肝循环及胆汁酸受体在糖脂代谢中的调控作用[J]. 动物营养学报, 2019 , 31(8) : 3511 -3521 . DOI: 10.3969/j.issn.1006-267x.2019.08.011

Abstract

Bile acids exist in many forms in the body as the principal constituent of bile. With the in-depth study of bile acids, scholars have found that bile acids are an important signal molecule in the body, which mediate bile acid receptors and exert corresponding biological effects. Enterohepatic circulation refers to the process of bile acid synthesis, secretion, excretion and reabsorption. In recent years, studies have shown that bile acids can regulate the enterohepatic circulation after binding with their receptors, thereby regulating glycolipid metabolism. In this paper, the enterohepatic circulation of bile acids and the regulation role of bile acid receptors in glycolipid metabolism were reviewed, so as to provide valuable references for the future research on the role of bile acids and its receptors in the prevention and treatment of metabolic diseases.

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