[1] FLOHE L,GVNZLER W A,SCHOCK H H.Glutathione peroxidase:a selenoenzyme[J].FEBS Letters,1973,32(1):132-134.

[2] MANSOUR A T E,GODA A A,OMAR E A,et al.Dietary supplementation of organic selenium improves growth,survival,antioxidant and immune status of meagre,Argyrosomus regius,juveniles[J].Fish & Shellfish Immunology,2017,68:516-524.
[3] WALLACE L G,BOBE G,VORACHEK W R,et al.Effects of feeding pregnant beef cows selenium-enriched alfalfa hay on selenium status and antibody titers in their newborn calves[J].Journal of Animal Science,2017,95(6):2408-2420.

[4] 吴显实,张克春,卫程武,等.日粮添加富硒益生菌对奶牛硒吸收转化、抗氧化能力与生产性能的影响[J].中国兽医学报,2010,30(8):1111-1114,1132.
[5] 韩博,梁俭,张一贤,等.日粮添加硒碘铜对宁夏地区奶牛生产和繁殖性能的影响[J].南京农业大学学报,2000,23(3):76-80.
[6] SERRÃO V H B,SILVA I R,DE SILVA M T A,et al.The unique tRNA
Sec and its role in selenocysteine biosynthesis[J].Amino Acids,2018,50(9):1145-1167.

[7] SANTESMASSES D,MARIOTTI M,GUIGÍ R.Computational identification of the selenocysteine tRNA (tRNASec) in genomes[J].PLoS Computational Biology,2017,13(2):e1005383.
[8] OELZE M,KRÖLLER-SCHÖN S,STEVEN S,et al.Glutathione peroxidase-1 deficiency potentiates dysregulatory modifications of endothelial nitric oxide synthase and vascular dysfunction in aging[J].Hypertension,2014,63(2):390-396.

[9] YANT L J,RAN Q T,RAO L,et al.The selenoprotein GPx4 is essential for mouse development and protects from radiation and oxidative damage insults[J].Free Radical Biology and Medicine,2003,34(4):496-502.

[10] ESWORTHY R S,ARANDA R,MARTÍN M G,et al.Mice with combined disruption of GPx1 and GPx2 genes have colitis[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2001,281(3):G848-G855.
[11] OLSON G E,WHITIN J C,HILL K E,et al.Extracellular glutathione peroxidase (GPx3) binds specifically to basement membranes of mouse renal cortex tubule cells[J].American Journal of Physiology-Renal Physiology,2010,298(5):F1244-F1253.
[12] CAO J Y,DIXON S J.Mechanisms of ferroptosis[J].Cellular and Molecular Life Sciences,2016,73(11/12):2195-2209.
[13] INGOLD I,BERNDT C,SCHMITT S,et al.Selenium utilization by GPx4 is required to prevent hydroperoxide-induced ferroptosis[J].Cell,2018,172(3):409-422.

[14] ZHANG J M,ZHANG B X,LI X M,et al.Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents:an update[J].Medicinal Research Reviews,2019,39(1):5-39.

[15] WHAYNE T F,Jr.,PARINANDI N,MAULIK N.Thioredoxins in cardiovascular disease[J].Canadian Journal of Physiology and Pharmacology,2015,93(11):903-911.

[16] SCALCON V,BINDOLI A,RIGOBELLO M P.Significance of the mitochondrial thioredoxin reductase in cancer cells:an update on role,targets and inhibitors[J].Free Radical Biology and Medicine,2018,127:62-79.
[17] WAKASUGI N,TAGAYA Y,WAKASUGI H,et al.Adult T-cell leukemia-derived factor/thioredoxin,produced by both human T-lymphotropic virus type Ⅰ-and Epstein-Barr virus-transformed lymphocytes,acts as an autocrine growth factor and synergizes with interleukin 1 and interleukin 2[J].Proceedings of the National Academy of Sciences of the United States of America,1990,87(21):8282-8286.

[18] MOUGIAKAKOS D,JOHANSSON C C,JITSCHIN R,et al.Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress[J].Blood,2011,117(3):857-861.

[19] TAN S X,GREETHAM D,RAETH S,et al.The thioredoxin-thioredoxin reductase system can function in vivo as an alternative system to reduce oxidized glutathione in Saccharomyces cerevisiae[J].Journal of Biological Chemistry,2010,285(9):6118-6126.

[20] THOMAS S R,MCTAMNEY P M,ADLER J M,et al.Crystal structure of iodotyrosine deiodinase,a novel flavoprotein responsible for iodide salvage in thyroid glands[J].Journal of Biological Chemistry,2009,284(29):19659-19667.

[21] 孙东波,张健,丁岚峰,等.缺硒对鸡甲状腺功能的影响[J].黑龙江畜牧兽医,2010(15):108-110.
[22] HILL K E,ZHOU J D,MCMAHAN W J,et al.Deletion of selenoprotein P alters distribution of selenium in the mouse[J].Journal of Biological Chemistry,2003,278(16):13640-13646.

[23] LIU Y,ZHANG W,ZHAO J T,et al.Selenoprotein P as the major transporter for mercury in serum from methylmercury-poisoned rats[J].Journal of Trace Elements in Medicine and Biology,2018,50:589-595.
[24] ROMAN M,JITARU P,BARBANTE C.Selenium biochemistry and its role for human health[J].Metallomics,2014,6(1):25-54.

[25] SHCHEDRINA V A,ZHANG Y,LABUNSKYY V M,et al.Structure-function relations,physiological roles,and evolution of mammalian ER-resident selenoproteins[J].Antioxidants & Redox Signaling,2010,12(7):839-849.

[26] HAN S J,LEE B C,YIM S H,et al.Characterization of mammalian selenoprotein O:a redox-active mitochondrial protein[J].PLoS One,2014,9(4):e95518.
[27] LU C L,QIU F C,ZHOU H J,et al.Identification and characterization of selenoprotein K:an antioxidant in cardiomyocytes[J].FEBS Letters,2006,580(22):5189-5197.

[28] CHEN X D,ZHAO Z P,ZHOU J C,et al.Evolution,regulation,and function of porcine selenogenome[J].Free Radical Biology and Medicine,2018,127:116-123.
[29] XU S Z,LEE S H,LILLEHOJ H S,et al.Dietary sodium selenite affects host intestinal and systemic immune response and disease susceptibility to necrotic enteritis in commercial broilers[J].British Poultry Science,2015,56(1):103-112.

[30] SUN L H,PI D A,ZHAO L,et al.Response of selenium and selenogenome in immune tissues to LPS-induced inflammatory reactions in pigs[J].Biological Trace Element Research,2017,177(1):90-96.

[31] SONG K D,DOWD S E,LEE H K,et al.Long-term dietary supplementation of organic selenium modulates gene expression profiles in leukocytes of adult pigs[J].Animal Science Journal,2013,84(3):238-246.

[32] ZHAO Y,LI H,MEN L L,et al.Effects of selenoprotein S on oxidative injury in human endothelial cells[J].Journal of Translational Medicine,2013,11:287.
[33] ARIBI M,MEZIANE W,HABI S,et al.Macrophage bactericidal activities against Staphylococcus aureus are enhanced in vivo by selenium supplementation in a dose-dependent manner[J].PLoS One,2015,10(9):e0135515.
[34] LIAO C,HARDISON R C,KENNETT M J,et al.Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis[J].Blood,2018,131(23):2568-2580.

[35] LIAO C,CARLSON B A,PAULSON R F,et al.The intricate role of selenium and selenoproteins in erythropoiesis[J].Free Radical Biology and Medicine,2018,127:165-171.
[36] 邹悦,梁峰,周烁,等.低硒对鸡红细胞抗氧化功能与免疫功能影响的研究[J].黑龙江畜牧兽医,2017(5):171-175.
[37] 鲁敏,冉林武,叶耿坪,等.日粮添加富硒益生菌对山羊血液学指标和抗氧化能力的影响[J].畜牧与兽医,2013,45(12):94-97.
[38] AMARA I B,HAKIM A,TROUDI A.Protective effects of selenium on methimazole-induced anemia and oxidative stress in adult rats and their offspring[J].Human & Experimental Toxicology,2011,30(10):1549-1560.

[39] KAWATANI Y,SUZUKI T,SHIMIZU R,et al.Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia[J].Blood,2011,117(3):986-996.

[40] HAWKES W C,RICHTER D,ALKAN Z.Dietary selenium supplementation and whole blood gene expression in healthy North American men[J].Biological Trace Element Research,2013,155(2):201-208.

[41] TANAKA A,KATO A,SUZUKI Y,et al.Association of increased indoleamine 2,3-dioxygenase with impaired natural killer cell activity in hemodialysis patients[J].Therapeutic Apheresis and Dialysis,2014,18(1):19-23.

[42] SUN Z P,LIU C,PAN T R,et al.Selenium accelerates chicken dendritic cells differentiation and affects selenoproteins expression[J].Developmental & Comparative Immunology,2017,77:30-37.
[43] LIU Y,ZHAO H,ZHANG Q S,et al.Prolonged dietary selenium deficiency or excess does not globally affect selenoprotein gene expression and/or protein production in various tissues of pigs[J].The Journal of Nutrition,2012,142(8):1410-1416.

[44] JIN X,XU Z,ZHAO X,et al.The antagonistic effect of selenium on lead-induced apoptosis via mitochondrial dynamics pathway in the chicken kidney[J].Chemosphere,2017,180:259-266.
[45] YANG T S,CAO C Y,YANG J,et al.miR-200a-5p regulates myocardial necroptosis induced by Se deficiency via targeting RNF11[J].Redox Biology,2018,15:159-169.
[46] HUANG Z,ROSE A H,HOFFMANN P R.The role of selenium in inflammation and immunity:from molecular mechanisms to therapeutic opportunities[J].Antioxidants & Redox Signaling,2012,16(7):705-743.

[47] SENA L A,LI S,JAIRAMAN A,et al.Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling[J].Immunity,2013,38(2):225-236.

[48] MAK T W,GRUSDAT M,DUNCAN G S,et al.Glutathione primes T cell metabolism for inflammation[J].Immunity,2017,46(4):675-689.

[49] JACKSON S H,DEVADAS S,KWON J,et al.T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation[J].Nature Immunology,2004,5(8):818-827.

[50] HOFFMANN F W,HASHIMOTO A C,SHAFER L A,et al.Dietary selenium modulates activation and differentiation of CD4
+ T cells in mice through a mechanism involving cellular free thiols[J].The Journal of Nutrition,2010,140(6):1155-1161.

[51] FALK M,BERNHOFT A,FRAMSTAD T,et al.Effects of dietary sodium selenite and organic selenium sources on immune and inflammatory responses and selenium deposition in growing pigs[J].Journal of Trace Elements in Medicine and Biology,2018,50:527-536.
[52] KHOSO P A,ZHANG Y M,YIN H,et al.Selenium deficiency affects immune function by influencing selenoprotein and cytokine expression in chicken spleen[J].Biological Trace Element Research,2019,187(2):506-516.

[53] LEE B C,LEE S G,CHOO M K,et al.Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo[J].Scientific Reports,2017,7:5119.
[54] BI C L,WANG H,WANG Y J,et al.Selenium inhibits Staphylococcus aureus-induced inflammation by suppressing the activation of the NF-κB and MAPK signalling pathways in RAW264.7 macrophages[J].European Journal of Pharmacology,2016,780:159-165.
[55] WHEELER M L,DEFRANCO A L.Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation[J].The Journal of Immunology,2012,189(9):4405-4416.

[56] OGURA M,INOUE T,YAMAKI J,et al.Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells in mice[J].European Journal of Immunology,2017,47(2):406-418.

[57] WERZ O,SZELLAS D,STEINHILBER D.Reactive oxygen species released from granulocytes stimulate 5-lipoxygenase activity in a B-lymphocytic cell line[J].European Journal of Biochemistry,2000,267(5):1263-1269.

[58] DALIA A M,LOH T C,SAZILI A Q,et al.Effects of vitamin E,inorganic selenium,bacterial organic selenium,and their combinations on immunity response in broiler chickens[J].BMC Veterinary Research,2018,14:249.
[59] CHEN J,ZHANG F T,GUAN W T,et al.Increasing selenium supply for heat-stressed or actively cooled sows improves piglet preweaning survival,colostrum and milk composition,as well as maternal selenium,antioxidant status and immunoglobulin transfer[J].Journal of Trace Elements in Medicine and Biology,2019,52:89-99.
[60] GELDERMAN A,CLAPPER J.Effects of inorganic or organic selenium on immunoglobulins in swine[J].Journal of Animal Science and Biotechnology,2013,4:47.
[61] CAO N,LI W Y,LI B X,et al.Transcriptome profiling reveals the immune response of goose T cells under selenium stimuli[J].Animal Science Journal,2017,88(12):2001-2009.

[62] POLIMENI M,GAZZANO E.Is redox signaling a feasible target for overcoming multidrug resistance in cancer chemotherapy?[J].Frontiers in Pharmacology,2014,5:286.
[63] BLOT W J,LI J Y,TAYLOR P R,et al.Nutrition intervention trials in Linxian,China:supplementation with specific vitamin/mineral combinations,cancer incidence,and disease-specific mortality in the general population[J].Journal of the National Cancer Institute,1993,85(18):1483-1491.

[64] MARK S D,QIAO Y L,DAWSEY S M,et al.Prospective study of serum selenium levels and incident esophageal and gastric cancers[J].Journal of the National Cancer Institute,2000,92(21):1753-1763.

[65] VINCETI M,FILIPPINI T,GIOVANE C D.Selenium for preventing cancer[J].Cochrane Database of Systematic Reviews,2018,1:CD005195.
[66] MISRA S,BOYLAN M,SELVAM A,et al.Redox-active selenium compounds-from toxicity and cell death to cancer treatment[J].Nutrients,2015,7(5):3536-3556.

[67] BRIGELIUS-FLOHÉ R,FLOHÉ L.Selenium and redox signaling[J].Archives of Biochemistry and Biophysics,2017,617:48-59.