综述 Review

黄连素的生物学功能及其在动物生产中的应用

  • 郭思杰 ,
  • 文伟 ,
  • 杨昆 ,
  • 孙志良
展开
  • 1. 湖南农业大学动物医学院, 长沙 410128;
    2. 湖南省兽药工程技术中心, 长沙 410128;
    3. 湖南农业大学动物科学技术学院, 长沙 410128
郭思杰(1995-),女,湖北天门人,硕士研究生,从事兽药创制与临床应用方向的研究。E-mail:1127929535@qq.com

收稿日期: 2019-03-26

  网络出版日期: 2019-10-17

基金资助

国家重点研发计划(2017YFD0501403)

Biological Function of Berberine and Its Application in Animal Production

  • GUO Sijie ,
  • WEN Wei ,
  • YANG Kun ,
  • SUN Zhiliang
Expand
  • 1. College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China;
    2. Hunan Province Veterinary Drug Engineering Technology Center, Changsha 410128, China;
    3. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China

Received date: 2019-03-26

  Online published: 2019-10-17

摘要

黄连素是从草本植物中提取的主要有效化学成分,具有抗菌、抗炎、抗氧化以及调节脂质代谢等生物学功能,其作为天然饲料添加剂的一种,在提高动物生产性能、调节肠道菌群平衡以及改善产品肉品质等方面效果显著,因而在畜禽生产中拥有广阔的应用前景。本文就黄连素的理化性质、提取工艺、生物学功能及其在畜禽生产中的应用展开综述,以期为黄连素在动物生产应用中提供参考依据。

本文引用格式

郭思杰 , 文伟 , 杨昆 , 孙志良 . 黄连素的生物学功能及其在动物生产中的应用[J]. 动物营养学报, 2019 , 31(10) : 4464 -4472 . DOI: 10.3969/j.issn.1006-267x.2019.10.008

Abstract

Berberine is a main effective chemical component extracted from herbaceous plants. It has biological functions such as antibacterial, anti-inflammatory, anti-oxidant and lipid metabolism regulation. It is a natural feed additive that improves animal performance and regulates intestinal tract. The effect of flora balance and improvement of meat quality of the product is remarkable, so it has broad application prospects in livestock production. This paper reviews the physicochemical properties, extraction process, biological functions of berberine and its application in livestock and poultry production, in order to provide reference for berberine in animal production applications.

参考文献

[1] ANDOLA H C,GAIRA K S,PANDEY A,et al.Influence of habitat characteristics and altitude on berberine content in Berberis jaeschkeana C.K. Schneid[J].Proceedings of the National Academy of Sciences,India Section B:Biological Sciences,2018,doi:10.1007/s40011-018-1014-9.
[2] HSU Y Y,CHEN C S,WU S N,et al.Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells[J].European Journal of Pharmaceutical Sciences,2012,46(5):415-425.  
[3] ZHANG Y L,LIANG Y E,HE C W.Anticancer activities and mechanisms of heat-clearing and detoxicating traditional Chinese herbal medicine[J].Chinese Medicine,2017,12:20.
[4] 张一波.黄连素降血糖及防治糖尿病慢性并发症的作用和机制[J].中国中医药信息杂志,2003,10(1):83-85.
[5] 杨菁,林菁.黄连素临床应用的研究[J].医学综述,2008,14(2):297-299.
[6] 王雨来,杨林,卢振,等.黄连素新剂型的研究进展[J].时珍国医药,2016,27(4):942-944.
[7] 中华人民共和国卫生部药典委员会.中华人民共和国药典(一部)[M].广州:广东科技出版社,1995.
[8] MOHAMMADZADEH N,MEHRI S,HOSSEINZADEH H.Berberis vulgaris and its constituent berberine as antidotes and protective agents against natural or chemical toxicities[J].Iranian Journal of Basic Medical Sciences,2017,20(5):538-551.
[9] GRYCOVÁ L,DOSTÁL J,MAREK R.Quaternary protoberberine alkaloids[J].Phytochemistry,2007,68(2):150-175.  
[10] TENG H,CHOI Y H.Optimization of microwave-assisted extraction of bioactive alkaloid compounds from rhizoma coptidis (Coptis chinensis Franch.)[J].Food Science and Biotechnology,2013,22(5):1-8.
[11] GARCÍA A,ALRIOLS M G,WUKOVITS W,et al.Assessment of biorefinery process intensification by ultrasound technology[J].Clean Technologies and Environmental Policy,2014,16(7):1403-1410.  
[12] XU B L,LI P Y,ZHANG G J.Comparative pharmacokinetics of puerarin,daidzin,baicalin,glycyrrhizic acid,liquiritin,berberine,palmatine and jateorhizine by liquid chromatography-mass spectrometry after oral administration of Gegenqinlian decoction and active components alignment (ACA) to rats[J].Journal of Chromatography B,2015,988:33-44.
[13] SUN R B,YANG N,KONG B,et al.Orally administered berberine modulates hepatic lipid metabolism by altering microbial bile acid metabolism and the intestinal FXR signaling pathway[J].Molecular Pharmacology,2017,91(2):110-122.  
[14] LIEU T,JAYAWEERA G,BUNNETT N W.GPBA:a GPCR for bile acids and an emerging therapeutic target for disorders of digestion and sensation[J].British Journal of Pharmacology,2014,171(5):1156-1166.  
[15] ZHANG Y Q,KAST-WOELBERN H R,EDWARDS P A.Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation[J].Journal of Biological Chemistry,2003,278(1):104-110.  
[16] 陈压西,阮雄中.脂肪酸转运蛋白CD36与代谢性炎症[C]//第十二届全国脂质与脂蛋白学术会议论文汇编.杭州:中国生物化学与分子生物学会脂质与脂蛋白专业委员会,2014.
[17] 罗映,金磊,何琦,等.小檗碱对兔血脂代谢及维生素D受体和胰岛素诱导基因2基因表达的影响[J].中草药,2011,42(8):1566-1570.
[18] XIE W D,GU D Y,LI J N,et al.Effects and action mechanisms of berberine and Rhizoma coptidis on gut microbes and obesity in high-fat diet-fed C57BL/6J mice[J].PLoS One,2011,6(9):e24520.
[19] 莫朝晖.胰岛素诱导基因(Insig2)在调控脂肪细胞分化与脂肪合成中作用的研究[D].博士学位论文.长沙:中南大学,2007.
[20] 柴红燕,刘芳,周新.固醇调节元件结合蛋白的研究[J].生命的化学,2002,22(5):442-444.
[21] CICERO A,ERTEK S.Metabolic and cardiovascular effects of berberine:from preclinical evidences to clinical trial results[J].Clinical Lipidology,2009,4(5):553-563.  
[22] 李葱晓.盐酸小檗碱对肉仔鸡生长性能、胴体品质及脂质代谢的影响[D].硕士学位论文.郑州:河南农业大学,2008.
[23] HAAS M E,LEVENSON A E,SUN X,et al.前蛋白转化酶枯草杆菌蛋白酶kexin-9在肾病综合征相关性高胆固醇血症中的作用[J].刘莉译.中华高血压杂志,2016,24(7):607.
[24] XIAO H B,SUN Z L,ZHANG H B,et al.Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation[J].Pharmacological Reports,2012,64(4):889-895.  
[25] CHANG T Y,LI B L,CHANG C C Y,et al.Acyl-coenzyme A:cholesterol acyltransferases[J].American Journal of Physiology:Endocrinology and Metabolism,2009,297(1):E1-E9.
[26] WANG Y W,YI X,GHANAM K,et al.Berberine decreases cholesterol levels in rats through multiple mechanisms,including inhibition of cholesterol absorption[J].Metabolism,2014,63(9):1167-1177.  
[27] BHADRA K,KUMAR G S.Therapeutic potential of nucleic acid-binding isoquinoline alkaloids:binding aspects and implications for drug design[J].Medicinal Research Reviews,2011,31(6):821-862.  
[28] 李红枚,党万太,杨小红.小檗碱抗炎机制的研究进展[J].中国医药导报,2017,14(33):31-34.
[29] FAN X D,WANG J,HOU J C,et al.Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway[J].Journal of Translational Medicine,2015,13:92.
[30] CHEN J W,CAO J T,FANG L,et al.Berberine derivatives reduce atherosclerotic plaque size and vulnerability in apoE-/- mice[J].Journal of Translational Medicine,2014,12:326.
[31] 田喆,谢晓晶,孙书林,等.黄连素对重症急性胰腺炎大鼠炎症反应的影响[J].海南医学,2018,29(4):448-451.
[32] WANG Y X,LIU L,ZENG Q X,et al.Synthesis and identification of novel berberine derivatives as potent inhibitors against TNF-α-induced NF-κB activation[J].Molecules,2017,22(8):1257.
[33] 李宇馨,李瑞海.小檗碱抗炎活性研究[J].实用药物与临床,2013,16(1):43-44.
[34] 蒋激扬,刘发.小檗碱抗炎免疫作用机制的探讨[J].西北药学杂志,1997,12(增刊):59-60.
[35] CERNÁKOVÁ M,KOŠTÁLOVÁ D.Antimicrobial activity of berberine-a constituent of Mahonia aquifolium[J].Folia Microbiologica,2002,47(4):375-378.  
[36] AMIN A H,SUBBAIAH T V,ABBASI K M.Berberine sulfate:antimicrobial activity,bioassay,and mode of action[J].Canadian Journal of Microbiology,1969,15(9):1067-1076.  
[37] 孟甄,金建玲,刘玉庆,等.细菌耐药性的诱导与消除[J].中国药理学通报,2003,19(9):1047-1051.
[38] WANG Y,FENG R,SHOU J W,et al.WITHDRAWN:transforming berberine into its intestine absorbable form by gut microbiota[J].Asian Journal of Pharmaceutical Sciences,2015,doi:10.1016/j.ajps.2015.10.047.
[39] LI C L,HUANG P,WONG K,et al.Coptisine-induced inhibition of Helicobacter pylori:elucidation of specific mechanisms by probing urease active site and its maturation process[J].Journal of Enzyme Inhibition and Medicinal Chemistry,2018,33(1):1362-1375.  
[40] FOLLMER C.Ureases as a target for the treatment of gastric and urinary infections[J].Journal of Clinical Pathology,2010,63(5):424-430.  
[41] DA SILVA A R,DE ANDRADE NETO J B,DA SILVA C R,et al.Berberine antifungal activity in fluconazole-resistant pathogenic yeasts:action mechanism evaluated by flow cytometry and biofilm growth inhibition in Candida spp.[J].Antimicrobial Agents and Chemotherapy,2016,60(6):3551-3557.  
[42] BANG S,KWON H,HWANG H S,et al.9-O-butyl-13-(4-isopropylbenzyl)berberine,KR-72,is a potent antifungal agent that inhibits the growth of Cryptococcus neoformans by regulating gene expression[J].PLoS One,2014,9(10):e109863.
[43] DHAMGAYE S,DEVAUX F,VANDEPUTTE P,et al.Molecular mechanisms of action of herbal antifungal alkaloid berberine,in Candida albicans[J].PLoS One,2014,9(8):e104554.
[44] 郑洪艳.原小檗碱类生物碱作用差异的机理研究[D].硕士学位论文.天津:天津医科大学,2004.
[45] 林媛,司书毅,蒋建东.小檗碱的抗菌作用[J].药学学报,2018,53(2):163-168.
[46] WU L T,TSOU M F,HO C C,et al.Berberine inhibits arylamine N-acetyltransferase activity and gene expression in Salmonella typhi[J].Current Microbiology,2005,51(4):255-261.  
[47] SUN D,COURTNEY H S,BEACHEY E H.Berberine sulfate blocks adherence of Streptococcus pyogenes to epithelial cells,fibronectin,and hexadecane[J].Antimicrobial Agents and Chemotherapy,1988,32(9):1370-1374.  
[48] AHRENS F A,ZHU B L.Effects of epinephrine,clonidine,L-phenylephrine,and morphine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin in pig jejunum[J].Canadian Journal of Physiology and Pharmacology,1982,60(12):1680-1685.  
[49] 李梦.小檗碱的肠道菌群生物转化研究[D].硕士学位论文.上海:上海交通大学,2014.
[50] RAHAL A,KUMAR A,SINGH V,et al.Oxidative stress,prooxidants,and antioxidants:the interplay[J].BioMed Research International,2014,2014:761264.
[51] LI Z,GENG Y N,JIANG J D,et al.Antioxidant and anti-inflammatory activities of berberine in the treatment of diabetes mellitus[J].Evidence-Based Complementary and Alternative Medicine,2014,2014:289264.
[52] YOKOZAWA T,ISHIDA A,CHO E J,et al.Coptidis rhizoma:protective effects against peroxynitrite-induced oxidative damage and elucidation of its active components[J].Journal of Pharmacy and Pharmacology,2004,56(4):547-556.  
[53] SHIRWAIKAR A,SHIRWAIKAR A,RAJENDRAN K,et al.In vitro antioxidant studies on the benzyl tetra isoquinoline alkaloid berberine[J].Biological and Pharmaceutical Bulletin,2006,29(9):1906-1910.  
[54] MO C F,WANG L,ZHANG J,et al.The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice[J].Antioxidants & Redox Signaling,2014,20(4):574-588.  
[55] VOMHOF-DEKREY E E,PICKLO M J.The Nrf2-antioxidant response element pathway:a target for regulating energy metabolism[J].The Journal of Nutritional Biochemistry,2012,23(10):1201-1206.  
[56] HSU Y Y,TSENG Y T,LO Y C.Berberine,a natural antidiabetes drug,attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth[J].Toxicology and Applied Pharmacology,2013,272(3):787-796.  
[57] CHANG X X,YAN H M,FEI J,et al.Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats[J].Journal of Lipid Research,2010,51(9):2504-2515.  
[58] DONG H,ZHAO Y,ZHAO L,et al.The effects of berberine on blood lipids:a systemic review and meta-analysis of randomized controlled trials[J].Planta Medica,2013,79(6):437-446.  
[59] TABESHPOUR J,IMENSHAHIDI M,HOSSEINZADEH H.A review of the effects of Berberis vulgaris and its major component,berberine,in metabolic syndrome[J].Iranian Journal of Basic Medical Sciences,2017,20(5):557-568.
[60] TRIMARCO V,CIMMINO C S,SANTORO M,et al.Nutraceuticals for blood pressure control in patients with high-normal or grade 1 hypertension[J].High Blood Pressure & Cardiovascular Prevention,2012,19(3):117-122.
[61] ZHOU Z W,ZHENG H C,ZHAO L F,et al.Effect of berberine on acetylcholine-induced atrial fibrillation in rabbit[J].American Journal of Translational Research,2015,7(8):1450-1457.
[62] BAE J,LEE D,KIM Y K,et al.Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1[J].Molecules and Cells,2013,35(2):151-157.  
[63] PANG B,ZHAO L H,ZHOU Q,et al.Application of berberine on treating type 2 diabetes mellitus[J].International Journal of Endocrinology,2015,2015:905749.
[64] WANG T,WANG N,SONG H,et al.Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine[J].European Journal of Pharmaceutical Sciences,2011,44(1/2):127-135.
[65] PARRY A J,NARITA M.Old cells,new tricks:chromatin structure in senescence[J].Mammalian Genome,2016,27(7/8):320-331.
[66] WU J X,HE Z Q,GAO X,et al.Oxidized high-density lipoprotein impairs endothelial progenitor cells' function by activation of CD36-MAPK-TSP-1 pathways[J].Antioxidants & Redox Signaling,2015,22(4):308-324.  
[67] 孙镇平,周保华,王秋生,等.小檗碱促进肉鸡生长代谢的试验观察[J].中国兽医杂志,2009,45(1):69-71.
[68] 周保华.小檗碱改善肉鸡盲肠微生态、生长代谢及免疫力的研究[D].硕士学位论文.扬州:扬州大学,2006.
[69] 荣娜.小檗碱促进獭兔生长代谢、盲肠微生物活力及免疫性能的研究[D].硕士学位论文.扬州:.扬州大学,2007.
[70] ZHAO R Q,MUEHLBAUER E,DECUYPERE E,et al.Effect of genotype-nutrition interaction on growth and somatotropic gene expression in the chicken[J].General and Comparative Endocrinology,2004,136(1):2-11.  
[71] ZHAO R,MUEHLBAUER E,DECUYPERE E,et al.Effect of genotype-nutrition interaction on growth and somatotropic gene expression in the chicken[J].General and Comparative Endocrinology,2004,136(1):2-11.  
[72] 郭云霞,王树香,郝庆红,等.动物肠道微生态系统及益生菌的营养功能[J].饲料研究,2009(6):24-25.
[73] 戎鑫仁,贺娅莎,王彦.盐酸小檗碱对糖尿病大鼠肠道菌群结构的影响[J].中西医结合心脑血管病杂志,2016,14(11):1221-1223.
[74] 王蓉,徐宗凯,杨燕,等.双歧杆菌微生态制剂对2型糖尿病模型大鼠炎症反应相关因子和抗氧化体系的影响[J].现代预防医学,2014,41(6):1086-1088.
[75] 汪水平,王文娟,刘凯,等.盐酸小檗碱对肉兔屠宰性能及肉质的影响[J].中国畜牧杂志,2013,49(9):50-53.
文章导航

/